Global ETD Search
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Showing 1 to 5 of 5 for “"ER-Quality Control"”.
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Protein quality control in the mammalian endoplasmic reticulum
Quality control is an important part of protein biogenesis. Aberrant proteins must be destroyed before they aggregate and cause deleterious effects. Failure to do so can result in cell death or malfunction and, ultimately, disease. Quality control involves the recognition of misfolded proteins and …
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The Effect of Stability and Surface Charge Distribution on Secretion of Bovine Pancreatic Trypsin Inhibitor From Yeast
Biophysical characterization of the BPTI mutants shows that removal of charges results in a drop in the effective number of ionic binding sites, as analyzed by binding of the molecule to a cation exchange column. Removal of the charge on the uncharged face of the molecule results in a dramatic …
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Serpin polymers enforce molecular filtration in the endoplasmic reticulum
… and cause disease. Alpha1-antitrypsin is the serine protease inhibitor (serpin) that is secreted mainly by hepatocytes and acts in lungs where its major function is to inhibit neutrophil elastase. Neuroserpin is a serine protease inhibitor expressed in the nervous system. Mutations in these two …
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Generation and characterization of BAP-deficient cell lines
… expressed integral membrane proteins of the ER. In B-lymphocytes, they transiently bind to the TM domains of mIgD and mIgM, both of which are BCR subunits. BAP29 and BAP31 are discussed to play a role in controlling ER export of certain TM proteins by an unknown mechanism. In particular, BAPs …
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Delineating the Mechanisms of Misfolded Endoplasmic Reticulum (ER) Luminal Protein Retrotranslocation for ER-Associated Degradation
… are synthesized in the endoplasmic reticulum (ER) where they undergo post-translational modifications, oxidative folding, and subunit assembly in tightly monitored processes. An ER quality control (ERQC) system oversees protein maturation and ensures that only those reaching their native state …