Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"EGR1"”.
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The Epigenetic Role of EGR1 during Postnatal Mammalian Brain Development
… at different developmental stages. We predicted Egr1, a transcriptional factor with important roles in neuron maturation, synaptic plasticity, long-term memory formation and learning, plays an essential role in brain epigenetic programming. We performed EGR1 ChIP-seq and validated that thousands …
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EARLY GROWTH RESPONSE 1 (EGR1) AS A TUMOR SUPPRESSOR AND APOPTOSIS INDUCER IN RHABDOMYOSARCOMA
EGR1, one of the immediate-early response genes, plays an important role as a mediator for transmitting extracellular stimuli. EGR1 is down regulated in many cancers. Many studies show that it functions as a tumor suppressor gene in a variety of cancers. EGR1 also acts as an oncogene in number of …
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Evaluation of Sex Differences in the Hippocampus and Pituitary of Egr1 conditional knockout mice mediated by Nestin-Cre
Early growth response 1 (Egr1) is a transcription factor critical for learning and memory in the hippocampus and pituitary cell differentiation. Egr1 has been shown to extend continuation of the long-term potentiation in the hippocampus and is credited for forming long-term memories. The …
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The Interaction of Early Growth Response Gene 1 and Myocyte Enhancer Factor 2C in the Murine Brain Cortex
Early growth response gene – 1 (Egr1) encodes a protein widely present in mammalian body, such as connective tissue, cardiac tissue, the liver, and the brain. As a transcription factor (TF), it is involved in processes that take place in the endocrine, digestive, immune, musculo-skeletal and …
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Analysis of B lymphocyte activation and differentiation by expression profiling
… of mice. The zinc-finger transcription factor EGR1 is an immediate early gene induced upon Ag-binding and BCR engagement in B cells. EGR1 promotes B cell differentiation and maturation at the progression from pro-B to pre-B and into the mature B cell stages. The main hypothesis of this study …
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Mechanism of transcranial focused ultrasound regulating the neuronal activity of the retrosplenial cortex
… levels of early growth factor response 1 (Egr1). These tFUS-activated Egr1 cells were mainly neurons. Through multi-channel in vivo recording, it was found that the spike rate of pyramidal neurons and interneurons decreased remarkably under tFUS. A greater proportion of spike rate in …
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Classification and Processing of Communication Calls in Little Brown Bats, Myotis Lucifugus
… the processing of communication signals, using egr1 (an immediate early gene) as a molecular marker for brain activation. Three species-specific signals were included -- downward FM (DFM), courtship, and echolocation. Reversed DFM and silence groups were used as a comparison for basal activity. …
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TRANSCRIPTIONAL CONTROL OF Ca2+ SIGNALING IN T CELLS
… proteins is regulated by the EGR family members, EGR1 and EGR4. Additionally, transcriptional regulation of PMCA inhibition by EGR1 and EGR4 is required for efficient activation of T cells. Interestingly, whereas significant roles for EGR1, EGR2 and EGR3 in T cell development and function have …
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Investigation of molecular and cellular events associated with beta cell function and elucidation of extracellular RNAs as potential biomarker for diabetes
… from Type 2 diabetes and controls. Pdx1, Npy, Egr1, Pld1, Chgb, Ins1, Ins2, and betaactin from MIN6(L), MIN6(H), and MIN6 B1 cells and their CM suggests that beta cells transcribe and release these mRNAs into their culture environment.This study was subsequently translated to analysis of serum …
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TrkB and gene expression
… others class of genes. This group consisted of: egr1, egr2, c-fos and mGIF/Tieg1. These genes were found to be differentially regulated in the signaling point mutant mice. Although the promoter of mGif/TIEG1 is not yet characterized and also the function of this gene is not completely clear, …
