Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"ER targeting"”.
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Biogenesis and Traffic of the Potassium Channel
<p>Excitability of nerve and muscle cells depends on the number and the types of ion channels expressed at the plasma membrane. This work examines aspects of biogenesis and traffic of the Shaker voltage-gated potassium channel. Shaker is an oligomeric, polytopic membrane protein and, as such, its …
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Post-translational Insertion of a Small Tail-Anchored Protein into the Membrane of the Endoplasmic Reticulum
Proteins destined for membrane insertion can be targeted to and inserted into the endoplasmic reticulum (ER) either during synthesis (cotranslationally) or after their synthesis is completed (post-translationally). While the cotranslational pathway is well characterized, much less is known about a …
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Characterization of the glycosylation and signal peptide sequences within the vaccinia virus m2 protein and influence on ERK1/2 and NF-kB activation
… Wild-type vaccinia virus (VV) strains subvert the immune response by expressing proteins that interfere with nuclear translocation of NF-κB. In contrast, infection with an attenuated strain, MVA, results in host cell NF-κB activation. Inclusion of the M2 gene of VV into the attenuated MVA …