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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 47 for “"ER positive"”.

  1. Combined Inhibition of Ddr1 and Cdk4/6 Induces Synergistic Effects In Er-Positive, Her2-Negative Breast Cancer With Pik3Ca/Akt1 Mutations

    shariati, maryam, <p>0000-0003-1897-1553</p>2021

    … INHIBITION OF DDR1 AND CDK4/6 INDUCES SYNERGISTIC EFFECTS IN ER-POSITIVE, HER2-NEGATIVE BREAST CANCER WITH <em>PIK3CA/AKT1</em> MUTATIONS</strong></p> <p>Maryam Shariati, M.S. Advisory Professor: Funda Meric-Bernstam, M.D.</p> <p>Molecular alterations in the phosphatidylinositol 3‑kinase …

    uthsc Repository record

  2. Comprehensive gene assessment of estrogen receptor positive breast cancers reveals that HER2 positive status plays an important role in resistance to neoadjuvant letrozole

    Webber, Victoria LouiseThe University of Edinburgh2019

    Background The ER positive/ HER2 positive molecular subtype accounts for up to 10% of all breast cancers, these cancers have a worse prognosis than ER positive/ HER2 negative breast cancers. There is considerable evidence that ER positive/ HER2+ positive cancers exhibit resistance to endocrine …

    edinburgh Repository record

  3. Expression of Human Estrogen Receptor and Studies of Estrogen-Mediated Transcription and Apoptosis

    Zhang, ChengchengUniversity of Illinois at Urbana-Champaign2015

    … each induce apoptosis in stably transfected hER positive HeLa-ER5 cells. Using transient transfections and a reporter system to measure p38 activity, we show that E2 induces the p38 activity 12--36 fold in several ER positive cell lines, while OHT induces p38 activity 2--5 fold. A selective …

    uiuc Repository record

  4. Androgen Receptor: A Complex Therapeutic Target in Breast Cancer

    Asemota, Sarah Tinuade2025

    <p>Breast cancer is classified based on the expression of three markers estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor (HER2). Breast cancers that express these targets are classified as hormone receptor (HR) positive breast cancer and the tumors that lack …

    tenn-hsc Repository record

  5. Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance

    Lehn, SophieDepartment of Laboratory Medicine, Lund University2013

    Breast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like …

    lund Repository record

  6. Effects of Oestrogen Receptor Status of Women with Breast Cancer Treated with Tamoxifen at University Teaching Hospital and Cancer Diseases Hospital

    Nkuliyingoma, AnastaseThe University of Zambia2015

    The main objective of this study was to determine the prevalence of oestrogen receptor-negative breast cancers at UTH and CDH and its impact on tamoxifen management. The specific objectives of the study were to determine the prevalence of oestrogen receptor negative of breast cancer patients; to …

    zimbabwe Repository record

  7. Effects of Oestrogen Receptor Status of Women with Breast Cancer Treated with Tamoxifen at University Teaching Hospital and Cancer Diseases Hospital

    Nkuliyingoma, AnastaseThe University of Zambia2015

    The main objective of this study was to determine the prevalence of oestrogen receptor-negative breast cancers at UTH and CDH and its impact on tamoxifen management. The specific objectives of the study were to determine the prevalence of oestrogen receptor negative of breast cancer patients; to …

    zambia Repository record

  8. Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer

    Larsson, Anna-MariaCenter for Molecular Pathology, Faculty of Medicine2012

    The main function of erythropoietin (EPO) is in hematopoiesis where EPO stimulates increased proliferation, survival and differentiation of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different …

    lund Repository record

  9. Angiotensin-(1-7): A Peptide Hormone Inhibitor for the Treatment of Breast Cancer Targeting the Tumor Microenvironment

    Cook, KatherineWake Forest University2010

    In 2009, 192,000 new cases of breast cancer were diagnosed in the United States and over 40,000 American women died from breast cancer, emphasizing the severity of the breast cancer epidemic. Recent advances in molecular profiling of breast tumors have identified three clinically-relevant …

    wfu Repository record

  10. Neoadjuvant endocrine therapy for estrogen receptor positive breast cancer in an African setting

    Molabe, HunadiDivision of General Surgery2022

    Background Several studies have reported response rates for ER positive cancers on neoadjuvant endocrine therapy (NET), with lower toxicity compared to neoadjuvant chemotherapy (NCT). During the first wave of the COVID pandemic, clinician preference for NET increased significantly, buying time for …

