Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"EGR2"”.
-
Early Growth Response Protein 2 (EGR2) regulation of B cell differentiation in lupus-prone mice
… transcription factor Early Growth Response 2 (EGR2), a key regulator of immune cell function, was markedly upregulated in murine and human lupus lymphocytes. Further, we reported that conditional deletion of Egr2-/- in lymphocytes in lupus-prone B6/lpr mice suppressed pathogenic anti-dsDNA …
-
Investigation of MicroRNAs in Lupus-Prone Mice
… conditional deletion of Early Growth Response-2 (EGR2) (Egr2-/- B6/lpr), another knockout mouse developed in our laboratory. Egr2 has recently been shown to regulate immunity and autoimmunity and play a role in lupus. An unexpected observation is that Egr2-/-B6/lpr mice had significantly reduced …
-
TrkB and gene expression
… class of genes. This group consisted of: egr1, egr2, c-fos and mGIF/Tieg1. These genes were found to be differentially regulated in the signaling point mutant mice. Although the promoter of mGif/TIEG1 is not yet characterized and also the function of this gene is not completely clear, egr1, egr2 …
-
The Role of TCR Engagement Strength in Antitumor CD8 T Cell Exhaustion
… involves increased chromatin accessibility at Egr2 and Tcf1 target loci. Collectively, my dissertation work reveals a previously unappreciated and coun- terintuitive role of TCR stimulation in preserving Tpex and highlights TCR-dependent self-renewal of Tpex during tumor progression. These …
-
TRANSCRIPTIONAL CONTROL OF Ca2+ SIGNALING IN T CELLS
… whereas significant roles for EGR1, EGR2 and EGR3 in T cell development and function have been established, a role for EGR4 has not, hitherto been elucidated. In the second half of this thesis, using qPCR, I reveal that EGR4 expression is stimulated by TCR engagement in primary double …