Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 184 for “"ER stress"”.
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Identification of a Novel Regulator of ER Stress-Induced Apoptosis
… of a multicellular organism is reliant upon proper cell and organelle function, and the tight regulation of cell number. The endoplasmic reticulum (ER) is the cellular compartment where membrane and secretory pathway proteins are folded and modified for transport within or outside of the cell. …
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Role of ATG 5 in ER stress-induced apoptosis in meniscus.
Osteoarthritis (OA) is a degenerative disorder of the whole joint that affects 23 million older adults in the US. Obesity, one of the major risk factor for OA, is associated with increased circulating free fatty acids (FFAs). The overall objective of this project was to examine the effect of these …
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Induktion von myokardialem ER-Stress durch biomechanische Last und neurohumorale Stimulation.
Myokardiale Hypertrophie ist ein wichtiger Anpassungsmechanismus auf viele physiologische und pathologische Stimuli. Sie kann sich zu einer pathologischen Hypertrophie entwickeln, die häufig zu Herzversagen führt. Hypertrophie ist mit einer gesteigerten Proteinsynthese, darunter viele …
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Inhibition of pancreatic cancer progression through EMT inhibition and induction of ER stress
Pancreatic cancer is a devastating disease with a current overall 5-year survival rate of only 10%, making it the deadliest cancer. The dismal treatment outcome of pancreatic cancer is largely attributed to its highly metastatic and chemo-resistant nature. Cancer cell epithelial to mesenchymal …
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BETACORONAVIRUSES OPTIMIZE REPLICATION BY BALANCING ANTAGONISM OF INNATE IMMUNE RESPONSES AND ER STRESS RESPONSES
Betacoronaviruses have emerged as a major threat to human health in the 21st century, although our understanding of their interactions with human cells remains limited. To better understand the determinants of human betacoronavirus infection and to identify potential therapeutic strategies, we …
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Up-regulation of junctophilin-2 prevents ER stress and apoptosis in hypoxia/reoxygenation-stimulated H9c2 cells
… disease is the leading cause of death, and reperfusion which can restore blood flow is the primary therapy. However, reperfusion can induce further damage to cardiomyocytes, a condition described as ischemia-reperfusion (I/R) injury. I/R is now recognized as a combination determining the final …
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Unveiling the Intercompartmental Signaling Axis: Mitochondrial to ER Stress Response (MERSR) and Its Impact on Proteostasis
… for cellular health. During times of protein stress, cells deploy unique defense mechanisms to achieve resolution. Our previous research uncovered a cross-compartmental Mitochondrial to Cytosolic Stress Response (MCSR), a unique stress response activated by the perturbation of mitochondrial …
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INTEGRATED MOLECULAR INVESTIGATIONS OF MYRF AND SFRP2: UNVEILING REGULATORY MECHANISMS OF ER STRESS AND ECM REMODELLING IN PANCREATIC CANCER
… lethality is the significant intratumor cell diversity, highlighting the need for enhanced molecular understanding. Indeed, PDACs are ensembles of three different subtypes with distinct morphology and gene expression programs that coexist in variable proportions in every tumor. Following the …
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HORMONE EPIMERS REGULATE ER STRESS AND CORE REGULATORY GENES: NETWORK ANALYSIS WITH APPLICATIONS TO GLIOMA AND CHRONIC PRESSURE ULCERS
<p>DHEA has been determined to have medically significant activity and is the parent compound to the more active metabolites; 17α-AED, 17β-AED and 17β-AET, which exhibit strong biological activity that has been attributed to androgenic, estrogenic or anti-glucocorticoid activity in vivo and in …
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ER Stress is Linked to the Regulation of Hepatic Gluconeogenesis and Phosphatidylinositol 3-kinase/Akt Signaling Post Burn Injury
Burn injury is a severe form of trauma that causes changes in glucose metabolism. Glucose metabolism is controlled during early burn injury but later results in stress induced diabetes. We have shown that this is due to differential regulation of the insulin signaling pathway in the liver.
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Neuroprotective effects of incretin mimetics upon chronic endoplasmic reticulum (ER) stress : implications for novel therapeutic pathways and opportunities in Alzheimer's disease
… evidence suggests that incretin mimetics exert neuroprotective and neurorestorative effects across a range of experimental models of neuronal degeneration. In a recent pilot clinical trial, Liraglutide rescued the decline of the cerebral glucose consumption in Alzheimer’s disease (AD) …
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Characterization of The Role of Carma3 In Endoplasmic Reticulum Stress-Induced Nf-Κb Activation
<p>Endoplasmic reticulum (ER) stress-induced inflammation plays an important role in the progression of many diseases, such as type II diabetes, insulin resistance, cancers, and so on. NF-κB is believed to be a central regulator of ER stress-induced inflammation. However, studies on how ER stress …
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Lipid signalling dynamics of palmitate-induced endoplasmic reticulum stress in skeletal muscle
… identification of the aetiological processes underlying this disease imperative. Endoplasmic reticulum (ER) stress has emerged as a potential mechanism driving the pathogenesis of obesity and T2DM. Palmitate, the predominant saturated fatty acid elevated in the blood plasma of obese individuals, …
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Investigating the role of transcription factor Nrf2 in the pathogenesis of NAFLD
… (NASH) is thought to occur through interacting mechanisms of cellular stress. Lipids accumulate within hepatocytes, making cells more susceptible to insult and less able to respond to challenges, leading to progression from simple steatosis to inflammation. <br/><br/>Endoplasmic …
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Investigating the role of endoplasmic reticulum stress in neutrophils during tumour initiation
… suppressive and tumourpromoting neutrophils were found enriched in the tumour microenvironment, suggesting their role in driving the development of cancer. However, the role of neutrophils during tumour initiation is less clear. Studies in zebrafish tumour initiation models suggest that …
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Role of ATF4 in Neuronal Death Mediated by DNA Damage, Endoplasmic Reticulum Stress and Ischemia-Hypoxia
… points to a key role of endoplasmic reticulum (ER) stress in chronic and acute neurodegenerative diseases. Indeed, markers of ER stress are common features of neurons destined to die in these conditions. In the present study we demonstrate that PUMA, a BH3-only member of the Bcl-2 family is …
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HIV Protease Inhibitors Trigger Lipid Metabolism Dysregulation Through Endoplasmic Reticulum Stress and Autophagy
… components of Highly Active Antiretroviral Therapy (HAART). HIV PIs are extremely effective at suppressing viral load, but have been linked to lipodystrophy and dyslipidemia, which are major risk factors for cardiovascular disease. Recent studies indicate that activation of endoplasmic …
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Altered Responses to Endoplasmic Reticulum Stress In Pancreatic Cancer
… represents the fourth most common cause of cancer-associated death in the United States. Little progress has been made in understanding how proteotoxic stress affects rapidly proliferating pancreatic tumor cells. Endoplasmic reticulum (ER) stress occurs when protein homeostasis in the ER lumen …
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Role of SLMAP in Endoplasmic Reticulum Stress and Unfolded Protein Response
… components of the sarco/endoplasmic reticulum (ER/SR). Disruptions in homeostatic balance of these proteins and calcium regulation results in activation of ER stress response. Sarcolemmal membrane-associated proteins (SLMAPs) are found in cell membrane, SR/ER, and mitochondria. Overexpression of …
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Metabolic Regulation of Mtor Activation and Endoplasmic Reticulum Stress In The Heart
… by increasing the size of myocytes. Whether changes in metabolism regulate the structural remodeling process is unknown. A likely candidate for a link between metabolism and growth in the heart is the mammalian target of rapamycin (mTOR), which couples energy and nutrient metabolism to …
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