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Showing 1 to 20 of 72 for “"EPO"”.
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Identification of Epo-independent red cell progenitors : the E-cad+ progenitors
… stem cell factor (SCF) und Erythropoietin (Epo) fällt dabei eine entscheidende Rolle zu. Unter ihrem synergistischen Einfluß lassen sich Epo-abhängige Zellpopulationen, die sich aus BFU-E und CFU-E Typ Zellen zusammensetzen, ausreichend amplifizieren (Panzenböck et al., 1998). Freyssinier et …
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Genetic variants of EPO and EPOR influence cognitive core features of schizophrenia
… Die positive Wirkung von Erythropoietin (Epo), ein hämatopoetischer Wachstumsfaktor, auf die kognitive Leistung ist bereits seit längerem bekannt, jedoch wurde dieser Effekt nahezu ebenso lang durch die Steigerung des Hämoglobinlevels erklärt. Selbst nach der Entdeckung von Epo und seinem …
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Systemic AAV-Mediated Gene Therapy Using Epo-R76E to Protect Retinal Ganglion Cells from Optic Nerve Injury and Disease
… of the underlying cause. Erythropoietin (EPO) exhibits neuroprotective effects in a variety of <em>in vitro</em> and <em>in vivo </em>models of neuronal cell death although its classical function is the regulation of red blood cell production. EPO crosses the blood brain barrier and …
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Tuberculosis, Anaemia and Erythropoietin: a study evaluating the role of erythropoietin in the pathophysiology of the anaemia of tuberculosis
… the advent of recombinant human erythropoietin (Epo ), it has become evident that a blunted Epo response to the anaemia plays a major role. The mechanism (s) involved still have to be elucidated. The aims of, this study were to evaluate serum Epo levels and iron parameters in anaemic patients …
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Ubiquitination of EpoR and p85 in Ligand Induced EpoR Down-Regulation
Erythropoietin (Epo) is the primary cytokine that drives red blood cell production and signals through its receptor, the EpoR, on erythroid progenitor cells. Epo binding to EpoR activates Janus kinase 2 (JAK2), which phosphorylates cytoplasmic tyrosines of the EpoR. Signaling proteins bind these …
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The role of erythropoietin in the pathophysiology of anemia associated with trypanosomiasis
… in sub-Saharan Africa. A blunted erythropoietin (Epo) response has been proposed as one possible mechanism that contributes to the nonresponsive anemia in trypanosome-infected cattle. The overall objective of this study was to examine the pathophysiologic role of Epo in the anemia associated with …
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Stage-Specific Multiomic Analysis of Human Erythroid Differentiation
… agents (ESAs), primarily erythropoietin (Epo) and its analogs, are major treatments for anemia, but often lead to organ damage and/or ESA resistance. Understanding the mechanisms of Epo-dependent erythroid differentiation is critical for identifying targets for the future development of …
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Erythropoietin Signaling in Pancreatic Beta Cells in Homeostasis and in Models of Type 1 and Type 2 Diabetes
… Evidence has suggested that erythropoietin (EPO) exerts cytoprotective effects on non-erythroid cells. However, the in vivo role of EPO on the pancreatic β cells has not been evaluated to date. We hypothesized that EPO would have direct cytoprotective effects on the pancreatic β cells and …
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Signal Transduction Effects Induced by Erythropoietin in a HNSCC Model System
… mature red blood cells (RBCs). Erythropoietin (EPO) is a systemically circulating hormone in the body that regulates the production of RBCs and is applied to treat anemia. Recently, several studies implicated shortened life expectancy of cancer patients by EPO administration. It may be due to an …
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Mechanisms of Erythropoietin-induced Neuroprotection in: in-vivo and in-vitro Models of hypoxia Ischema
… from bench to the bedside. Erythropoietin (EPO), a hematopoietic growth factor that increases oxygen availability during hypoxia/ischemia is associated with cell survival and neuroprotection in: in vivo and in vitro models of hypoxia ischemia. However these studies hold limited clinical …
