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Showing 1 to 20 of 41 for “"EIF4E"”.
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Assessing eIF4E-S209 Signaling and Translationally Regulated Mechanisms in Neurodegeneration
… eukaryotic translation initiation factor 4E (eIF4E). Downstream of stimuli, ERK or p38 can phosphorylate the MAPK interacting serine/threonine kinases (MNKs) 1 and 2. MNK1 or 2 then phosphorylate eIF4E, at a specific residue; serine 209 (S209). Phosphorylation of eIF4E-S209 by the MNKs can …
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eIF4E Phosphorylation Balances Cap-dependent and Cap-independent Translation Initiation
… initiation through the cap-binding protein eIF4E. </p><p>Aberrant regulation of eIF4E has important roles in several pathologies and, most notably, in tumorigenesis. Nevertheless, the understanding of the molecular con-sequences of changes in eIF4E activity remains incomplete. We employ a …
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The role of eukaryotic initiation factor 4E (eIF4E) in osteosarcoma metastasis
… phosphoprotein, eukaryotic initiation factor 4E (eIF4E) is considered to be both rate and process limiting. We describe for the first time, the biological role of eIF4E (new biology) in metastatic osteosarcoma. We employed a comparative approach to study the biology of metastasis in osteosarcoma …
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CHARACTERIZATION OF THE EUKARYOTIC TRANSLATION INITIATION FACTOR 4E (eIF4E) FAMILY MEMBERS IN THE ZEBRAFISH (Danio rerio)
The present study examines the six eIF4E cognates in zebrafish. In addition to the prototypical translation initiation factor eIF4E, eukaryotes have evolved eIF4E variants with distinct characteristics, some of which negatively regulate the recruitment of specific mRNAs. Metazoan eIF4E family …
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Role of Ribavirin, an Anti-Viral Agent, In Eukaryotic Initiation Factor 4e (Eif4e) Subcellular Localization and Function
Expression of eukaryotic initiation factor 4E (eIF4E) is necessary for active cellular growth and catalysis of the rate-limiting step in cap-dependent protein synthesis3-5. Studies in the past decade have shown that eIF4E contributes to malignancy by selectively facilitating the translation of a …
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Point mutational examination of eukaryotic initiation factor 4E (eIF4E), inclusion bodies analysis, and Barley Yellow Dwarf Virus (BYDV) exonuclease resistant RNA structure mapping and prediction
<p>Eukaryotic initiation factor 4E (eIF4E) binds the 5’m7GTP cap structure of mRNA in order to facilitate effective translation. Recessive eIF4E alleles harboring naturally occurring point mutations have been associated with resistance to viral infection, particularly in members of the genus …
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Pyp3 Involvement in Mitotic Control and Cell Growth in Fission Yeast
… of the positive interacting proteins is tif1. eIF4E (Tif1) is the mRNA cap-binding protein and essential for recruitment of ribosomes to mRNA. Our results show that Pyp3 physically interacts with eIF4E in vivo and affects both the phosphorylation state and cellular distribution of eIF4E. In …
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Identificação de parceiros funcionais e propriedades do fator EIF4E5, homólogo do fator de iniciação da tradução EIF4E (EIF4E5) de Leishmania infantum
… destaca-se o complexo eIF4F, onde a subunidade eIF4E é a responsável pelo reconhecimento dos mRNAs por meio de sua extremidade 5 Nos tripanossomatídeos, protozoários parasitas de importância médica, sua expressão gênica é regulada pós-transcricionalmente e durante a tradução. Nesse contexto, …
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Identificação dos genes eIF4E e eIF(iso)4E em Solanum habrochaites f. glabratum e introgressão do alelo de resistência ao PepYMV(Pepper yellow mosaic virus)em tomateiro
… no fator de iniciação da tradução eucarióticos eIF4E e eIF(iso)4E, que levam à resistência recessiva ao vírus, por meio da redução ou mesmo da ausência da multiplicação viral. Os objetivos deste trabalho foram: i) identificar os alelos eIF4E e eIF(iso)4E encontrados no acesso de tomate silvestre …
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Elucidating the Roles of Eukaryotic Initiation Factors Involved in DAP5 Mediated Translation
