Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"ERβ"”.
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The Molecular Components of Estrogen Receptor Beta (ERβ) Signaling in Neuronal Sytems
<p>With increasing life expectancy, women are now living upwards of 50 years without circulating estrogens, therefore, it is essential to investigate how the brain is changed by estrogen deprivation and also how aging influences these changes. The Women's Health Initiative (WHI) study spurred …
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Analyse molekularer Mechanismen der ERα- und ERβ-vermittelten Wirkung spezifischer Liganden und des Phytoestrogens Genistein
… Bedeutung der Estrogenrezeptorsubtypen ERα und ERβ bei der Gewebehomöostase in Knochen und Darm analysiert werden. Darüber hinaus sollten vor dem Hintergrund estrogenrezeptorsubtypspezifischer Wirkungsweisen gewebespezifische Einflüsse des Phytoestrogens Genistein (Gen) näher charakterisiert …
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Estrogen receptor beta modulates prostate carcinogenesis
… Most suggests that estrogen receptor beta (ERβ) is tumour-suppressive, but trials of ERβ-selective agents have not improved clinical outcomes. ERβ has also been implicated as an oncogene, therefore its role remains unclear. Additional evidence suggests interplay between ERβ and AR, the …
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An integrated network of estrogen receptors alpha and beta, and coregulators, for deciphering estrogen signaling in breast cancer cells
The nuclear hormone receptors, ERα and ERβ, are known to regulate the transcriptional response programs of their target cells, including breast cancer cells. However, their comparative abilities to localize at chromatin binding sites across the genome, and the recruitment of major coregulators such …
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Μελέτη της έκφρασης ορμονικών υποδοχέων στον πρωτοπαθή όγκο και στο λεμφαδένα φρουρό στο μελάνωμα και επιπτώσεις της στην έκβαση της νόσου
… η έκφραση των οιστρογονικών υποδοχέων (ERα και ERβ) σε όλες τις δυνατές περιπτώσεις. Η έκφραση του ERα ήταν εξαιρετικά ασθενής, αναδεικνύοντας τον ERβ σαν τον επικρατούντα οιστρογονικό υποδοχέα, τόσο στον πρωτοπαθή όγκο, όσο και στο λεμφαδένα φρουρό. H εντονότερη ανοσοέκφραση του ERβ …
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Étude de la régulation de l'expression de PAX-5 et de ses isoformes dans le cancer du sein: implication des récepteurs d'oestrogène ERα et ERβ 3
… women worldwide. Estrogen receptors ERα and ERβ are ligand-dependent transcriptional factors that mediate oestrogens biological effects, namely those of 17β-estradiol. They are expressed in the most cases of breast cancer and are well characterized for their role in the initiation and …
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Breast Cancer Progression and Phytoestrogen Interactions with Estrogen Receptors
… the ER focused on the wild type isoforms ERα and ERβ and different ligands (SWISS MODEL and docked through AutoDock Vina). Subsequently, isoforms of ERα and ERβ and different ligands (E1, E2, E3, PE, Tamoxifen, ICI 182,780) were modelled and tested by docking against the same set of ligands (E1, …
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The role of estradiol in astrocyte and neuron communication
… 3 showing that females and males express ERα and ERβ in CA1 Hipp astrocytes. Females expressed overall more ERs on astrocytes than males. Both females and males predominately expressed ERβ compared with ERα. I was also able to show that E2 increased calcium event frequency in males and females via …
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Dietary Soy Protein Isoflavonoid Effects on the Reproductive Tract of the Nonhuman Primate and Neoplastic Human Prostate Gland
… There are two ER receptor subtypes, ERα and ERβ. Both ER subtypes are expressed in the prostate gland. Estrogen receptor α is preferentially expressed in the stroma and ERβ is preferentially expressed in the epithelium. The effects of estrogen and estrogen-like compounds are mediated through …
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Der Effekt von Östradiol-17β und von Agonisten der Östrogenrezeptoren alpha und beta im Uterus und in der Vagina der ovarektomierten Ratte
… sowie der Kombination aus Östradiol und dem ERβ-Agonist an 3 Monate alten ovarektomierten Sprague-Dawley-Ratten. Die subkutane Verabreichung erfolgte für insgesamt vier Wochen in kontinuierlich simultaner und zeitversetzt zweiwöchiger, simultaner Kombination. Eine Östradiolgruppe diente als …
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Life Style, Molecular Pathology, and Breast Cancer Risk
… HER2 negativity, ERα+, PgR+, but negative ERβ expression. The enzyme HMG-CoA reductase was differentially expressed in breast cancer and high expression was associated with a smaller tumour size, low grade, low proliferation, and expression of ERα and ERβ, but not PgR. Estrogen-related …
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Folate - Associations with breast cancer depending on intake, metabolism, genetic variation and estrogen receptor status.