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The impact of erythropoietin on uraemic cardiomyopathy
… contribute to heart failure. Erythropoietin (EPO) has evolutionised the treatment of the anaemia associated with CKD. The discovery that the EPO receptor is also expressed on cardiomyocytes highlights a role of EPO beyond haematopoiesis. However, little is known on the cellular impact of EPO …
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Studies on the specificities of <i>In Vivo</i> and <i>In Vitro</i> bioassays used in the potency determination of Therapeutic Erythropoietin
Erythropoietin (Epo), a kidney-produced cytokine, promotes the proliferation and differentiation of erythroid progenitors into mature red blood cells.<br></br><br></br>The <i>in vivo</i> biological activity of Epo is dependent on it being adequately glycosylated. Glycosylation is a variable process …
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Expression and function of erythropoietin and its receptor in invertebrate nervous systems
… eines Erythropoietin/Erythropoietinrezeptor (EPO/EPOR) Signalsystems im Nervensystem von Invertebraten (Kapitel 2) und weist einen neuroprotektiven und neuroregenerativen Effekt von humanen EPO auf neuronale Zellen von Insekten in vivo (Kapitel 3) und in vitro (Kapitel 4) nach, die bisher nur …
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Translational Aspects of Erythropoietin Receptor and Hypoxia-Inducible Factors in Breast Cancer
The main function of erythropoietin (EPO) is in hematopoiesis where EPO stimulates increased proliferation, survival and differentiation of erythrocytic precursors in response to hypoxia. The EPO effect is mediated via binding to the EPO receptor (EPOR), which induces activation of different …
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Ein neuer und ungewöhnlicher Signalweg erlaubt physiologischen Konzentrationen von Erythropoetin mitogene Kinasen in primären erythroiden Vorläuferzellen zu aktivieren
… Vorläuferzellen (PEPs) mit Erythropoetin (Epo) führt zur Aktivierung der mitogenen Kinasen („extracellular signal-regulated kinases“ (Erks) und „mitogen-activated protein kinase/Erk-activating kinases“ (MEKs)). Der Mechanismus der Aktivierung war bisher unklar. Mehrere wissenschaftliche …
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NOVEL APPROACHES TO MODELING AND TREATMENT OF COGNITIVE DEFICITS IN NEUROPSYCHIATRIC DISEASES
… Zweitens, der Effekt von Erythropoietin (EPO) auf die Verbesserung höherer kognitiver Funktionen (Lernen und Gedächtnis, Aufmerksamkeit und exekutiver Funktionen) bei Mäusen. Die Arbeit enthält ein Buchkapitel und drei Original-Erstautorpublikationen. Das Kapitel (El-Kordi et al., 2009) …
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Regulation of human 5-aminolevulinate synthase 2 expression during erythroid differentiation and its role in x-linked sideroblastic anaemia.
… transcription of ALAS2 during erythropoietin (Epo) stimulated erythroid differentiation. In order to investigate the regulation of ALAS2 transcription in the context of red blood cell maturation, an erythroid cell line, J2E, that terminally differentiates in response to Epo treatment was …
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Development and Evaluation of Ternary Amorphous Solid Dispersion of Poorly Water-soluble Compounds
… of polymer. From three different polymers (i.e., EPO, HPMCAS, and S100), the miscibility study indicated the best miscibility of CUR and RES with EPO. From the crystallization kinetics study, we inferred that EPO has a better crystallization inhibition effect than HPMCAS and S100. Finally, …
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Batch foaming of hot melt extruded excipient/disintegrant/API pharmaceutical formulations and the study of the effects of the resulting cellular structures on API dissolution
… (INM) is used as model API; Eudragit EPO (EPO) is used as polymer excipient; AcDiSol and Crospovidone (Cros) are used as two kinds of disintegrant. The main objectives are to gain an understanding of the resulting morphologies, as well as the impact of disintegrants on drug release …
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