Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"ER morphology"”.
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Cornichon Proteins: Unexpected Roles in Plant Pathogen Infection, ER Morphology Maintenance and Pollen Development
Cornichon (CNI) proteins are a conserved family of proteins among eukaryotes, from Erv14 in the yeast Saccharomyces cerevisiae to CNI homologs (CNIHs) in mammals and plants. Erv14 functions as a cargo receptor of coat protein complex II (COPII) for protein trafficking from the endoplasmic reticulum …
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Identifying the Molecular Cause of Extreme Endoplasmic Reticulum Dilation in Pediatric Osteosarcoma and Its Relationship to the Disease
<p>Pediatric osteosarcoma tumors are characterized by an unusual abundance of grossly dilated endoplasmic reticulum and an immense genomic instability that has complicated identifying new effective molecular therapeutic targets. Here we report a novel molecular signature that encompasses the …
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Endoplasmic Reticulum Morphoregulation Modulates Ca2+- Driven Brain Cell Functions
… integrity of the Endoplasmic Reticulum (ER) have been associated with various neuronal pathologies, with mutations in some ER morphogens causing motor neurone diseases. The selective vulnerability of long axons highlights the significance of their extensive ER tubule-containing periphery …
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Serpin polymers enforce molecular filtration in the endoplasmic reticulum
… and cause disease. Alpha1-antitrypsin is the serine protease inhibitor (serpin) that is secreted mainly by hepatocytes and acts in lungs where its major function is to inhibit neutrophil elastase. Neuroserpin is a serine protease inhibitor expressed in the nervous system. Mutations in these two …
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Beyond membrane curvature: Clade 6 reticulons and their role within the plant endoplasmic reticulum
The endoplasmic reticulum (ER) is a dynamic organelle with multiple functions. It is comprised of distinct morphological domains. Regulation of this morphology and its dynamics are mediated by several highly conserved families of proteins, namely the reticulon (RTN) proteins responsible for …
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Endoplasmic Reticulum Dynamic Structural Changes in Neurons: The Fission-Fusion Phenomena
The endoplasmic reticulum (ER) is crucial for protein synthesis and protein maturation, is involved in cell stress and serves in neurons as the major intracellular Ca2+ store. Neuronal ER forms a continuous network of cisterns and tubules extending from soma to a subset of dendritic spines. The …