Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"EPIC-Interact"”.
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Application of biomarker-based assessment of dietary patterns to nutritional epidemiology: observational and interventional investigations with a focus on the Mediterranean diet and type 2 diabetes
… dietary pattern. Chapter 3: I used the EPIC-InterAct case-cohort study which measured nutritional biomarkers at scale (~13,000 subcohort participants and ~9,000 incident type 2 diabetes cases) to evaluate the utility of combining them into biomarker scores predictive of adherence to …
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Investigation of Genetic and Behavioural Determinants of Type 2 diabetes and Glycaemic Traits
… in a large prospective cohort study for T2D, the EPIC-InterAct study. This work provides a valuable resource for the research community to conduct in-depth genetic investigations on T2D. The strongest T2D-associated genetic variant was at the established TCF7L2 locus. I then used the profiling of …
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The interplay between genes and dietary factors in the aetiology of Type 2 Diabetes Mellitus
… The aim of this PhD was to investigate gene-diet interactions on the risk of incident T2D, focusing primarily on macronutrient intake as the dietary factor. First, I systematically evaluated the current evidence before taking a step-wise approach (hypothesis driven to hypothesis-free) to …
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Beyond Parameter Estimation: Analysis of the Case-Cohort Design in Cox Models
… Further, these methods are applied to the InterAct dataset, and practical advice and sample code for STATA is presented. Estimation of Coefficients & Cumulative Baseline Hazard: For estimation of coefficients, Prentice weighting and Barlow weighting are the most commonly used (Sharp et al, …
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Meat consumption and type 2 diabetes: investigating heterogeneity and potential causal mechanisms
… intake) and the outcome (incident T2D) in the EPIC-Norfolk study, a population-based cohort study of over 25,000 participants. I worked on improving case ascertainment of T2D as the primary outcome in my analyses. I updated T2D case ascertainment in EPIC-Norfolk by linkage of multiple external …