Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"EP receptors"”.
-
The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
… through its G protein-coupled E prostanoid (EP) receptors is essential for skeletal muscle development or regeneration. Murine skeletal muscle cell line C2C12 was used as a model to test this hypothesis. The first part of the project is concerned with the role of PGE₂ in myogenic …
-
The molecular pathways mediating the role of cyclooxygenase enzymes and prostaglandins in cervical neoplasias
… its effects by interacting with one of four receptors termed EPI-4. Expression and signalling of EP receptors, including EP4, are elevated in cervical carcinomas. The initial aim of this study was to localise the site of expression of EP4 receptors in cervical squamous cell- and …
-
Localization of Human Prostaglandin E2 Receptors in Polarized Epithelial Cells
… mechanisms of protein sorting in polarized epithelial cells are poorly understood. Several studies have determined membrane targeting of G protein-coupled receptors (GPCRs) using epithelial cells such as Madin-Darby canine kidney (MDCK) cells. Polarized epithelial cells are composed of …
-
Role of Prostaglandin E2 In The Regulation of Pancreatic Stellate Cells Hyper Activity Associated With Pancreatic Cancer
… (MMP) genes. I further identified the PGE2 EP receptor responsible for mediating these effects on PSC. Using genetic and pharmacological approaches I identified the receptor required for PGE2 mediates PSC hyper activation. Treating PSC with Specific antagonists against EP1, EP2 and EP4, …
-
The Prostaglandin E2 Receptor Subtype 3E and its involvement in tauopathies
… of Alzheimer’s disease and tauopthies. Epidemiological studies report a delay in the onset of Alzheimer’s in subjects using nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs inhibit enzymes in the cyclooxygenase-2 (COX-2) pathway which play a key role in synthesising prostaglandin E2 …
-
Binding and Signaling Differences between Prostaglandin E1 and E2 Mediated by Prostaglandin E Subtype Receptors
… (PGE2) are ligands for the prostaglandin E2 receptor (EP) family, which consists of four subtype receptors, designated as EP1, EP2, EP3 and EP4. Interestingly, PGE2 mediates inflammation whereas PGE1 acts as an anti-inflammatory factor. However, the molecular basis of their opposite actions on …