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Showing 1 to 20 of 41 for “"EHEC"”.
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Studies of EHEC and the complement system in renal diseases
… caused by Enterohemorrhagic Escherichia coli (EHEC) or with complement dysfunction due to complement mutations or auto-antibodies (atypical HUS, aHUS). EHEC is a non-invasive highly virulent bacterium. In order to gain access to the circulation it first damages the intestinal mucosa. The …
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The Functional Characterization of the Quorum Sensing E. Coli Regulators B and C in EHEC
Enterohemorrhagic E. coli (EHEC) is the causative agent of hemorrhagic colitis. During an infection, EHEC can sense and respond to environmental cues, including the cell density of the intestinal normal flora (through the floral-derived AI-3 signal) and the epinephrine/norepinephrine produced …
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The Functional Characterization of QSEC a Bacterial Adrenergic Receptor and the LuxR Homologue SDIA in EHEC
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a human pathogen responsible for outbreaks of hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). The histidine sensor kinase QseC is an inner membrane adrenergic receptor which responds to the bacterial signal autoinducer-3 (AI-3) and …
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The Role of Host Hormones and Metabolites in the Regulation of Virulence in Enterohemorrhagic Escherichia coli (EHEC)
… enterohemorrhagic Escherichia coli O157:H7 (EHEC) that causes hemorrhagic colitis, sense diverse environmental signals, and use them as cues for differential gene regulation and niche adaptation. This allows for a temporal and energy efficient up-regulation of EHEC virulence factors that is …
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Structural and Mechanistic Roles of Novel Chemical Ligands on Quorum Sensing Transcription Regulator SdiA in Enterohemorrhagic Escherichia coli
… in the human pathogen enterohemorrhagic E. coli (EHEC) O157:H7. Although EHEC causes foodborne infections worldwide that result in bloody diarrhea and hemolytic uremic syndrome (HUS), cattle is the major reservoir of EHEC. In cattle, EHEC colonizes predominately at the recto-anal junction (RAJ). …
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Characterization of QSEA and QSED in the Quorum Sensing Cascade of Enterohemorrhagic Escherichia Coli
Enterohemorrhagic E. coli O157:H7 (EHEC) is an enteric pathogen that has been implicated in many outbreaks of bloody diarrhea worldwide. EHEC senses its environment through quorum sensing, a mechanism by which bacteria use chemical signals, termed autoinducers, to regulate key genes. In the …
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Characterisation of Escherichia coli of the bovine intestinal tract
Enterohaemorrhagic E. coli (EHEC) are important gastrointestinal pathogens of humans. E. coli serotype O157:H7 is the EHEC most commonly associated with human illness. E. coli O157:H7 is carried asymptomatically by cattle which form an important reservoir for the bacterium. E. coli O157:H7 has been …
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The Characterization of Quorum Sensing E. Coli Regulators E,F, and G (Qse EFG) and Their Role in Pathogenesis
Escherichia coli O157:H7 (EHEC) causes hemorrhagic colitis and life-threatening hemolytic uremic syndrome (HUS) worldwide. EHEC colonizes the large intestine and adheres to intestinal epithelial cells by forming attaching and effacing lesions (AE). These lesions result in the rearrangement of the …
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Untersuchungen zur Regulation von Shiga-Toxin 2 und zur Attenuierung von enterohämorrhagischen Escherichia coli
Enterohämorrhagische Escherichia coli (EHEC) gehören zu den wichtigsten der sich in jüngster Zeit verbreitenden Pathogene und verursachen die verschiedensten Durchfallerkrankungen von unblutiger Diarrhö bis zu hämorrhagischer Kolitis, oftmals unter Ausprägung von lebensbedrohlichen …
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The Functional Characterization of the LysR-Type Transcriptional Regulator QseD and the SorC-Type Transcriptional Regulator LsrR in Enterohemorrhagic Escherichia coli
Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a human pathogen responsible for numerous outbreaks of hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS) throughout the world. EHEC is able to sense and respond to biotic cues from its environment, such as the human host produced …
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Biochemical Studies of EA22, A Protein Involved in The Bacteriophage Lysogenic-Lytic Decision and the Virulence of Clinically Relevant Serotypes of E. Coli