    cape-town Repository record

  11. Mathematical Modeling of Therapies for MCF7 Breast Cancer Cells

    He, WeiVirginia Tech2021

    Estrogen receptor (ER)-positive breast cancer is responsive to a number of targeted therapies used clinically. Unfortunately, the continuous application of any targeted therapy often results in resistance to the therapy. Our ultimate goal is to use mathematical modelling to optimize alternating …

    vt Repository record

  12. The Development of the Prognostic Breast Cancer Model PREDICT

    Grootes, IsabelleUniversity of Cambridge2023

    … for patients with early invasive breast cancer. Since its development in 2010, the model has shown a variety of prognostic outcomes among numerous studies. Due to improvements in breast cancer survival and advancements in cancer treatments, the model might be outdated and could lead to …

    cambridge Repository record

  13. Chronic oxidative stress and susceptibility to renal carcinogenesis

    Mahalingaiah, Prathap Kumar SalakatteTexas Tech University2015

    … shared by multiple risk factors of kidney cancer. But there is no experimental evidence to show direct role of oxidative stress in kidney cancer. In this study, our main objective was to evaluate effect of H2O2-induced chronic oxidative stress on neoplastic transformation of normal human kidney …

    ttu Repository record

  14. Cell Cycle Regulatory Roles of Estrogen Receptor Alpha (Erα) In Breast Cancer Cells

    JavanMoghaddam, Sonia2011

    … studies have shown that Estrogen Receptor alpha (ERα) is an important indicator for diagnosis, prognosis and treatment of breast cancers. However, the question remains as to the role of ERα in the cell in the presence versus absence of 17-β estradiol In this dissertation the role of ERα in both …

    uthsc Repository record

  15. Resolving Intra-Tumoral Heterogeneity of Breast Cancer Using Single-Cell Multi-Omics

    Yan, Yun, <p>0000-0002-3701-9608</p>2026

    <p>Breast cancer is a highly heterogeneous disease characterized by diverse genetic, transcriptional, and epigenetic landscapes. Understanding how intra-tumoral heterogeneity (ITH) influences therapeutic response and drives tumor evolution remains a central challenge in cancer biology. Here, we …

    uthsc Repository record

  16. Cytochrome P450 mRNA profile in human breast cancer cell lines.

    Warasiha, BenjamartRobert Gordon University2008

    … P450 enzymes (P450s) are involved in cancer development and treatment due to their roles in the oxidative metabolism of various compounds, both endogenous (e.g. oestrogen) and exogenous (e.g. tamoxifen). Intermediate P450 metabolites derived from oestrogen metabolism are associated with …

    rgu Repository record

  17. Tamoxifen metabolites can target both aromatase and estrogen receptors

    Liu, Jinzhong2015

    Breast cancer remains the most prevalent malignancy diagnosed in women. More than two thirds of all diagnosed breast cancers are estrogen receptor (ER)-positive and are dependent on estrogen signaling. Drugs for the treatment of ER-positive breast cancer can be divided into three classes: selective …

    iupui Repository record

  18. The role of tissue inflammation in Kenyan women with breast cancer

    Abdulrehman, Shahin SayedDepartment of Pathology2022

    Background The immune landscape of breast cancer (BC) molecular subtypes from Sub Saharan Africa is understudied and findings are mainly extrapolated from studies in Caucasians. The objective of this study was to describe the cellular and signalling milieu of BC tumour microenvironment and its …

    cape-town Repository record

  19. Micrornas That Affect Breast Cancer Growth, Metastasis And Estrogen-Independent Growth

    Wu, Hailong2009

    … MICRORNA-205 IS A TUMOR SUPPRESSOR IN BREAST CANCER Major Professor: Dr. Yinyuan Mo MicroRNAs as a class of novel negative regulators have drawn intensive attention since their existence in mammals was discovered in 2001. As endogenous small non-coding RNAs, miRNAs are capable of silencing gene …

    siu-theses Repository record

  20. Ανοσοϊστοχημική μελέτη της έκφρασης των οιστρογονικών υποδοχέων στους όγκους των ωοθηκών με μονοκλωνικά αντισώματα (με την μέθοδο αβιντίνης-βιοτίνης)

    Adamopoulos, Spyridon, Αδαμόπουλος, ΣπυρίδωνUniversity of Ioannina1990

    … cysts of the ovaries, using the avidin-biotin-peroxidase complex (ABC) method and monoclonal anti-ER antibodies. The estrogen receptors (ER) were localized in 35% of cystadenomy in 67% of tumors of borderline malignancy and in 66% of carcinomas; also in 67% of sex cord-stromal tumors, in 29% of …

    greece Repository record

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