Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 145 for “"ENT"”.
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ENT Educational Patient Bedside Tool
… discharge preparations are an advantage to patients, the interdisciplinary team, and hospital. It was determined that lack in communication and coordination among staff members led to inadequate patient teaching, therefore an educational tool that is kept at the bedside may facilitate …
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Chemoenzymatic Synthesis of ent-Neopinone
The present thesis describes the chemoenzymatic synthesis of ent-neopinone. The total synthesis of neopinone was accomplished in 14 steps from B-bromoethylbenzene. The synthesis began with a microbial oxidation of bromobenzene by Escherichia coli JM109(pDTG601) and features a Heck reaction, aldol …
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Enzymic Oxidations of Ent-Kaurene and Ent-Kaurenol in Gibberellic Acid Biosynthesis: Stereochemistry and Isotope Effects
… oxidase (MFO) catalyzed C19 hydroxylations of ent-kaur-16-ene (1) and of ent-kaur-16-en-19-ol (2) precede a complex cascade of enzyme catalyzed reactions leading to the plant growth regulator gibberellic acid. The stereochemistry and deuterium isotope effects (k(,H)/k(,D)) of these two …
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The progress towards the total synthesis of (ent)-MPC1001
… are my efforts toward the total synthesis of (ent)-MPC1001, beginning with the development of a novel asymmetric [1-3]-dipolar cycloaddition utilizing a vinyl silane and a chiral lactone template. The mechanism of the cycloaddition was investigated and the cyclized product can be elaborated in …
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The Stereochemistry and Mechanism of The Biosynthesis of Ent-Sandaracopimaradiene and Related Diterpenes
The stereochemistry and mechanism of the cyclization of copalyl pyrophosphate to (+)-sandaracopimaradiene by enzyme extracts from R. cummunis was investigated. (S)-Geranyl-geraniol-1-d was prepared by enzymatic reduction of geranyl-geranial-1-d with horse liver alcohol dehydrogenase and NAD('+) …
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Total synthesis of ent-plagiochianin B and development of a metathesis approach to aleutianamine.
… 6/7/3 tricyclic core. The total synthesis of ent-plagiochianin B was achieved in 9 synthetic steps from a known cycloheptenone and 13 steps overall starting from (+)-3-carene. As anticipated, the inherent stereochemistry found in (+)-3-carene led to production of material that was enantiomeric …
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Nickel-catalyzed coupling reactions and synthetic studies toward ent-dioxepandehydrothyrsiferol via an epoxide-opening cascade
… coupling and alkene--aldehyde coupling represent two methods of preparing allylic alcohols. Most asymmetric transition metal-catalyzed methods of preparing enantiomerically enriched allylic alcohols rely on chiral ligands. The nickel-catalyzed allene--aldehyde coupling exploits the axial …
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Bromonium-Initiated Epoxide-Opening Cascades : total Synthesis of ent-Dioxepandehydrothyrsiferol and Synthetic Studies toward (+)-Scholarisine A
… Epoxide-Opening Cascades: Total Synthesis of ent-Dioxepandehydrothyrsiferol Our foray into the total synthesis of ent-dioxepandehydrothyrsiferol has led to the discovery and development of the bromonium-initiated epoxide-opening cascade. This transformation constructs the signature …
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Siderophore-Based Drug Repurposing of Platinum Anticancer Agents as Targeted Antibiotics and Investigation of Pt-Induced DNA Damage in Gram-Negative Bacteria
… antibiotics disrupts the human microbiota, potentially leading to the onset of diseases associated with microbial dysbiosis. Consequently, there is an urgent need for innovative strategies to develop narrow-spectrum antibiotics. One promising approach involves the development of …
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Asymmetrische Synthese von 1-Aminocyclobutancarbonsäuren
… Hydroxy-2,3,3-trimethyl-butansäure (4) sowie die Entwicklung einer effizienten Razematspaltung dieser Säure. Nach dem Aufbau des Glycinäquivalents sollte dieses für den stereoselektiven Aufbau 2-substituierter 1-Aminocyclobutancarbonsäuren verwendet werden. Dabei sollte zum einen auf bereits …
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Development of Remote Sensing Assisted Water Quality Nowcasting and Forecasting Models for Coastal Beaches
… Program-based model for predicting early morning enterococci (ENT) levels in beach waters; (2) an ANN model (Model 2) and an VB model for predicting early morning Fecal Coliform (FC) levels in beach waters; (3) a remote sensing assisted modeling system (Model 3) for predicting near real time ENT …
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Integration of class 1 HDAC inhibitors into current treatments for prostate cancer
… Although highly effective, relapse to recurrent disease occurs in 20-50% of men and resistance to subsequent hormonal therapies results in progression to incurable castrate resistant prostate cancer (CRPC). Androgen signalling inhibitors (ASI), including Enzalutamide (ENZ) and Abiraterone …
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Cargo delivery into gram-negative bacteria via enterobactin uptake machinery
… Iron Homeostasis and Siderophores Iron is an essential nutrient for almost all living organisms. This Chapter presents an overview of iron homeostasis in human and bacteria, as well as the biology and chemistry of siderophores and siderophore conjugates. Siderophores are small-molecule iron …
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Metrics for Evaluating Surgical Microscope Usage During Myringotomy
… surgical microscope manoeuvring is a fundamental step in middle ear surgical training, currently there is no objective method to teach or assess this skill. This thesis presents an experimental study designed to implement and test sets of metrics capable of numerically evaluating microscope …
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Pembangunan kerangka konsep modal insan holistik berciri keusahawanan
… usaha telah dilaksanakan oleh pihak berkepentingan menerusi lonjakan pertama Pelan Pembangunan Pendidikan Malaysia 2015-2025 (Pendidikan Tinggi), (PPPM-PT) serta kelangsungan daripada perlaksanaan Pelan Tindakan Keusahawanan Institusi Pengajian Tinggi 2016-2020, pembangunan modal insan yang …
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Modelling Cell Orientation In Artificial Tissues
Engineered tissues have many potential applications both as experimental systems and in therapeutic devices and treatments. Specially, there is potential to repair damaged spinal cord, however work is still needed to predict the process of tissue growth. Computational physics has potential to …
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The doctor-patient relationship: an exploration of trainee doctors’ views
… which medical trainees perceive the doctor-patient relationship could inform future developments in educational provision. A qualitative study was conducted, using a case study approach to explore the perceptions of postgraduate trainees in two medical specialties, general practice (GP) and …
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