Enterohemorrhagic Escherichia coli (EHEC) infections are associated with short term gastrointestinal problems, but in some cases, it can lead to more life-threatening conditions. The pathogenicity of EHEC Is supported by an endogenous, dormant bacteriophage that persists in the bacterium as a …
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Molekulare Untersuchungen zu Virulenzfaktoren und Klonalität enterohämorrhagischer Escherichia coli der Serogruppe O103
… die Hypothese einer klonalen Entwicklung von EHEC O103:H2 bestätigen. Die in Clustern angeordnete Übereinstimmungsrate der RAPD-Fragmentierungsmuster und der Plasmidrestriktionen zeigen diese Ähnlichkeit innerhalb der Serogruppe auf, während Gemeinsamkeiten mit dem O157-Referenzstamm sich auf …
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The Characterization of the Fucose Sensing Kinase (FUSK) and the Fucose Sensing Response Regulator (FUSR) and Their Role in Virulence Regulation in Enterohemorrhagic Escherichia Coli O157:H7
EHEC causes outbreaks of bloody diarrhea worldwide, by colonizing the human large intestine, where it forms attaching and effacing (AE) lesions on the intestinal epithelium. AE lesion development requires the presence of the locus of enterocyte effacement (LEE) that encodes for a molecular syringe, …
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Proteomics approach on the identification of virulence factors of enteropathogenic and enterohemorrhagic Escherichia coli (EPEC and EHEC) and further characterization of two effectors: EspB and NleI
… and enterohemorrhagic Escherichia coli (EPEC and EHEC) are two closely related human pathogens responsible for food-borne epidemics in many countries. Several virulence factors together with some putative proteins were identified from the extracellular proteomes of EPEC and EHEC. One of the major …
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Tagging of the type three secretion system basal apparatus of Enterohaemorrhagic Escherichia coli 0157:H7
… pathogens Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 possesses a type III secretion system (T3SS). The T3SS translocates effector proteins into host cells during infection and consists of a basal apparatus that spans the inner and outer membranes and a needle and filament complex. The …
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Post-Transcriptional Regulation of Virulence Genes by GlmY and GlmZ in Enterohemorrhagic E. Coli
Enterohemorrhagic E. coli O157:H7 (EHEC) is a major cause of foodborne illness and hemolytic uremic syndrome (HUS) throughout the world. One of the major virulence factors in this pathogen is a type III secretion system (T3SS) encoded by the locus of enterocyte effacement (LEE). EHEC uses this …
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Zelluläre Funktionsstudien zum Wirkungsmechanismus von Shiga Toxinen bei mikro- und makrovaskulären Endothelzelllinien
… Organen. Stx, die Hauptvirulenzfaktoren der EHEC, bestehen aus einer enzymatisch aktiven A-Untereinheit und fünf identischen B-Untereinheiten. Die Familie der Stx umfasst zwei Hauptgruppen, Stx1 und Stx2, welche 53 bzw. 64 Prozent Sequenzidentität in ihrer A- bzw. B-Untereinheit aufweisen. …
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Evaluation of a gold nanoparticle platform as highly immunogenic and protective therapy against Burkholderia mallei, B. pseudomallei, and Enterohemorrhagic Escherichia coli O157:H7
… model of Enterohemorrhagic Escherichia coli (EHEC). Furthermore, we showed that vaccination with AuNP-coupled to EHEC-specific antigens elicits strong systemic and mucosal response associated with protection against EHEC colonization. This work proposes to bridge the properties of subunit …
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Cellular subversion: towards a complete repertoire of type-III secretion system effectors in enterohaemorrhagic Escherichia coli O157:H7
Enterohaemorrhagic Escherichia coli (EHEC) O157:H7 is a formidable pathogen that uses a type-III secretion system to inject bacterial ‘effector’ proteins directly into host cells. Most effectors that are encoded within the locus of enterocyte effacement (LEE) have been studied extensively. This …
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Efficacy and impact of sanitizers in controlling pathogenic bacteria on irrigation water
… achieving a 3-log reduction of E. coli O157:H7 (EHEC), Salmonella (SM), or Listeria monocytogenes (LM). Additionally, the study examined their corrosive effects on aluminum and stainless steel, as well as their impact on plant and soil chemical and physical properties. Sanitizer evaluations were …
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