Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"ER-negative"”.
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Effects of Oestrogen Receptor Status of Women with Breast Cancer Treated with Tamoxifen at University Teaching Hospital and Cancer Diseases Hospital
The main objective of this study was to determine the prevalence of oestrogen receptor-negative breast cancers at UTH and CDH and its impact on tamoxifen management. The specific objectives of the study were to determine the prevalence of oestrogen receptor negative of breast cancer patients; to …
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Effects of Oestrogen Receptor Status of Women with Breast Cancer Treated with Tamoxifen at University Teaching Hospital and Cancer Diseases Hospital
The main objective of this study was to determine the prevalence of oestrogen receptor-negative breast cancers at UTH and CDH and its impact on tamoxifen management. The specific objectives of the study were to determine the prevalence of oestrogen receptor negative of breast cancer patients; to …
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Investigating The Effects of Silencing Epha2 In Metastatic Breast Cancer Cells
… receptor tyrosine kinase that is commonly over-expressed in cancers such as those of the prostate, colon, lung, and breast. For breast cancers, EphA2 overexpression is most prominent in the ER-negative subtype, and is associated with a higher rate of lung metastasis. Studies conducted to …
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The Development of the Prognostic Breast Cancer Model PREDICT
… for patients with early invasive breast cancer. Since its development in 2010, the model has shown a variety of prognostic outcomes among numerous studies. Due to improvements in breast cancer survival and advancements in cancer treatments, the model might be outdated and could lead to …
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Cytochrome P450 mRNA profile in human breast cancer cell lines.
… P450 enzymes (P450s) are involved in cancer development and treatment due to their roles in the oxidative metabolism of various compounds, both endogenous (e.g. oestrogen) and exogenous (e.g. tamoxifen). Intermediate P450 metabolites derived from oestrogen metabolism are associated with …
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Pathological response of breast cancer to neo-adjuvant chemotherapy at a single tertiary centre with no access to Trastuzumab
Introduction: Neoadjuvant chemotherapy (NACT) has firmly solidified its status as the gold standard in the treatment of breast cancer for eligible patients. While prevailing guidelines advocate for a combined approach involving chemotherapy and Trastuzumab for individuals with HER2-positive breast …
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Gene expression analysis in breast cancer
Breast cancer is the most common type of cancer among females, both in incidence and death. As meaningful biological understanding of the disease is confounded by the existence of various molecular groups and sub-groups, the challenge for targeted drug development may lie in understanding the …
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Aminoflavone Inhibits α6-integrin and Growth of Tamoxifen Resistant Breast Cancer
… 40% of estrogen receptor positive (ER+) breast cancer patients develop resistance to standard of care agent tamoxifen, while ER negative (ER-) breast cancer patients are intrinsically resistant to tamoxifen. Resistance often promotes metastasis, recurrence and death. Tumor-initiating …
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Molecular Determinants of Tumor Re-Initiation in Breast Cancer
<p>Cancer progression is characterized by the formation of tumors in primary organs and the subsequent re-formation of tumors in distant metastatic sites. The tumorigenic, or tumor-forming, capacity of cancer cells drives cancer along a continuum that includes primary tumor formation, metastatic …
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Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance
Breast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like …
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Estrogen Receptor -Dependent and Estrogen Receptor-Independent Pathways for Tamoxifen and 4-Hydroxytamoxifen-Induced Programmed Cell Death
One of the most common methods of breast cancer treatment is antiestrogen treatment. The therapeutic efficacy of the selective estrogen receptor modulator tamoxifen (TAM) in cancer therapy is thought to arise from its ability to compete with estrogens for binding to the ER. We show that TAM and its …
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Role of long non-coding RNAs in breast cancer progression
Breast cancer is the most common cancer in women worldwide. The molecular mechanisms underlying the disease have been extensively studied, leading to dramatic improvements in diagnostic and prognostic approaches. Despite the overall improvements in survival rate, numerous cases of death by breast …
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Hypoxia and Hypoxia-Inducible Factors in Normal and Malignant Breast Epithelium
Breast cancer treatment is based on tumor and patient related factors such as tumor stage, grade, hormonal status, HER2 status, patient age, and family history to name a few. It is today widely acknowledged that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. We …
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The perioperative setting as a platform for breast cancer biomarker development
Breast cancer is the most common cancer in women, with 2.3 million new cases globally in 2022 (1). ‘Neoadjuvant’ systemic therapy prior to surgery is the standard of care for stage II-III human epidermal growth factor receptor-2 (HER2) positive breast cancer. The identification of predictive …
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IGF2 Promotes Activation of Estrogen Receptors in Basal-like Breast Cancer Cells
… of IGF2 are important in the growth and differentiation of normal breast. In breast cancer (BC), IGF2 is initially stimulated by estrogen, progesterone and prolactin to regulate proliferation and cancer progression. These actions are mediated by the IGF-1R and insulin receptor A (IR-A) both …
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Chronic oxidative stress and susceptibility to renal carcinogenesis
… shared by multiple risk factors of kidney cancer. But there is no experimental evidence to show direct role of oxidative stress in kidney cancer. In this study, our main objective was to evaluate effect of H2O2-induced chronic oxidative stress on neoplastic transformation of normal human kidney …
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Genetic and Epigenetic Characterisation of Breast Tumours
… a large amount of genetic and epigenetic alterations, which are associated with e.g. tumour aggressiveness, prognosis, and response to therapy. The heterogeneity of breast tumours is reflected in the identification of at least five molecular subtypes named basal-like, luminal A, luminal B, …
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The Kras/Mapk Pathway and Ligand Independent Activation of Erα: Implications For The Treatment of Endometrial Cancer
<p>Hormonal therapy remains a first line option for the treatment of recurrent endometrial cancer (EC), however, many tumors demonstrate de novo or acquired resistance. Member kinases of the PI3K/AKT and Ras/MAPK pathways activate estrogen receptor α (ERα) independent of estrogen, however, few …
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Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer
The main function of erythropoietin (EPO) is in hematopoiesis where EPO stimulates increased proliferation, survival and differentiation of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different …
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Fração prevenível da atividade física e câncer: revisão sistemática da literatura
PREVENABLE FRACTION OF PHYSICAL ACTIVITY AND CANCER: SYSTEMATIC REVIEW OF LITERATURE. Introduction: The incidence of cancer, as well as other chronic diseases, has increased in recent years as a consequence of the modern lifestyle characterized by deregulated diet, sedentary lifestyle and exposure …
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