Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"EPOR"”.
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Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation
… production and signals through its receptor, the EpoR, on erythroid progenitor cells. Epo binding to EpoR activates Janus kinase 2 (JAK2), which phosphorylates cytoplasmic tyrosines of the EpoR. Signaling proteins bind these phosphotyrosines through SH2 domains, leading to the survival and …
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Genetic variants of EPO and EPOR influence cognitive core features of schizophrenia
… nach der Entdeckung von Epo und seinem Rezeptor (EpoR) im Gehirn hat es Jahre gedauert, bis mögliche direkte Effekte von Epo auf das Gehirn in in vivo Experimenten untersucht wurden. Eine große Anzahl präklinischer Studien folgte, die sich hauptsächlich mit dem Nutzen von Epo als neuroprotektives …
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Mechanisms of Erythroid Proliferation and Differentiation: Analysis of the Role of Erythropoietin Receptor in the Friend Virus Model
… role in this process by activating its receptor (EPOR) which is highly expressed in late erythroid progenitor cells. Although the molecular mechanisms of how EPOR signaling functions have not been entirely elucidated, evidence from genetic studies demonstrated its indispensable role for erythroid …
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Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer
… is mediated via binding to the EPO receptor (EPOR), which induces activation of different intracellular signaling pathways. Recombinant human EPO (rhEPO) is also used in treatment of cancer patients with anemia but some studies have reported negative effects on patient survival. Here we …
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Signal Transduction Effects Induced by Erythropoietin in a HNSCC Model System
… ectopically expressed erythropoietin receptor (EPOR) on the surface of cancer cells. The current study tests the biological effects of EPO and EPOR in HNSCC. A shRNA-mediated knockdown of the EPOR gene was applied to two specific cell lines, HN4 and its metastatic derivative HN12. Knockdown of …
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Μορφολογική μελέτη της έκφρασης των υποδοχέων κινάσης τυροσίνης Trks (υποδοχείς νευροτροφινών) και VEGFR-3 και συσχέτισή τους με την οδό μεταγωγής σήματος EpoR/ JAK-2/ STAT-5 στους όγκους εγκεφάλου του ανθρώπου
… (Epo) (μέσω δέσμευσής της με τον υποδοχέα της EpoR) η οποία πρόσφατα έχει θεωρηθεί ως παράγοντας-κλειδί της αύξησης των όγκων λόγω των αντιαποπτωτικών και αγγειογενετικών ιδιοτήτων και δυνητικός στόχος ογκολογικών θεραπευτικών στρατηγικών, δ) η Epo διαντιδρά με τον παράγοντα αγγειογένεσης VEGF …
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Molecular Mechanism of Parvovirus Infection
… of canines (MVC); 2) identifying the role of EpoR signaling in supporting B19V replication in erythroid of progenitor cells. To the first part, we take advantage of a recently developed in vitro permissive B19V infection system, and demonstrate that the small nonstructural protein 11kDa of …
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Rolle der Src-Kinasen in den Signaltransduktionswegen von Interleukin-6 und Erythropoetin
… werden und mit deren Rezeptoren, vor allem dem EpoR, assoziieren. Darüber hinaus scheint die Src-Kinase Lyn eine Rolle in der erythrozytären Differenzierung zu spielen.
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Expression and function of erythropoietin and its receptor in invertebrate nervous systems
… eines Erythropoietin/Erythropoietinrezeptor (EPO/EPOR) Signalsystems im Nervensystem von Invertebraten (Kapitel 2) und weist einen neuroprotektiven und neuroregenerativen Effekt von humanen EPO auf neuronale Zellen von Insekten in vivo (Kapitel 3) und in vitro (Kapitel 4) nach, die bisher nur im …
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Ein neuer und ungewöhnlicher Signalweg erlaubt physiologischen Konzentrationen von Erythropoetin mitogene Kinasen in primären erythroiden Vorläuferzellen zu aktivieren
… des zytoplasmatischen Endes des Epo-Rezeptors (EpoR), welche zum Verlust der Bindungsmöglichkeiten für verschiedene Signalproteine führt, anscheinend nur einen geringen Effekt auf das EpoR-Signalsystem hat. Diese Ergebnisse werden durch Viabilität und normaler Erythrozytenzahl von mutierten …
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Toward a Cell-Based Assay for Cubam-Mediated Intrinsic Factor-Vitamin B12 Binding and Uptake
… in the human digestive tract. Methods: A Cubam/EpoR chimeric receptor was expressed on the cell surface, which was expected to activate the JAK-STAT5 pathway and drive cell proliferation upon binding to the IF-Cbl complex. The main tasks included cloning and expressing human, bovine, and …
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Targeting Protein Degradation to Uncover Novel Oncoprotein Drivers of Acute Leukemia
… (CRBN) E3 ligase modulator, CC90009 was reported to show potent anti-tumor activity in acute myeloid leukemia (AML), leading to the identification of GSPT1 (G1 to S phase transition factor) as a CRBN neosubstrate. These findings suggest the potential of MGs to target unanticipated …
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A novel 4-valued discrete network for the analysis of signalling events integrating protein interaction and gene expression data applied on hematopoietic diefferentiation
… The analysis revealed central molecules of EpoR induced hematopoesis, like AKT, PIP3, Pi3K, Lyn, ERK.
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An in vivo study of novel genetic modifiers in autosomal recessive polycystic kidney disease (ARPKD)
… fibrosis and pulmonary hypoplasia, with death reported in around 30 – 50% of affected neonates. Mutations in PKHD1 and DZIP1L have been identified as causative genes for ARPKD, with the protein products of both genes localising to the primary cilium. Ciliary signalling pathways, such as Wnt …
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Protein-Protein Interactions and Small Molecule Targeting of the Multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 Ubiquitin Ligase
… receptor (GHR) and erythropoietin receptor (EpoR) were solved by X-ray crystallography with a goal to elucidate the SOCS2 recognition mechanism. Different interactions of the peptides were observed in the structures as a consequence of divergences in the peptide sequences, revealing residues …
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The role of erythropoietin in the pathophysiology of anemia associated with trypanosomiasis
… observations that link a genetic marker (Epo and EpoR polymorphism) to a phenotypic criterion (PCV) for trypanotolerance of cattle.