Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 280 for “"EMT"”.
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Deciphering AXL-Driven Molecular Mechanisms of EMT
Pages xviii-xix are misnumbered as pages xix-xx.
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ING1 Impacts Ovarian Cancer by Altering EMT
… the epithelial-mesenchymal transition (EMT) program that suppresses cancer metastasis and identifies the mechanism of how ING1 regulates gene transcription, as well as its clinical implication in epithelial ovarian cancer. Our analyses revealed that ING1 epigenetically regulates the …
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Improving rational modeling realization for accurate EMT simulations
… often neglected in electromagnetic transient (EMT) analyses, known as Frequency Warping. This thesis establishes the frequency warping as a fundamental problem that compromises the accuracy of EMT simulations, requiring specific approaches for its mitigation. Initially, the manifestation of …
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Trim24 Orchestrates Metabolic Reprogramming and Emt In Breast Cancer
… and epithelial mesenchymal transition (EMT) in breast cancer. TRIM24 was first established by our laboratory as a previously unknown negative regulator of p53 via its RING domain, as a co-regulator of nuclear receptors and a PHD/Bromodomain reader of specific histone modifications. …
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The role of microvesicles in EMT and tumour microenvironment
… involved in Epithelial Mesenchymal Transition (EMT) process. PNT2 cells acquire mesenchymal characteristic produced high level of resistances against apoptotic signals after exposed to serum starvation and anti-cancer drug docetaxel, produce excessive level of MMP-9 and 2/3 of total TPNT2 cell …
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Post-Translational Regulation of Zeb1 Contributes to Tgfβ-Mediated Emt
… targets. Epithelial-to-mesenchymal transition (EMT) is a proposed model for the initiation of metastasis. During EMT epithelial cells lose their cell adhesion properties and acquire a mesenchymal-like phenotype, allowing tumor cells to migrate from their epithelial cell community and invade …
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FROM MICRONUCLEI TO EMT: MOLECULAR MECHANISMS OF GENOMIC INSTABILITY AND CELLULAR PLASTICITY
… instability, autophagic pathways, and EMT, providing insights into the mechanisms that drive tumorigenesis and metastasis.
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Use of global datasets for downscaling soil moisture with the EMT+VS model
… Moisture from Topography, Vegetation, and Soil (EMT+VS) model downscales soil moisture using fine-resolution topography, vegetation, and soil data. It has been shown to reproduce temporally unstable soil moisture patterns (i.e. patterns where the spatial structure varies in time). It can also …
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The Role of The Epithelial-To-Mesenchymal Transition (Emt) In Lung Cancer Progression
… undergo an epithelial-to-mesenchymal transition (EMT) that is regulated by a double-negative feedback loop between the transcription factor Zeb1 and the microRNA-200 family (miR-200). Furthermore, these studies demonstrated that mesenchymal lung cancer cell invasion and metastasis are dependent on …
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Inhibition of pancreatic cancer progression through EMT inhibition and induction of ER stress
… cell epithelial to mesenchymal transition (EMT) contributes importantly to cell invasion, metastasis, and drug resistance in pancreatic cancer. In addition, pancreatic cancer cells exhibit an elevated basal level of unfolded protein response (UPR) signaling for survival, due to increased …
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Investigating Novel Inhibitors of Epithelial - Mesenchymal Transition (EMT) and Cancer Stem Cells (CSCs) in Pancreatic Cancer
… cancer cell epithelial-mesenchymal transition (EMT), which contributes to the plasticity of cancer cells and comprises an initial step for metastasis. Inhibiting EMT and CSCs in pancreatic cancer could potentially inhibit pancreatic cancer progression, metastasis, and drug resistance. Various …
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Snail1-mediated Gene Repression Links EMT to Enhanced Biliary Epithelial Cell Survival and Lung Epithelial Cancer Cell Migration
… mechanisms. Epithelial-mesenchymal-transition (EMT) is a naturally occurring and strictly regulated trans-differentiation process essential for tissue morphogenesis during early embryonic development. Recent studies suggest that aberrant reactivation of EMT in adults may be a key event in both …
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The role of seminal fluid in cervical squamous carcinoma progression: Impact on cell proliferation, EMT, motility and gene expression
… the effect of SF on cancer cell proliferation, EMT, motility and gene expression using two squamous cell carcinoma cell line model systems, SiHa and Me180. This study shows that SF significantly enhanced cell proliferation in both cell lines. Using confocal microscopy and phalloidin staining, it …
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Investigation of Genetic Alterations In Emt Suppressor, Dear1, Through Pan-Cancer Analysis and Ultra-Deep Targeted Sequencing In Ductal Carcinoma In Situ
… TGFβ-driven epithelial-mesenchymal transition (EMT)<sup>1</sup><sup>,</sup><sup>2</sup>. Herein, I have shown by pan-cancer database analysis that chromosomal loss of <em>DEAR1</em> is a moderately frequent event in multiple epithelial cancers and that targeted deletion of <em>Dear1</em> in the …
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Characterising human lung tissue for biomarkers of EMT-fibrosis and functional steroid receptor components in chronic obstructive pulmonary disease (COPD) patients and control subjects
… fibrotic Epithelial to Mesenchymal Transition (EMT) have been identified in heart and kidney disorders and we wished to evaluate if this is a contributing factor in COPD. Second, patient treatment options are limited. Steroid resistance is the major barrier for effective treatment and this study …
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ZEB1 is a central mediator of the Epithelial-Mesenchymal Transition
… tumor. The Epithelial-Mesenchymal Transition (EMT) provides a model by which tightly associated epithelial cancer cells can disseminate to distant sites. Many factors are known to trigger the EMT, but the extent to which the observed phenotypes represent a common process is unknown. There is …
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The transcription factor grainyhead-like 2 is a novel suppressor of the epithelial to mesenchymal transition
The epithelial to mesenchymal transition (EMT) is a process that is essential for normal embryonic development as well as the healing of damaged adult tissues. In the context of cancer, oncogenic EMT induces enhanced invasion, survival and tumorigenicity which can promote disease progression and …
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Metabolic reprogramming associated with the epithelial-mesenchymal transition in pancreatic cancer
… by the epithelial-mesenchymal transition (EMT). While the role of Warburg metabolism has been recognised in supporting rapid cellular growth and proliferation in many cancer types, less is known about the metabolic changes occurring during EMT, particularly in the context of pancreatic …
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A Naturalistic Inquiry into the Experiences of Emergency Medical Technicians and Paramedics Who Become Registered Nurses
… is Emergency Medical Technicians and Paramedics (EMT-P). EMT-Ps can bring important skills and knowledge to nursing. Concern about attrition of EMT-Ps from pre-licensure nursing programs and the dearth of literature about EMT-Ps who are interested in becoming registered nurses led to this …
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