Global ETD Search
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Showing 1 to 8 of 8 for “"EIII"”.
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Generation and Characterization of Flavivirus Receptor-Binding Domain Mutants and Chimeras
… domain of the envelope glycoprotein, domain III (EIII). In order to determine the tolerance for heterologous sequences, and to characterize the role of EIII in virus growth and tissue tropism, chimeric viruses were generated using the West Nile virus (WNV) infectious clone, into which EIIIs from a …
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Investigating the role of the West Nile virus and Koutango virus envelope protein in virulence phenotypes using structural protein chimeras
… envelope protein domain III chimera (WNV/KOUV-EIII), which was generated from the combination of two highly virulent viruses. It was hypothesized that attenuation was due to intra- and/or inter-molecular interactions between the WNV E protein domains important for efficient viral replication …
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Phenotypic Characterization of Mutations Made to the Envelope Protein of West Nile Virus
… major component of the virion surface, with the EIII being the putative receptor binding domain. Previous studies showed that Gly to Ala mutation of EIII residue 331 (G331A) yielded a virus that had altered antigenicity, slightly restricted growth in Vero cells, and a highly attenuated phenotype …
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Estratigrafía y evolución magmática del Grupo Los Menucos (Triásico), provincia de Río Negro, Argentina
… permitieron reconocer tres eventos – EI, EII, EIII – relacionados a la evolución crustal del Macizo Nordpatagónico. El primer evento EI fue subdividido en dos ciclos menores, C1 y C2. El C1 ligado al Pérmico Tardío indica la generación de magmas derivados de una corteza antigua …
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Impact of West Nile Virus Envelope Domain III Surface Loop Residues on Antigenicity and Virulence
… residues in the function and antigenicty of WNV EIII, a panel of mutants was generated. Changes in antibody neutralization, in vitro replication kinetics, and in vivo virulence were characterized. In general, it was found that diversity in the surface loops was well tolerated and that all surface …
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Impact of West Nile Virus Envelope Domain III Surface Loop Residues on Antigenicity and Virulence
… residues in the function and antigenicty of WNV EIII, a panel of mutants was generated. Changes in antibody neutralization, in vitro replication kinetics, and in vivo virulence were characterized. In general, it was found that diversity in the surface loops was well tolerated and that all surface …
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Promoters and Heterogeneous 5' Termini of the Messenger RNAs of Adenovirus 2
… sites including EIa, EIb, PIX, major late, EIII, EIV and the late form of region IIa mRNA have clearly defined TATA box homologies. With early region IIa and IVa2, this homology is absent. For most messengers, the mRNA terminus is microheterogeneous, and encoded within a 2-7 base cap site …
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Das Intrathorakale EKG im implantierbaren Cardioverter/Defibrillator : Erweiterung der EKG-Diagnostik in implantierbaren Systemen
… mit differenter Elektrode in RVA (EII, EIII, Gi) zeigten dabei höhere Amplituden (p < 0,0001). Die QRS-Dauer korrelierte eng (r = 0,863; p < 0,0001) zwischen IEKG (124 ± 25 ms) und SEKG (125 ± 25 ms). Die Amplitude und Dauer des lokalen ventrikulären Elektrogramms betrug 11,16 ± 4,02 mV …