Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"ER stress response"”.
-
Unveiling the Intercompartmental Signaling Axis: Mitochondrial to ER Stress Response (MERSR) and Its Impact on Proteostasis
… for cellular health. During times of protein stress, cells deploy unique defense mechanisms to achieve resolution. Our previous research uncovered a cross-compartmental Mitochondrial to Cytosolic Stress Response (MCSR), a unique stress response activated by the perturbation of mitochondrial …
-
Coordination of the endoplasmic reticulum stress response and lipid metabolism in plants
The endoplasmic reticulum (ER) stress response is an important signal transduction pathway that senses ER stress caused by misfolded proteins or increased secretory protein traffic and induces molecular chaperone expression to counter such stress. The response has been well characterized in yeast …
-
Role of SLMAP in Endoplasmic Reticulum Stress and Unfolded Protein Response
… components of the sarco/endoplasmic reticulum (ER/SR). Disruptions in homeostatic balance of these proteins and calcium regulation results in activation of ER stress response. Sarcolemmal membrane-associated proteins (SLMAPs) are found in cell membrane, SR/ER, and mitochondria. Overexpression of …
-
The intrinsic role of SOCS1 in intestinal epithelial cells
… Socs1ΔIEC mouse model suggests that lethal ulcerative colitis might be driven by Paneth and goblet cell defects, like those seen in inflammatory bowel disease patients and mouse models with defective genes regulating autophagy and endoplasmic reticulum (ER) stress response. Ensuing dysbiosis …
-
Investigating the role of transcription factor Nrf2 in the pathogenesis of NAFLD
… (NASH) is thought to occur through interacting mechanisms of cellular stress. Lipids accumulate within hepatocytes, making cells more susceptible to insult and less able to respond to challenges, leading to progression from simple steatosis to inflammation. <br/><br/>Endoplasmic …
-
The study of Murine double minute-2 (Mdm2) in regulating neuronal activity-dependent protein translation
… connection is crucial for establishing proper neural circuit excitability throughout development stages, and serves an essential role in maintaining excitatory/inhibitory (E/I) balance in the central nervous system. In this thesis, I discovered potential signaling pathways that contribute to …
-
Environmental stimuli shape adaptive immunity by enhancing T helper cell differentiation and the germinal centre response
Immune cells have evolved to respond to external danger signals and to incorporate information about environmental cues to adapt their differentiation and effector function. Because of this, it is important that immune cells are studied in the context of their surroundings. In this thesis, I …
-
Neuroprotective effects of incretin mimetics upon chronic endoplasmic reticulum (ER) stress : implications for novel therapeutic pathways and opportunities in Alzheimer's disease
… evidence suggests that incretin mimetics exert neuroprotective and neurorestorative effects across a range of experimental models of neuronal degeneration. In a recent pilot clinical trial, Liraglutide rescued the decline of the cerebral glucose consumption in Alzheimer’s disease (AD) …
-
Investigating WDR12 as a Therapeutic Target in Breast Cancer
Breast cancer is the most diagnosed and lethal cancer globally in women. Presently, there is a need for novel targets for the development of improved therapeutics. Data mining through genetic screens suggests that the ribosome biogenesis protein WDR12 is essential for breast cancer cell …
-
Interactions of shiga-like toxin-2 (Stx-2) from Escherichia coli O157:H7 and the Bcl-2 family of proteins during host cell programmed cell death
… a major contributor to the pathogenesis of Escherichia coli 0157:H7. Prior reports suggest that Stx-2 increases necrosis and apoptosis of a variety of host cells including those of endothelial origin as well as immune cells such as neutrophils (156). However, the role Stx-2 plays in delayed …
-
Characterization of the Molecular Mechanisms of Xenobiotic-Induced NRF2 Activation for Disease Prevention and Intervention
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is the master regulator of the cellular antioxidant response upon exposure to xenobiotics. In addition, NRF2 induces the expression of genes involved in drug metabolism, protein homeostasis, anabolic metabolism, …
-
Human Cytomegalovirus Us17 Locus Fine-Tunes Innate And Intrinsic Immune Responses
<p>HCMV employs numerous strategies to combat, subvert, or co-opt host immunity. One evolutionary strategy for this involves "capture" of a host gene and then its successive duplication and divergence, forming a gene family, many of which have immunomodulatory activities. The HCMV US12 family …
-
Ire1 regulates cyp11a1 transcription to mediate steroidogenesis in the ovary
CYP11A1 transcriptional activation in response to gonadotropin hormones is critical to maintain fertility and support pregnancy. Therefore, we are interested in identifying factors that regulate CYP11A1 transcription. Our laboratory has identified several signaling proteins that activate CYP11A1 …
-
Study of the Cellular Role of GRP78/BiP mono-ADP-ribosylation in UPR and Cancer
Mono-ADP-ribosylation is a reversible post-translational protein modification that modulates the function of proteins involved in different cellular processes, including signal transduction, protein transport, transcription, cell cycle regulation, DNA (deoxyribonucleic acid) repair and apoptosis. …
-
Regulation of Pkr Activation by Pact and Trbp In Response to Stress Signals
<p> PKR (protein kinase, RNA activated) is an interferon (IFN)-induced serine-threonine protein kinase, which plays a crucial role in IFN's antiviral and antiproliferative actions. In addition, PKR plays a regulatory role in signal transduction leading to apoptosis in response to a variety of …
-
A Novel Subfamily of Three StAR-Related Lipid Transfer Proteins That Are Differentially-Regulated and Function in Intracellular Cholesterol Metabolism
<p>This thesis describes the discovery, cloning, and initial characterization of StarD4, sterol-regulated gene encoding a StAR-related lipid transfer (START) protein, and its close homologues, StarD5 and StarD6. StarD4 was identified using cDNA microarrays, as liver StarD4 expression decreased …
-
Characterization and Treatment of A Novel Mouse Model of Tsc-Associated Autism
<p>Tuberous sclerosis complex (TSC) is a dominant tumor suppressor disorder caused by mutations in either <em>TSC1 </em>or <em>TSC2.</em> The proteins of these genes form a complex to inhibit the mammalian target of rapamycin complex 1 (mTORC1), which controls protein translation and cell growth. …
-
An In Vivo Characterization of the Functional Role of Two Novel Genes: StARD5 and ADAM11
<p>Regulation of cholesterol levels within cells and organisms is crucial for their survival. Maintenance of cellular cholesterol homeostasis occurs mainly at the transcriptional level, via the Sterol Regulatory Element Binding Proteins (SREBP), the Liver X Receptors (LXR), and the Unfolded Protein …
-
EFFECT OF COMBINATION OF THE MAMMALIAN LIGNAN, ENTEROLACTONE, WITH TYROSINE KINASE INHIBITORS ON MARKERS OF HEPATIC FIBROSIS
… suggests multi-target drugs might have therapeutic potential. This dissertation research aimed to confirm the antifibrotic effects of the combination of the bioactive mammalian lignan, enterolactone (ENL), and selected tyrosine kinase inhibitors (TKIs) and to explore whether these effects …
-
Role of ATF4 in Neuronal Death Mediated by DNA Damage, Endoplasmic Reticulum Stress and Ischemia-Hypoxia
… points to a key role of endoplasmic reticulum (ER) stress in chronic and acute neurodegenerative diseases. Indeed, markers of ER stress are common features of neurons destined to die in these conditions. In the present study we demonstrate that PUMA, a BH3-only member of the Bcl-2 family is …
Page 1 of 2