Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"EPAC1"”.
-
EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
… EPAC is composed of two main isoforms, EPAC1 and EPAC2, whose roles in mediating cAMP effects in various cellular contexts remains relatively unclear, and must be elucidated to examine the therapeutic potential of these proteins. This work investigated the role of EPAC1 in promoting …
-
A Role For Epac1 and Epac2 In Nociceptor Hyperexcitability and Chronic Pain After Spinal Cord Injury
… contribution from each of its two main isoforms, EPAC1 and EPAC2, is unclear. Here I test the hypothesis that both EPAC1 and EPAC2 play a key role in the maintenance of persistent nociceptor hyperexcitability and chronic pain after SCI.</p> <p>Using both a T9 SCI mouse model and a T10 SCI rat …
-
Role of Exchange Protein Directly Activated by cAMP Isoform 1 in Energy Homeostasis
… has two isoforms, the ubiquitously expressed Epac1 and the more tissue restricted Epac2. The biological functions of Epac1 have been revealed, including cardiac stress, chronic pain, cancer and infections. However, the roles of Epac1 in energy balance are relatively unclear. To investigate the …
-
Role of Exchange Protein Directly Activated by cAMP Isoform 1 in Energy Homeostasis
… has two isoforms, the ubiquitously expressed Epac1 and the more tissue restricted Epac2. The biological functions of Epac1 have been revealed, including cardiac stress, chronic pain, cancer and infections. However, the roles of Epac1 in energy balance are relatively unclear. To investigate the …
-
Regulation of cAMP Signalling to Phospholemman by Phosphodiesterases
… energy transfer (FRET)-based cAMP sensor, PLM-Epac1-camps, was generated to enable direct monitoring of cAMP levels in the vicinity of PLM/NKA in ARVMs. Using fluorescence confocal microscopy, PLM-Epac1- camps was observed to be predominantly targeted to the perinuclear regions of the myocytes. …
-
Exploring the role of Leucine Rich Repeat Kinase 2 within the innate immune system
… reversal of the regulation of the expression of EPAC1, a cAMP inducible protein working in parallel with a previously described LRRK2 interacting protein PKA. EPAC1 acts, at least in part, via Ca2+ signalling. Modulation of signalling through pathways such as Ca2+, Wnt and cAMP appear as a theme …
-
Going With The Flow: Selective phosphodiesterase 4D7 (PDE4D7) regulation of vascular endothelial cell responses to fluid shear stress
… shown that exchange protein activated by cAMP (EPAC1) and cyclic nucleotide phosphodiesterase 4D (PDE4D) populate a multi-protein signalling complex along with VE- cadherin. These proteins function together to regulate VEC barrier function, cell morphology and gene expression of in response to …
-
Acidosis Activated GPR68 Promotes Vascular Smooth Muscle Cell Growth
… through cAMP and the downstream effectors EPAC1, Rap1A/1B, and ERK1/2. Activation of GPR68 under acidic conditions also shows possible influence on intracellular calcium and the cytokine IL-6. In comparison, our in vivo arterial injury studies that mimic acidic vascular conditions suggest a …
-
Investigation of the cAMP-mediated inhibitory mechanism on the signalling pathways of 2 cytokines: IL-6 and leptin in endothelial cells
… sensor; exchange protein activated by cAMP 1 (Epac1). Moreover, this inhibition was shown to be SOCS3-dependent. There also appeared to be a requirement for ERK1,2 activation in the cAMP-mediated inhibition of sIL-6R/IL-6-stimulated STAT3 activation in HUVECs. In contrast to these findings, …