Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"EP1"”.
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Fas ligand expression and tumour immune evasion; the role of prostaglandin E2 and the EP1 receptor
… through four different receptor subtypes, EP1 – EP4. Thus, the aim of this study was to investigate the effect of targeting the PGE2-FasL signaling pathway. Results: (i) PGE2 induces FasL expression via the EP1 receptor in colon cancer cells. (ii) Suppression of FasL expression in colon …
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The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
… signaling and other pathways. Two EP receptors, EP1 and EP4, were identified as the major isoforms in C2C12 cells. Blockage of either receptor significantly inhibited C2C12 myogenesis. Our results indicated that EP1 signaling is involved in regulating myogenin expression, while activation of EP4 …
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Binding and Signaling Differences between Prostaglandin E1 and E2 Mediated by Prostaglandin E Subtype Receptors
… of four subtype receptors, designated as EP1, EP2, EP3 and EP4. Interestingly, PGE2 mediates inflammation whereas PGE1 acts as an anti-inflammatory factor. However, the molecular basis of their opposite actions on the same set of EP receptors is poorly understood. To study the ligand …
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PGE2 Receptor Subsets Mediate HCG Regulation of the Plasminogen Activator/Plasmin System in Primate Periovulatory Follicles
… mediated.</p> <p>There are four PGE2 receptors: EP1, EP2, EP3 and EP4. To determine which PGE2 receptors are present in monkey periovulatory follicles, granulosa cells and whole ovaries were collected 0, 12, 24, and 36 hours after administration of an ovulatory dose of human chorionic …
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Modulation der Insulinsignalgebung durch Prostaglandin E2 und Endocannabinoide
… seine Wirkung über vier PGE2-Rezeptorsubtypen (EP1-EP4) vermitteln. In vorangegangenen Arbeiten konnte gezeigt werden, dass PGE2 in Rattenhepatozyten über den EP3 R ERK1/2-abhängig die intrazelluläre Weiterleitung des Insulinsignals hemmt. Über die Modulation der Insulinrezeptorsignalkette durch …
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Effect of Prostaglandin E2 on the Expression of Adhesion Molecules in Mouse Cerebrovascular Endothelial Cells
… binding to four G protein-coupled receptor (EP1-4). However, there have been contradictory reports on its actions in inflammation processes. For instance, PGE2 inhibits or stimulates ICAM-1 expression depending on the cell type and experimental conditions. Furthermore, the effect of PGE2 on …
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Charakterisierung von Prostanoidrezeptoren an Podozyten der Maus
… gezeigt werden, dass Podozyten mRNA für den EP1, EP4, FP, und TP Rezeptor exprimieren. Diese Daten zeigen eine mögliche Regulation spezifischer zellulärer Funktionen von Podozyten durch Prostaglandine und ihre jeweiligen Rezeptoren.
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Cyclooxygenase-2 and prostaglandins in human endometrial function
… via four G protein coupled receptors namely EP1, EP2, EP3 and EP4. These receptors signal via alternate and sometimes opposing pathways. The initial aim of the research presented in this thesis was to investigate the temporal expression and signalling of the prostaglandin E2 pathway in the …
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Das endogene Cannabinoid Anandamid erhöht Cyclooxygenase-2-abhängig den pulmonalarteriellen Druck in der isolierten Kaninchenlunge
… Anandamidwirkung. Jedoch konnte der spezifische EP1-Rezeptorantagonist SC 19220 den Effekt von Anandamid deutlich, jedoch nicht vollständig senken. Der Schluss liegt nahe, dass es sich bei den Anandamideffekten um FAAH und COX-2 abhängige Reaktionen handelt. Eine direkte oxidative Wirkung scheint …
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Regulation of Arachidonic Acid Pathway and Eosinophilic Inflammation in Chronic Rhinosinusitis/ Nasal Polyposis. Potential Role of Staphylococcus aureus Enterotoxins
… and nasal polyp subjects in contrast to EP1 and EP3, which were down regulated in the polyp group, suggesting a distinctive role of these receptors in the pathophysiology of nasal polyposis. Finally, based on our previous findings and parallel work of our group, we studied the influence …
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Prostaglandin-Mediated Reinstatement of Drug Taking After Alcohol Drinking by Female Adolescent Rats
