Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"EMCV"”.
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Investigating the functional roles of the viral frameshift protein 2B* in EMCV infection
Encephalomyocarditis virus (EMCV) is capable of infecting a wide range of mammalian hosts, causing encephalitis, diabetes, myocarditis in mice and primates as well as reproductive disorders in pigs. The severe pathogenicity is considered to be a result of the rapid cell lysis caused by EMCV. This …
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Sensing of Picornavirus Infections
… mice we showed that encephalomyocarditis virus (EMCV) and coxsackievirus B3 (CVB3), picornaviruses of the cardiovirus and the enterovirus genus respectively, are sensed by both MDA-5 and RIG-I. Sensing of these viruses in macrophages leads to the expression of type I IFN early after infection …
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Role of Hypoxia-inducible Factor in Kidney Cancer
… cells. We also demonstrate that the picornavirus EMCV (Encephalomyocarditis virus) efficiently destroys ccRCC tumour cells in an NF-kappaB- and HIFalpha-dependent manner both in vitro and in a mouse xenograft model. This work provides pre-clinical evidence for the potential use of EMCV in an …
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The Role of MDA5 and TLR3 in Response to dsRNA and Viral Infection
… norovirus: MNV) and encephalomyocarditis virus: EMCV), we demonstrate that both MDA5 and TLR3 limit viral replication. Neither MDA5-/- nor TLR3-/- animals controlled MNV and EMCV infection as well as wild type: WT) controls, but DKO mice were more susceptible to infection than either single …
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Biochemische Charakterisierung und physiologische Bedeutung eines neuen durch Typ I Interferon induzierten Gens
… einer Infektion mit Encephalomyocarditis-Virus (EMCV) und Vesicular-Stomatitis-Virus (VSV) hinauszögert. Dieser Nachweis konnte an zwei verschiedenen Zelllinien erbracht werden, womit sichergestellt ist, dass die antivirale Aktivität kein Positionseffekt der integrierten DNA darstellt. Um den …
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Defining the Physiological and Molecular Role of Pellino3 in TLR3 Signalling
… and lethal effects of encephalomycarditis virus (EMCV) infection. Pellino3 functions in a novel auto-regulatory mechanism to specifically prevent excessive TLR3 induced expression of type 1 IFNs but leaves pro-inflammatory cytokine production intact. TLR3 signalling induces Pellino3 expression …
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Untersuchung der Typ I Interferon-Signaltransduktion in HPV-Onkogen immortalisierten Keratinozyten
… der Indikatorviren Encephalo-Myocarditis-Virus (EMCV) und Vesikulo-Stomatitis-Virus (VSV) konnte die biologische Aktivität der konstitutiv exprimierten Interferone gezeigt und ein Zusammenhang zwischen mangelnder IFN--Expression und Verlust der Protektion gegenüber VSV erklärt werden. Dieser …
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Investigations into the role of RNA modification in the function of the c-Myc IRES
… including c-Myc, Bag1, MNT, Apaf-1, HCV and EMCV.
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Identification and Characterization of Auxiliary Factors in Innate Antiviral Immunity
… I IFN response by encephalomyocarditis virus (EMCV) via MDA5 signaling, but it was dispensable for antiviral gene expression in response to Sendai virus infection, which engages and activates the RIG-I-dependent pathway. Loss of OASL specifically reduced MDA5 signaling and enhanced virus …
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Vectores de expresión de cDNAs genómicos de Rabbit vesivirus (RaV) y análisis de su funcionalidad como clones infectivos
… Se generó un vector que contiene el IRES de EMCV precediendo al genoma para investigar su acción potenciadora de la traducción y el efecto de ésta sobre el rescate de virus. Por otra parte se construyeron vectores de expresión del genoma controlados por el promotor fuerte de CMV, que se …