… which consists of the cap binding protein eIF4E, the scaffolding protein eIF4GI, and the helicase factor eIF4A.The recognition and binding of eIF4E to the m<sup>7</sup>G cap structure of the mRNA is essential for the subsequent recruitment of eIF4GI and eIF4A to form a translationally …
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Norovirus Translation and Replication
… as a surrogate system to understand the role of eIF4E phosphorylation in norovirus pathogenesis, and VP1-RdRp interaction in regulating viral genome replication. MNV infection results in the phosphorylation of the translation initiation factor eIF4E, re-programming host-cell translation during …
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The Interaction Between Eukaryotic Translation Initiation Factor eIF4G and 3’ Cap Independent Translation Element of Barley Yellow Dwarf Virus Is Affected by Multiple Initiation Factors
… from 601 to 1196, including binding domains for eIF4E, central eIF4A, eIF4B and the possible BTE binding region; eIF4G601-1488 is a longer fragment with one additional C-terminal eIF4A binding domain; eIF4G742-1196 is a shorter deletion mutant lacking the eIF4E binding sequence. eIF4G601-1196 …
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The Dietary Isoprenoid Perillyl Alcohol Inhibits Telomerase Activity in Prostate Cancer Cells
… <p>Prostate cancer cells overexpress eIF4E (eukaryotic initiation factor 4E) the rate-limiting protein that mediates cap-dependent translation by way of mTOR signaling. Immortalized Chinese hamster ovary (CHO) control cells (pMV7) and CHO cells with forced eIF4E-overexpression (rb4E) …
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A molecular genetic analysis of resistance to poleroviruses in sugar beet and oilseed rape
… the Arabidopsis elongation initiation factor 4E (eIF4E) gene which has already been implicated in susceptibility to other viruses. This gene has frequently been shown to be important for viral infection in plants, and naturally occurring mutations can result in resistance to other viruses. Further …
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Development of chemical probes for intracellular nucleotide delivery, profiling of the metabolic fate(s) of nucleoside monoester phosphoramidates, and a nucleotide mimetic inhibitor of eIF4E
… development of a nucleotide mimetic inhibitor of eIF4E in Chapter 5. As a proof-of-concept application, we employed a sulfamido alkyl moiety as a substitute for 5´-phosphate in the design of 5´-mRNA cap analog antagonists of eIF4E. We successfully synthesized a mimetic of 7-Chlorophenoxyethyl …
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The Effect of Post Exercise Nutrition on Anabolic Response to Resistance Exercise
… resistance exercise bout increased the amount of eIF4E-eIF4G by 4.5% 1-hr postexercise (p<0.05) without affecting the amount of eIF4E-4E-BP1. One hour after beverage consumption, serum total amino acid concentration increased for MILK 1 (p=0.003) and MILK 2 (p<0.001) but decreased for CE (p=0.028) …
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Role of 4E-BP2 in neuronal translation
… plasticity, learning and memory. 4E-BP2 (Eif4ebp2, Eukaryotic Initiation Factor 4E-Binding Protein 2) is the predominantly expressed 4E-BP in the mammalian brain and represses cap-dependent translation initiation, by binding to eIF4E (Eif4e, eukaryotic Initiation Factor 4E). As a master …
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Identification and stoichiometric analysis of the monosomal translational complex
… and components of the closed-loop structure, eIF4E, eIF4G1/eIF4G2 and PAB1. The abundance of 77S complexes decreased with translational defects and following the stresses that cause translational stoppage. By quantitating the abundance of the 77S complex in response to different stress …
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Regulation of Mnk1 by p38α MAPK in Stress Mediated Translation Initiation
… relays signals to its major downstream target eIF4E. Activation of Mnk1 and subsequent phosphorylation of eIF4E results in changes in translation rates for subsets of mRNAs. Both the Erk1/2 and p38 MAPK pathways activate Mnk1 meaning that Mnk1 responds to growth signals through Erk1/2 and …
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