Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"EPO receptor"”.
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The role of erythropoietin in the pathophysiology of anemia associated with trypanosomiasis
… in sub-Saharan Africa. A blunted erythropoietin (Epo) response has been proposed as one possible mechanism that contributes to the nonresponsive anemia in trypanosome-infected cattle. The overall objective of this study was to examine the pathophysiologic role of Epo in the anemia associated with …
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Molecular and biochemical characterization of suppressor of cytokine signaling-3 (SOCS-3) and SH2-containing phosphatase 1 (SHP-1) in the context of G-CSF) and erythropoietin signaling
In this work interactions of SOCS-3 with the EpoR were studied since there was some evidence from the literature that SOCS-3 would bind to more than one recruitment site on the Epo receptor. For that purpose SOCS-3 was cloned, expressed and purified for subsequent biochemical studies. These …
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Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer
The main function of erythropoietin (EPO) is in hematopoiesis where EPO stimulates increased proliferation, survival and differentiation of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different …
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The impact of erythropoietin on uraemic cardiomyopathy
… contribute to heart failure. Erythropoietin (EPO) has evolutionised the treatment of the anaemia associated with CKD. The discovery that the EPO receptor is also expressed on cardiomyocytes highlights a role of EPO beyond haematopoiesis. However, little is known on the cellular impact of EPO …
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Expression and function of erythropoietin and its receptor in invertebrate nervous systems
… eines Erythropoietin/Erythropoietinrezeptor (EPO/EPOR) Signalsystems im Nervensystem von Invertebraten (Kapitel 2) und weist einen neuroprotektiven und neuroregenerativen Effekt von humanen EPO auf neuronale Zellen von Insekten in vivo (Kapitel 3) und in vitro (Kapitel 4) nach, die bisher nur …