Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 8 of 8 for “"EGFR inhibitors"”.
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Study of Potential Drug Interactions of Epidermal Growth Factor Receptor Inhibitors (EGFR inhibitors) in the Treatment of Non-Small-Cell Lung Cancer // Проучване на потенциални лекарствени взаимодействия при използване на инхибитори на рецептора на епидермалния растежен фактор (EGFR-инхибитори) при лечение на недребноклетъчен белодробен карцином
… cancer with epidermal growth factor receptor inhibitors.
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Interrogating therapeutic resistance to oncogenic KRASG12C-based therapies in colorectal cancer
… target. The recent approval of novel covalent inhibitors selective for KRASG12C mutation have entered the clinic, which has not only marked a major milestone in cancer drug discovery but has also intensified efforts to directly target other KRAS mutations that have also successfully entered the …
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Understanding Acquired Resistance to Lapatinib In Breast Cancer Cells
… through epidermal growth factor receptor (EGFR/ErbB) family members plays a very important role in regulating proliferation, development, and malignant transformation of mammary epithelial cells. ErbB family members are often over-expressed in human breast carcinomas. Lapatinib is an ErbB1 …
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A two-pronged approach towards the development of novel therapeutics for advanced endometrial cancer
… (MUC1)-driven epidermal growth factor receptor (EGFR) expression and signaling. MUC1 is a large, heavily glycosylated transmembrane protein that functions to lubricate surfaces, provides protection from external insult and plays an important role in embryo implantation. EGFR is a receptor …
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EGFR deficiency results in defective hair follicle cycling, resistance to chemotherapy-induced alopecia, and cutaneous inflammation
… patients with epidermal growth factor receptor (EGFR) inhibitors causes perifollicular inflammation in the skin. Mouse models with EGFR deficiency predicted this folliculitis and revealed that abrogation of EGFR disrupts hair follicle cycling. Hair follicles transition between the anagen growth …
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Combined Inhibition of Lysine-Specific Demethylase 1 and Kinase Signaling as a Preclinical Treatment Strategy in Glioblastoma
… to tumor growth and treatment resistance. Inhibitors of LSD1 have shown preclinical promise but have had limited clinical development for glioblastoma. Given the frequent kinase pathway alterations in glioblastoma, the interplay between LSD1 inhibition and kinase signaling pathways was …
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Quantitative mass spectrometry analysis of the early signaling dynamics of the epidermal growth factor receptor
… biology is the Epidermal Growth Factor Receptor (EGFR), which has long been associated with diseases including cancer. Despite development of several EGFR inhibitors, the clinical efficacy of targeting this receptor has been minimal. This shortcoming is attributable primarily to the incredible …
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Design, Synthesis and Biological Screening of Novel Cucsinspired Estrone Analogues Towards Treatment of Hepatocellular Carcinoma
… to bind to the Epidermal Growth Factor Receptor (EGFR). Due to the limited quantities of CUCS upon isolation and the challenges of total synthesis of CUCS, therefore estrone skeleton were used as a starting scaffold to synthesize CUCS-inspire estrone analogues (CIEA) targeting HCC. Molecular …