Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"EGFR targeting"”.
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Innovating surgery for oral squamous cell carcinoma with targeted fluorescent and magnetic tracers
… this thesis are Panitumumab-IRDye800CW, an EGFR-targeting fluorophore used for fluorescence molecular imaging, and FerroTrace, a superparamagnetic iron oxide nanoparticle (SPION) that has been engineered with mannose end targets for macrophage-specific binding to aid SLNB.
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The Development of a Novel Peptide-Drug Conjugate for Treating Triple-Negative Breast Cancer
… problems. A peptide-drug conjugate (PDC) targeting overexpressed epidermal growth factor receptor (EGFR) in TNBC cells was synthesized to increase the uptake of drug by TNBC cells, thereby improving the safety and efficacy of chemotherapeutic doxorubicin (Dox) in TNBC treatment. This PDC …
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Mechanistic Characterization of RTK Signaling Networks Using Phosphoproteomic Approaches
… a predictive model that can inform future targeting strategies in disease. Here, I present an overview of the value phosphoproteomics adds to cancer research, and the insights we can gain when combined with Y-to-F mutational approaches to gain mechanistic understanding underlying protein …
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IMPLEMENTATION OF 3D CELLULAR MODELS FOR DRUG AND TOXIN TESTING IN HEALTHY AND CANCEROUS TISSUE
… in 3D colo rectal cancer organoids displayed EGFR pathway mutation targ eting drug s are given an advantage over the 2D cultures; the reverse was true for most non - EGFR targeting drugs. Additionall y, IHC staining showed upregulation of EGFR and its downstream components in 3D over 2D. …
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Polymerizable Peptide Monomers for the Targeted and Intracellular Delivery of Cancer Therapeutics
… of cancer, peptides hold great potential as both targeting and therapeutic agents. One particularly promising anti-cancer strategy is peptides derived from the third Bcl-2 homology domain (BH3), which antagonize pro-survival Bcl-2 proteins and induce apoptosis. Unfortunately, before the clinical …
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Targeted magnetic hyperthermia for lung cancer
… treatment of lung cancer. We developed EGFR-targeted, inhalable SPIO nanoparticles for magnetic hyperthermia of NSCLC. EGFR targeting resulted in 50% higher concentration of iron oxide in the lungs 1 week post inhalation, when compared to non-targeted SPIO nanoparticles. Magnetic …
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The antitumor activity of tumor-targeted RNA replicase-based plasmid DNA
… activity of the RNA replicase-based plasmid by targeting it into tumors cells was also evaluated. An epidermal growth factor (EGF)-conjugated, PEGylated cationic liposome was developed to deliver the RNA replicase-based plasmid, pSIN-beta, into EGFR-over-expressing human breast cancer cells …