Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"EGFR ligand"”.
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Untersuchungen zum Mechanismus der liganden-vermittelten Transaktivierung des epidermalen Wachstumsfaktor Rezeptors
Der epidermale Wachstumsfaktor Rezeptor (EGFR) wird nach Stimulation von G-Protein gekoppelten Rezeptoren (GPCR) tyrosinphosphoryliert, sog. Transaktivierung, und trägt zur mitogenen Signalübertragung verschiedenster GPCR in normalen als auch in humanen Krebszellen bei. Im Rahmen dieser Arbeit …
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Mechanotransduction via airway epithelial cells : the effect of compressive stress
… of the epidermal growth factor receptor (EGFR) - MAP kinase (ERK) signaling pathway. Furthermore, specialized real-time high-speed imaging revealed an exponential decrease in the volume of the compliant lateral intercellular space (LIS) separating neighboring cells. The measured LIS volume …
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Epiregulin as a Novel Target for Antibody-Drug Conjugate Development for the Treatment of Colorectal Cancer
… (EREG), is an epidermal growth factor receptor (EGFR) ligand that is highly expressed in CRCs of different subtypes and mutational statuses with low expression in normal tissues. Here, we have characterized the role of EREG in CRC progression, generated and evaluated the first EREG-targeted ADC, …
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EGFR signaling regulates synaptic connectivity via Gurken
… I describe a role for the EGF receptor and its ligand Gurken in target selection of octopaminergic Type II neurons in the Drosophila neuromuscular system. Mutants in happyhour, a regulator of EGFR signaling, form ectopic Type II neuromuscular junctions. These ectopic innervations are due to …
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Neutrophil Regulation of Colitis
… production of amphiregulin (AREG), a member of EGFR ligand family. Upon the induction of an intestinal inflammatory state, AREG signals through the EGFR pathway to induce epithelial junction formation, as a way to restore epithelial function and ameliorate colitis. Taken together, our studies …
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The function of Drosophila Integrin-Dim7-Elmo-Mbc→Rac signaling pathway in the muscle attachment formation and maintenance
… the secreted Epidermal growth factor receptor (Egfr) ligand Vein to regulate tendon cell maturation. In the muscle, Dim7 acts upstream to recruit the Elmo-Mbc signaling module to the ends of muscles for stable muscle attachments. Both Dim7 and Elmo are localized to the muscle attachment sites …
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Application of fluorescence resonance energy transfer to study syndecan-3 signaling on the surface of neural cells
… acts as a signaling receptor upon binding of its ligand, heparin-binding growth associated molecule (HB-GAM; also known as pleiotrophin), which activates the cortactin c-Src signaling pathway. This leads to rapid neurite extension in neuronal cells, which makes syndecan-3 an interesting …
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Innate immunity in defence against infection and tissue repair of the urinary tract
… AREG, is an epidermal growth factor receptor (EGFR) ligand that is expressed by a variety of activated immune cells, including macrophages and is a vital mediator of immune responses in infection and tissue repair. Using microarray analysis, we found AREG expression was higher in the renal …
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REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
The epidermal growth factor receptor (EGFR) plays a pivotal role in physiological cellular processes, but its aberrant activation is linked to cancer progression. Endocytosis is a critical regulator of EGFR activity. We have previously identified a novel endocytic route of the EGFR, non-clathrin …
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Quantitative Analysis of the Spatial and Temporal Organization of Cell Surface Receptors
Appendix B contains a previously published article, which is referenced below as a related citation.