Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"ERBB signaling"”.
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Investigations into the role of protein phosphatases in the EGFR signaling network
… the phosphorylation state of intracellular signaling molecules in conjunction with protein kinases. In order to better understand the role of phosphatases in the ErbB signaling network, experimental studies were carried out to validate assays and phosphatase inhibitors for gathering dynamic, …
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Role of Cuzd1 in mammary gland development and tumorigenesis
… epigen and epiregulin, which act via the ERBB receptors on the mammary epithelial cells. Interestingly, exposure of these cells to the EGF-like growth factors stimulated CUZD1 expression, triggered its nuclear translocation, and promoted CUZD1-dependent mitogenic activity. We postulated …
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Understanding Acquired Resistance to Lapatinib In Breast Cancer Cells
Signaling through epidermal growth factor receptor (EGFR/ErbB) family members plays a very important role in regulating proliferation, development, and malignant transformation of mammary epithelial cells. ErbB family members are often over-expressed in human breast carcinomas. Lapatinib is an …
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Effects of somatic cell nuclear transfer on transcripts related to IGF signaling, EGF signaling and cell adhesion during the peri-implantation period in cattle
… that insulin-like growth factor (IGF) signaling, epidermal growth factor (EGF) signaling, and cell adhesion are perturbed in bovine SCNT pregnancies during the peri-implantation period. To test this hypothesis, we analyzed transcriptomes of endometrial tissue and extra-embryonic tissue …
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Parameter and topology uncertainty for optimal experimental design
… experiment. We applied the method to a model of ErbB signaling. Finally, we developed a method for reducing the size of models defined as rule-based models. Unlike existing methods, this method handles compartments of models and allows for cycles between monomers. The methods developed here …
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Characterization of Erbb4 Expression In Osteosarcoma
<p>ERBB4 (Her-4) is a member of the ERBB family of Class I receptor tyrosine kinases. ERBB4 is unique within the ERBB family for alternate splicing in its juxtamembrane and cytoplasmic regions, which produces four juxtamembrane isoforms and two cytoplasmic isoforms. The cleavable juxtamembrane …