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Investigation of Sensory Cell-Specific Changes in Gene Expression in Microrna-183 Family Knockout Mouse Inner Ear From Bulk RNA Sequencing Analysis
… analysis, a total of 19 GOIs were identified: Egr1, Nnat, Plod2, Rims3, Cntn1, Idh2, Cfl1, Anp32b, Palld, Hspa2, Kif5a, Map1b, Zbtb20, Plag1, Prkce, Amotl2, Slc44a2, Dcx, and Sncb. These 19 genes stood out due to their expression patterns after KO, their cell-specific expression in single-cell …
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Ageing and regeneration-associated transcriptional state transitions and tumour-stroma interaction in early renal carcinogenesis
… transcription factors (TFs) including Fos, Junb, Egr1 and Atf3. Interestingly, these 4 TFs showed upregulation in normal proximal tubule (PT) cells as mice get older. The second wave showed upregulation of Sox4 and Sox9, which are involved in kidney epithelial cell regeneration. Single cell ATAC …
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Molecular genetics of the imprinted gene - SPROUTY3 (SPRY3)
… of SPRY3 expression by transcription factors EGR1, ZNF263 and PAX6. Spry3 over-expression in mouse superior cervical ganglion cells inhibits axon branching and Spry3 knockdown in those cells increases axon branching, consistent with known functions of other Sprouty proteins. Novel SPRY3 …
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Simultaneous computational discovery of DNA regulatory motifs and transcription factor binding constraints at high spatial resolution
… and novel pairs such as c-Fos:c-Jun/USF1, CTCF/Egr1, and HNF4a/FOXA1. I also discovered a complex spatial binding relationship involved 6 key regulatory factors in mouse embryonic stem (ES) cell that is likely to be functional in ES cell gene regulation. Such computational discoveries propose …
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Genetic Networks Modulating Retinal Injury
… example, transcriptional factors such as Fos and Egr1 define the early response, whereas, glial reactive markers such as Gfap and Cd81 define the sustained response. Second, three specific genomic loci modulate coordinated changes in gene expression in mouse brains: regulatory loci on chromosomes …
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Biochemische und Molekularbiologische Charakterisierung der Wechselwirkungen zwischen Humanen Thrombozyten und Endothelzellen
… Expression von Transkriptionsfaktoren (c-Jun, Egr1, CREB2), Wachstumsfaktoren (PDGF) sowie von Adhäsionsrezeptoren für extrazelluläre Matrixproteine (Integrin av, Integrin b1) gefunden. Diese Faktoren weisen darauf hin, daß aktivierte Thrombozyten die Migration und Proliferation der …
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The role of Wilms’ Tumor gene product (WT1)in CD95-mediated apoptosis in T-cell leukaemias
… Egr family and has target sequences similar to Egr1. WT1 is expressed during the early stages of haematopoiesis and has been implicated in leukaemogenesis. Its role in leukaemias is controversial as it is either found to be mutated or overexpressed, and overexpression is linked with more …
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The role of extracellular signal-regulated kinases (ERKs) in T lymphocytes
… such as CD25 and transcription factors like EGR1. These results provide a comprehensive understanding of the role of ERK1/2 in antigen receptor signaling in naïve T cells.<br/><br/>The second part of this study consisted of the evaluation of the ERK1/2 role in TCR activated cytotoxic T …
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Hemmung der humanen Telomerase Reverse Transkriptase-Expression mittels synthetischer Nukleinsäuren in Harnblasenkarzinomzellen
… Stressantwort assoziiert sind (u.a. ATF3, EGR1, GADD45). Diese Expressionsmuster stimmten in hohem Maße mit denen überein, die durch Transfektion mit AS-ODN gegen andere Targets erhalten wurden. Diese Ergebnisse deuten auf eine, zumindest teilweise, durch off-Targeteffekte ausgelöste …
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Hormones, Simulated Microgravity and Hypergravity affect Bone and other Physiological Systems in Zebrafish Larvae
… of regulatory genes (hes5, sox10, lgals3bp, egr1, edn1, fos, fosb, klf2, gadd45ba and socs3a) whose expression was consistently affected by the transition from hyper- to normal gravity.
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