… the interaction between PGE2 and its receptor 1 (EP1) also attenuated the increase in relapse drinking and restored alcohol drinking to the rate of alcohol naïve rats. Overall, these experiments identified a prostaglandin-mediated mechanism that is a putative target for the treatment of alcohol …
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Modulation of TGFβ1-induced Fibroblast-to-Myofibroblast Transition in response to Prostaglandin E2 Production by Human Rhinovirus-Infected Airway Epithelial Cells
… epithelial cells released PGE2 which acts via EP1-4 receptors on fibroblasts to suppress TGFβ1-induced α-SMA expression. Using an in vitro cell culture model, we confirmed HRV-infection of epithelial cells result in the upregulation of PGE2 and validated that PGE2 inhibits TGFβ1-induced α-SMA …
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Role of Prostaglandin E2 In The Regulation of Pancreatic Stellate Cells Hyper Activity Associated With Pancreatic Cancer
… Treating PSC with Specific antagonists against EP1, EP2 and EP4, demonstrated that blocking EP4 receptor only, resulted in a complete reduction of PGE2 mediated PSC activation. Furthermore, siRNA mediated silencing of EP4, but not other EP receptors, blocked the effects of PGE2 on PSC fibrogenic …
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Targeting Prostaglandin E2 Receptor EP2 for Treatment of High-Risk Neuroblastoma
… progression. However, the PGE2 receptor subtype (EP1-EP4) which potentially contributed to NB growth remained elusive. In this research, at first, we demonstrated that EP2 receptor was highly correlated with NB aggressiveness, and acted as a predominant Gαs-coupled receptor mediating …
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Alterações vasculares em ratos expostos ao diabetes materno: Contribuição das prostaglandinas derivadas da COX-2 e sua repercussão em diferentes idades
… TXA2 (furegrelato), o antagonista dos receptores EP1, EP2 e EP3 (AH 8809) e do receptor FP (AL8810). Em aorta dos ratos STZ12M, os valores percentuais de relaxamento e contração compatível com a observada na presença dos inibidores de COX somente foi alcançada quando pré-incubadas na presença do …
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The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… PGE2 signals via 4 E-prostanoid (EP) receptors, EP1-EP4, all G-protein coupled receptors (GPCR). The EP3 receptor, the most abundant PGE2 receptor in the brain, is unique in that it is alternatively spliced giving rise to species specific isoforms. One of the EP3 receptor isoforms, EP3Re, is …
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Identifizierung der für die Agonisten-induzierte Phosphorylierung und Internalisierung relevanten Serine und Threonine in der C-terminalen Domäne des humanen Prostaglandin E2 Rezeptors, Subtyp EP4
… Rezeptorsubtypen (EP-R) identifiziert. Der EP1-R ist an ein Gq-Protein gekoppelt und seine Aktivierung führt zu einer Erhöhung des intrazellulären InsP3/Ca2+-Spiegels, während der EP3-R an Gi-Proteine koppelt und die hormonstimulierte cAMP-Bildung hemmt. Der EP2- und der EP4-R sind an Gs …
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Regulation of Endogenous Excitatory Neurotransmitters by Isoprostanes
… the prostanoid receptor antagonists SC-19220 (EP1), AH-6809 (EP2/3), AH-23848 (EP4) or SQ-29548 (TP). SC-19220 (3 μM-30 μM), AH-6809 (3 μM-30 μM) and AH-23848 (3 μM-30 μM) reversed the inhibitory effects of 8-isoPGE2 on glutamate and glutamine levels in a concentration- dependent manner. As a …
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Transposon Tagging in Strawberry and Potato and Characterization of Representative Strawberry Mutants
… gene, epidermis-specific secreted glycoprotein EP1 precursor, was 670 fold higher in petioles of homozygotes than in wild type plants, suggesting the function of this gene involved in maintaining mechanical strength of petioles. Since the often-used transposase gene was cloned from the monocot …
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Characterization of signalling cross-talk between the EP2 and FP receptors in endometrial epithelial cells
… revealed that the expression of COX enzymes, EP1, EP2 and EP4 prostanoid receptors and prolactin were not significantly altered while the EP3 subtype receptor was significantly down-regulated in fibroids compared to adjacent myometrium samples. The EP3 receptor has a protective role in tumor …
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