Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"EP3"”.
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Prostaglandin EP3 receptor signalling as a contributor to sex differences in stress-related disorders mediated by the locus coeruleus
… signalling, particularly through the EP3 receptor expressed in LC neurons, has emerged as a key modulator of stress, nociception and affective behaviour, providing a mechanistic link between sex differences, stress regulation and chronic pain. The central hypothesis of this thesis is …
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Non-steriodal anti-inflammatory drug-mediated regulation of COX-2 and EP3 receptor expression in the M-1 murine cortical collecting duct cell line.
The cortical collecting duct (CCD) is a major site of intrarenal prostaglandin E2 (PGE2) synthesis. By indirect immunofluorescence using isoform specific antibodies, we have localized COX-1 and -2 immunoreactivity to all cell types of the murine M-1 CCD cell line. By, immunohistochemistry, both …
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PGE2 Receptor Subsets Mediate HCG Regulation of the Plasminogen Activator/Plasmin System in Primate Periovulatory Follicles
… <p>There are four PGE2 receptors: EP1, EP2, EP3 and EP4. To determine which PGE2 receptors are present in monkey periovulatory follicles, granulosa cells and whole ovaries were collected 0, 12, 24, and 36 hours after administration of an ovulatory dose of human chorionic gonadotropin (hCG), …
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Localization of Human Prostaglandin E2 Receptors in Polarized Epithelial Cells
… differ in their second messenger pathways. The EP3 receptor is unique in that it has eight different isoforms that differ in the lengths of the carboxyl tail. The EP3 isoforms, as well as the EP2 and EP4 receptors, have distinct properties, including different agonist-induced internalization …
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The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… all G-protein coupled receptors (GPCR). The EP3 receptor, the most abundant PGE2 receptor in the brain, is unique in that it is alternatively spliced giving rise to species specific isoforms. One of the EP3 receptor isoforms, EP3Re, is human specific and an incidental finding within a project …
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Cyclooxygenase-2 and prostaglandins in human endometrial function
… G protein coupled receptors namely EP1, EP2, EP3 and EP4. These receptors signal via alternate and sometimes opposing pathways. The initial aim of the research presented in this thesis was to investigate the temporal expression and signalling of the prostaglandin E2 pathway in the normal human …
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Regulation of Arachidonic Acid Pathway and Eosinophilic Inflammation in Chronic Rhinosinusitis/ Nasal Polyposis. Potential Role of Staphylococcus aureus Enterotoxins
… and nasal polyp subjects in contrast to EP1 and EP3, which were down regulated in the polyp group, suggesting a distinctive role of these receptors in the pathophysiology of nasal polyposis. Finally, based on our previous findings and parallel work of our group, we studied the influence of S. …
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Modulation der Insulinsignalgebung durch Prostaglandin E2 und Endocannabinoide
… werden, dass PGE2 in Rattenhepatozyten über den EP3 R ERK1/2-abhängig die intrazelluläre Weiterleitung des Insulinsignals hemmt. Über die Modulation der Insulinrezeptorsignalkette durch andere EP-Rezeptoren war bisher nichts bekannt. Daher sollte in stabil transfizierten Zelllinien, die jeweils …
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Binding and Signaling Differences between Prostaglandin E1 and E2 Mediated by Prostaglandin E Subtype Receptors
… four subtype receptors, designated as EP1, EP2, EP3 and EP4. Interestingly, PGE2 mediates inflammation whereas PGE1 acts as an anti-inflammatory factor. However, the molecular basis of their opposite actions on the same set of EP receptors is poorly understood. To study the ligand recognition …
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Alterações vasculares em ratos expostos ao diabetes materno: Contribuição das prostaglandinas derivadas da COX-2 e sua repercussão em diferentes idades
… o antagonista dos receptores EP1, EP2 e EP3 (AH 8809) e do receptor FP (AL8810). Em aorta dos ratos STZ12M, os valores percentuais de relaxamento e contração compatível com a observada na presença dos inibidores de COX somente foi alcançada quando pré-incubadas na presença do SQ29548 + …
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Characterization of signalling cross-talk between the EP2 and FP receptors in endometrial epithelial cells
… were not significantly altered while the EP3 subtype receptor was significantly down-regulated in fibroids compared to adjacent myometrium samples. The EP3 receptor has a protective role in tumor development suggesting the role for down-regulation of the receptor in uterine fibroids …
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Aplicación de un abordaje lipidómico para el estudio de la bioactividad in vitro de oxilipinas vegetales.
… como un posible receptor potencial al unirse a EP3. Los resultados obtenidos han esclarecido las propiedades antiiflamatorias y antioxidantes de FitoP y FitoF, sin embargo son necesarios más estudios in vitro e in vivo para arrojar luz sobre la capacidad funcional de las fracciones bioaccesibles …
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Identifizierung der für die Agonisten-induzierte Phosphorylierung und Internalisierung relevanten Serine und Threonine in der C-terminalen Domäne des humanen Prostaglandin E2 Rezeptors, Subtyp EP4
… intrazellulären InsP3/Ca2+-Spiegels, während der EP3-R an Gi-Proteine koppelt und die hormonstimulierte cAMP-Bildung hemmt. Der EP2- und der EP4-R sind an Gs gekoppelt und die Bindung von PGE2 an die Rezeptoren führt zur Erhöhung des intrazellulären cAMP-Spiegels. Die Sequenzidentität der vier …