Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"ER-a"”.
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Association Analyses of Estrogen Receptor a Gene Polymorphisms with Bone Geometric Property at The Femoral Neck in Caucasian Nuclear Families
Osteoporosis is a serious public health problem, especially in the elderly. The most clinical importance of osteoporosis is its association with bone fragility. Bone geometry is an important risk factor for fracture, independent to BMD, and is genetically determined. However, genetic studies on …
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Fluorescent-Labeled Estrogen Receptors: Molecular Sensors of Receptor Structure and Function
… domain, we have created out of the ER a molecular sensor through which we can probe directly the conformational state of the receptor with high sensitivity. Thus, fluorophore-labeled ERs provide tools for studying receptor structure and function that nicely complement x-ray …
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Estrogene verzögern die Entwicklung der Transplantatvaskulopathie nach Herztransplantation - Experimentelle Untersuchungen im Kleintiermodell
Die Herztransplantation stellt heute oftmals die einzig effektive Therapie für Patienten mit Herzerkrankungen im Endstadium dar (Meiser et al., 1997). Seit dem routinemäßigen Einsatz von Cyclosporin A kann die akute Abstoßung besser kontrolliert werden. Die chronische Abstoßung, die sich bereits …
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Moskan í Reykjavík Suðurlandsbraut 76
Lokaverkefni Þetta snýst um að taka fyrir og fullvinna samkeppnistillögu Basalt arkitekta fyrir mosku í Reykjavík frá árinu 2015. Farið var í gegnum þá fasa hönnunar sem nemendur í byggingafræði við Háskólann í Reykjavík hafa tileinkað sér í námi. þ.e.a.s. frumhönnun, forhönnun, aðaluppdrætti og …
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Statistical methods for the search of high energy neutrinos from galactic sources in KM3NeT and ANTARES telescopes
Neutrino astronomy is a very young branch of astroparticle physics. More generally, at very high energies, astronomy with photons becomes useless because they are absorbed on the low energy photons from the cosmic background radiation. This limits the path length of a 10 TeV photon, for example, to …
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Radiotelemetry and Behavioral Ecology of Neonate Southern Pacific Rattlesnakes
<p>By externally glueing radiotransmitters to the dorsoposterior surface of seven neonate Southern Pacific Rattlesnakes, <em>Crotalus oreganus helleri,</em> I monitored the behavior and ecology of this understudied age-class and species. As an alternative to surgical implantation, external …
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Responding to response: An investigation of ESL writing revision practices in response to teacher feedback
Although teacher feedback is a common element of process based ESL writing classrooms, the effect that teacher feedback has on subsequent student revisions is largely undetermined. In this study, the relationship between written comments and student revisions was investigated. The way students …
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Iceland : transition to clean energy, limitations of the electric transmission system
Tilgangur verkefnisins er að reyna að kortleggja hvaða áhrif orkuskipti í samgöngum og iðnaði munu hafa á flutningskerfi raforku í framtíðinni. Skilgreindar voru tvær sviðsmyndir þar sem mismunandi stig orkuskipta var skilgreint og orkuþörfin metin fyrir hvora sviðsmynd. Út frá orkuþörfinni var …
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Application of formal safety assessment for ship hull vibration modelling
… research are associated with risk modelling under circumstances where high levels of uncertainty exist. Following the identification of research needs, this PhD thesis has developed several analytical models for the application of Formal Safety Assessment (FSA). Such mode quently demonstrated by …
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Studies towards the in vivo inhibition of oligosaccharyl transferase
… is an important process because of the great diversity of glycoproteins that can be produced by the introduction of different oligosaccharide sequences. Our group has made significant progress in the study of asparagine-linked glycosylation. This process is catalyzed by oligosaccharyl transferase …
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Testing the limits of nonlocality
The nascent field of quantum information offers the promise of dramatic speed increases for certain types of computation and logical protocols which are classically impossible. The phenomenon of nonlocality is fundamental to this study, and polarization-entangled photons o er a clean, bright, and …
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Structure, Mechanism and Chemical Modulation of the Protein Kinase-nuclease Dual-enzyme IRE1
Perturbations that derail the proper folding and assembly of proteins in the endoplasmic retriculum (ER) cause misfolded protein accrual in the ER – a toxic condition known as ER stress. The Unfolded Protein Response (UPR) is a signaling system evolved to detect and rectify ER stress. The work I …
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Stochastic modeling of expansion and shrinkage phenomena in starch based melts during extrusion
… for production of expanded products. However, variability in multiple input parameters can lead to significant variations in the end product which becomes a concern for process control and efficiency in industries. This study was focused on understanding the uncertainty in input parameters …
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Characterisation of the PQ-loop repeat membrane protein family in arabidopsis thaliana
This thesis describes the characterisation of the PQ-loop repeat family, a novel family of membrane proteins from Arabidopsis thaliana. The family consists of six members (AtPQL1-6) all predicted to contain seven transmembrane segments and two copies of the PQ-loop domain. The repeated PQ-loop …
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Responsividade e eficiência do uso de fósforo de cultivares de soja
… de cultivares com maior habilidade de crescer e produzir sob condições de solos com disponibilidades reduzidas de P, ou seja, cultivares mais eficientes na utilização desse mineral seria uma estratégia para reduzir o efeito desse estresse na cultura. Assim, o objetivo deste trabalho foi …
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Efficient design and optimized crash-consistency support for hybrid memory systems
Hybrid memory systems (HMSs) pair different memory technologies within a uni ed main memory to combine the best features of those technologies, such as performance with capacity and durability. However, HMSs do not provide a cost-effective solution as a memory subsystem that can accommodate an …
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Multi agent system for web database processing, on data extraction from online social networks.
In recent years, there has been a ood of continuously changing information from a variety of web resources such as web databases, web sites, web services and programs. Online Social Networks (OSNs) represent such a eld where huge amounts of information are being posted online over time. Due to the …
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Mitigating high-temperature, high-pressure hydrogen attack
High-temperature, high-pressure hydrogen attack is a degradation mechanism that threatens the integrity of critical components in re fineries and petrochemical plants. This phenomenon was discovered in the early twentieth century, however, the experience-based recommended practice used to design …
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Untersuchungen pflanzlicher Futterzusätze mit fraglich HRT-alternativen Wirkungen bezüglich ihres Einflusses auf die Mammae weiblicher, ovarektomierter Ratten im Vergleich zu Placebo-, Östradiol- und Raloxifenbehandlung
Aufgrund der Häufigkeit der teilweise ernsthaften perimenopausalen Symptome und des erhöhten Risikos, unter HRT Schlaganfälle, KHK, venöse Thrombosen und Mammakarzinome zu entwickeln, sind wir interessiert, sichere Alternativen zur hormonellen Ersatztherapie zu finden. Aus diesem Grund haben wir …
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A neuron within a neuron: the effect of narrow axonal ER tubules on molecular movement
Hereditary spastic paraplegias (HSP) are a group of diseases showing degeneration of lower motor axons. A common cause of HSP is the mutation of proteins that shape the tubular endoplasmic reticulum (ER). The architecture of the ER tubular network that extends through axons is therefore likely to …
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