… consumers. Estrogen receptor β negative (ERβ-) breast cancer increased with higher plasma folate concentrations independently of 677C>T genotype. The results encourage consumption of folate rich foods. However, since women with disturbed folate metabolism due to genetic predisposition may …
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Localization and distribution of estrogen receptors and progesterone receptors in the bovine ovary in relation to the cell dynamics
… (ERα) en oestrogeenreceptor-β mRNA (ERβ mRNA) in de verschillende ovariële celtypes gedurende de oestrische cyclus van het rund. Deze cyclus werd ingedeeld in oestrus, metoestrus, vroege dioestrus, late dioestrus en prooestrus. De score voor ERα was laag in de ovariële follikels, de …
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Non-genomic control of neuronal calcium signaling by the steroid hormone estrogen leads to neuroprotective effects
… that estrogen deprivation caused an increase in ERβ and RyR2/3 colocalization, suggesting an interaction would be possible in living neuronal cells. Coimmunoprecipitation confirmed the existence of this interaction. Calcium mobilization experiments showed a correlation between the ERβ/RyR2/3 …
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Einflüsse von 17β-Östradiol, ER-subtypspezifischen Agonisten und Phytoöstrogenen auf inflammatorische Prozesse im Kolon
… 17β-Östradiol (E2) sowie selektive Liganden des ERβ sind antiinflammatorische Wirkungen im Darm bereits nachgewiesen worden. Diese Arbeit untersuchte in Modellsystemen für CED die antiinflammatorischen Eigenschaften von Isoflavonen, speziell von Genistein, und stellte einen Vergleich mit …
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Ethnic specific associations between body composition and metabolic risk and the role of sex hormones and aromatase among black and white South African women
… (SAT) expression of oestrogen receptors (ERα and ERβ) and aromatase (CYP19A), and body fat distribution and insulin resistance (IR) among black and white women (study 2).Methods: Study 1: In 288 black and 197 white premenopausal women, dual-energy X-ray absorptiometry (DXA) and computed tomography …
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Effects of Diethylstilbestrol on Murine Early Embryonic Stem Cell Differentiation Using an Embryoid Body Culture System
… proteins of interest: oct4, c-Kit, Flk1, ERα, ERβ, CD45, Flt1, & VE-cadherin. Analysis & Results: Changes in surface marker gene expression between day 0 and day 16 of differentiation were analyzed using the RT-PCR threshold counts (CT) and the comparative threshhold cycle method. The …
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Isolation and Characterization of Estrogen Receptor- Interacting Proteins
… complex, which interacts with ERα and ERβ both in unfractionated nuclear extracts and in purified form equally efficiently. Although some of other interacting proteins displayed subtype specificity, the main focus of the work was to characterize the function of TRAP/Mediator in …
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Evaluating Estrogen Receptor Signaling in Pancreatic β-Cells
… Expression of the estrogen receptor isoform, ERβ, increased ERE-dependent transcriptional activity and caspase 3/7 activity, however the magnitude of activation was less than ERα. Expanding these assays into human islets revealed that raloxifene treatment results in a significant increase in …
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Διερεύνηση μοριακών προγνωστικών παραγόντων στον καρκίνο του παχέος εντέρου
… σπάνια στο παχύ έντερο σε αντίθεση με τον ERβ, ο οποίος εκφράζεται συχνά στον πυρήνα επιθηλιακών αλλά και στρωματικών κυττάρων. Η έκφραση της πρωτεΐνης ERβ καθίσταται πιο έντονη κατά τη διάρκεια της καρκινογένεσης σε άνδρες, και στα αδενοκαρκινώματα συσχετίζεται με την πιθανότητα υποτροπής …
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