Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"ER-Associated Degradation"”.
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Delineating the Mechanisms of Misfolded Endoplasmic Reticulum (ER) Luminal Protein Retrotranslocation for ER-Associated Degradation
… are synthesized in the endoplasmic reticulum (ER) where they undergo post-translational modifications, oxidative folding, and subunit assembly in tightly monitored processes. An ER quality control (ERQC) system oversees protein maturation and ensures that only those reaching their native state …
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Utilizing Drosophila S2 Cells as a Model System to Determine Underlying Mechanisms of ER-associated Degradation
Proper folding of nascent polypeptides is vital to maintain cellular homeostasis; proteins that adopt aberrant confirmations are selectively degraded through a multi-step process known as endoplasmic reticulum-associated degradation (ERAD). Underlying mechanisms for ERAD of membrane proteins, …
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Sequential Actions of VCP/p97 and the Proteasome 19S Regulatory Particle in Sterol-Accelerated, ER-Associated Degradation of HMG CoA Reductase
Accelerated endoplasmic reticulum (ER)-associated degradation (ERAD) of the cholesterol biosynthetic enzyme HMG CoA reductase results from its sterol-induced binding to ER membrane proteins called Insig-1 and Insig-2. This binding allows for subsequent ubiquitination of reductase by …
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Characterization of a Novel NPC1I1061T Knock-in Mouse Model of Niemann-Pick Type C1 Disease
… Type C (NPC) disease is a fatal pediatric cholesterol storage disease that is caused by mutations in either the <italic>npc1</italic> or <italic>npc2</italic> genes. Loss of function of either gene results in toxic storage of free cholesterol in the lysosomes due to a cholesterol trafficking …
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The Endoplasmic Reticulum Udpase ENTPD5 Promotes Cancer Cell Growth and Survival in the PI3K/PTEN
… Mutations activating AKT are commonly observed in human cancers. Activation of AKT and downstream PI3 Kinase signaling promotes protein translation, resulting in increased protein flux into ER; this will lead to decreased efficiency of protein folding and accumulation of unfolded proteins …
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Herp Reduces ER Calcium Content by Proteasomal Degradation of SERCA
Herp, an endoplasmic reticulum (ER) stress inducible protein, reduces ER Ca2+ content in neurons and prevents their apoptosis. An understanding of the mechanism by which Herp decreases ER Ca2+ content requires studies of Herp interacting proteins, which could be SERCA and the proteasome. Herp may …
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Studies on the mechanisms that contribute to the endoplasmic reticulum quality control system in Saccharomyces cerevisiae
The Endoplasmic Reticulum (ER), which serves as a site for protein biogenesis in budding yeast, contains a quality control system that ensures that only proteins that have attained a native conformation are deployed to other destinations in the cell. In order to gain insight into the mechanisms …
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Regulation of Protein Degradation at the Endoplasmic Reticulum
Endoplasmic reticulum (ER) associated degradation (ERAD) is important for removing damaged or misfolded proteins at the ER membrane, and is central to the physiological regulation of proteins such as HMG-CoA Reductase (HMGCR), the rate limiting enzyme in cholesterol biosynthesis. Under sterol rich …
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Hrd1 Partners In Endoplasmic Reticulum-Associated Degradation
… cellular pathways that regulate the turnover of short-lived, misfolded proteins. A main component of PQC is Endoplasmic Reticulum (ER)-Associated Degradation (ERAD), which controls the degradation of proteins synthesized in the ER. Aberrations in ERAD have been linked to malignancies such …
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Topological Regulation of TM4SF20
Transmembrane proteins must adopt proper topology to perform their functions. It was previously demonstrated that ceramide regulates TM4SF20 (transmembrane 4 L6 family 20) by altering the topology of the transmembrane protein, but the underlying mechanism remains obscure. This regulatory mechanism, …
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Molecular Adaptation of Pancreatic Beta-Cell Function During Endoplasmic Reticulum Stress
… concentrations in the endoplasmic reticulum (ER). During this process, reactive oxygen species (ROS) may originate as byproducts from the oxidative protein folding machinery in the ER, especially during an unfolded protein response (UPR). Using a beta-cell line (MIN6) and mouse islets, …
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Ubiquitin E3 ligase mediated regulation of HMG-CoA Reductase
Loss-of-function genetic screens are a powerful approach to identify the genes involved in biological processes. For nearly a century, forward genetic screens in model organisms have provided enormous insight into many cellular processes. However, the difficulty in generating and recovering …
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CHEMICAL APPROACHES TOWARD NEW PERSPECTIVES IN DRUG DISCOVERY: NATURAL PRODUCTS AND BIOACTIVE HITS AS AN INSPIRATION
The quest for novel therapeutics in drug discovery requires a multifaced approach, and innovative strategies that bridge the gap between nature’s diverse chemical landscape and the evolving demands of modern medicine. By employing a synergy between total synthesis, innovative molecule design and …