Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"ERBB2"”.
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The Role of Erbb2 in Ultraviolet-Induced Nonmelanoma Skin Carcinogenesis
… UV, which has many effects on the skin. The RTK Erbb2 is activated by UV and is overexpressed in some skin cancer. Targeted Erbb2 overexpression in a mouse model leads to spontaneous skin tumor development [82, 86, 87], However, the role of Erbb2 in the UV response of the skin and during …
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Proteins Involved in HDACi Induced Decay of ERBB2 Transcripts in Breast Cancer
<p>ERBB2-positive breast cancer is an aggressive disease form that can result in rapid tumor growth and metastasis driven by the overexpression of ERBB2 growth factor receptors present on the cell surface. Currently, approved agents can target and disable ERBB2 receptor function, but as few as 30% …
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Charakterisierung von Schlüsselproteinen der Signaltransduktion (EGF-R, c-erbB2, Hsp90) in humanen Tumorxenografts mittels Gewebemikroarray
… der Signaltransduktion (EGF-R, c-erbB2, Hsp90) wurden in dieser Arbeit untersucht. Überexpression dieser Proteine in Tumoren geht mit schlechter Prognose für die Patienten einher. EGF-R und c-erbB2 sind deshalb interessante Targets für neue molekulare Tumortherapien. Spezifische …
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Nachweis von EGFR und ErbB2 Genamplifikationen in humanen Tumormodellen mittels Fluoreszenz-in-situ-Hybridisierung auf Gewebe- und Zelllinien-Mikroarrays
Die Tyrosin-Kinase-Rezeptoren EGFR und ErbB2 sind Proto-Onkogene, die durch Genamplifikation oder Überexpression der Genprodukte aktiviert werden können. In der vorliegenden Arbeit wurden ca. 150 Xenografts und 30 Zellinien der Freiburger Xenograft Sammlung mittels …
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Anti-Insulin Resistance Treatments Suppress Her2+ Breast Cancer Growth Via Altering Metabolism
… (<em>Lepr </em><sup>db/+</sup>) and MMTV-ErbB2 (<em>neu</em>) mice. The MMTV-ErbB2/<em>Lepr </em><sup>db/db</sup> mice had a poor survival rate compared with MMTV-ErbB2/<em>Lepr </em><sup>+/+ </sup>mice, and the log rank test of the Kaplan-Meier analysis showed that they were significantly …
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Merlin Regulation of Mouse Spinal Cord Neural Precursor Cell Function
… that Nf2-deficient NPCs exhibit high levels of ErbB2 activation. We further show that pharmacologic or shRNAi inhibition of ErbB2 restores Nf2-deficient NPC growth and glial differentiation to WT levels, and that NF2-associated spinal cord ependymomas exhibit increased ErbB2 activation. These …
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Role of CDC25 Phosphatases in Non-Melanoma Skin Cancer
… prognosis. In this research, the hypothesis that Erbb2 up-regulation of CDC25 phosphatases increases cell proliferation and contributes to skin cancer development was evaluated. CDC25A and CDC25C, but not CDC25B, expression were increased in the cytoplasm of both human and UV-induced mouse skin …
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Deciphering the Functions of Ets2, Pten and p53 in Stromal Fibroblasts in Multiple Breast Cancer Models
… of Ets2 in fibroblasts in both PyMT and ErbB2 driven tumorigenesis slowed the progression of these tumors without significantly effecting the development of the normal mammary gland. Gene expression profiling revealed Ets2 controls a tumor specific transcription program in fibroblasts …
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The application of genomic technologies to cancer and companion diagnostics.
… enters the clinic. In chapter 3 I discuss how ERBB2 amplification testing for breast cancer is currently dominated by immunohistochemistry (a single-gene test); and present the development, by the author, of a semi-quantitative PCR test for ERBB2 amplification. I also show that estimating ERBB2 …
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Spatial Stochastic Modeling of the ErbB Receptor Family
… trajectories. In the final study, we move on to erbB2 and erbB3 interactions. ErbB3, which is traditionally believed to be kinase dead, has recently been shown to have weak kinase activity. Through kinase assay experiments, we show in the presence of erbB2 and heregulin, erbB3 has measurable …
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Role of X-Linked Inhibitor of Apoptosis Protein in Therapeutic Resistance of Inflammatory Breast Cancer Cells
… of breast cancer that is often characterized by ErbB2 overexpression and ErbB2 activation. ErbB-targeting is clinically relevant using trastuzumab (anti-ErbB2 antibody) and lapatinib (small molecule ErbB1/2 inhibitor). However, acquired resistance is a common outcome even in IBC patients who show …
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In vitro and in vivo approaches to tumor targeting by phage display
… cancers are linked with the over-expression of ErbB2. Because of its critical role in signal transduction, the progression of breast cancer and its localization on the surface of several types of cancer cells, ErbB2 is a commonly used as a target for the search for protein and peptide ligands …
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Understanding Acquired Resistance to Lapatinib In Breast Cancer Cells
… breast carcinomas. Lapatinib is an ErbB1 and ErbB2 tyrosine kinase inhibitor that has been shown to have anti-proliferative effects in breast and lung cancer cells. Cells treated with Lapatinib undergo G1 phase arrest, followed by apoptosis. Lapatinib has been approved for clinical use, though …
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Targeting The Dimerization Of ERBB Receptor Tyrosine Kinases
… of EGF receptors with the related ErbB2 receptor. Three sub-projects were completed in the process. The first project explored the feasibility of inhibiting the EGF receptor by targeting receptor dimerization with small molecules. Two lead compounds were initially predicted by …
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Roles of Cytoplasmic Deacetylase Hdac6 in Oncogenic Tumorigenesis
… are more resistant to both oncogenic Ras and ErbB2-dependent transformation, indicating a critical role for HDAC6 in oncogene-induced transformation. Supporting this hypothesis, inactivation of HDAC6 in several human cancer cell lines effectively impairs anchorage-independent growth <em>in …
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ROLE OF THE ENDOCYTIC PROTEIN EPSIN 3 IN MAMMARY GLAND TRANSFORMATION
… Interestingly, the well-characterized oncogene ERBB2 is co-amplified with EPN3 in half of the EPN3-amplified cases, suggesting the possible cooperation of the two genes. By overexpressing EPN3 in non-transformed mammary epithelial cells (MCF10A), we showed that it induces a partial …
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Identification of Subclass-Specific Biomarkers by Developing an Integrated Database of Breast Cancer
… of breast cancer. For example, we selected ERBB2 status, which is one of the important markers in breast cancer, and “stage” information that classifies the cancer phase clinically. A Fisher’s p-value combined method is used for meta-analysis. Consequently we identified 52 and 54 …
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Measuring Single Cell Responses to Lapatinib In A Heterogeneous Population
… of the major targets in cancer has been the EGFR/ErbB2 network in breast and other cancer types. Prior work from our lab and others have shown alterations in the cellular network whereby compensatory upregulation of alternative pathways such as glucose uptake and metabolism can lead to acquired …
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Targeting Stromal-Mediated Resistance Mechanisms in Oncogenic KRAS-Driven Pancreatic Ductal Adenocarcinoma
… Neuregulin 1 (NRG1) activates upregulated ERBB2/3 receptors on cancer cells following KRAS inhibition, establishing a critical resistance pathway. Second, optimize tissue dissociation methodology was proposed for PDAC specimens, overcoming barriers created by the dense desmoplastic stroma …
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