Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"EGFR inhibitor"”.
-
Mechanisms of Epidermal Growth Factor Receptor Regulation of Epidermal Proliferation and Skin Tumorigenesis in Response to Ultraviolet Irradiation.
The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, regulates both skin biology and carcinogenesis. We hypothesized that EGFR-dependent signal transduction increases normal keratinocyte proliferation and proliferation in response to ultraviolet (UV) irradiation, resulting in …
-
Interrogating therapeutic resistance to oncogenic KRASG12C-based therapies in colorectal cancer
… target. The recent approval of novel covalent inhibitors selective for KRASG12C mutation have entered the clinic, which has not only marked a major milestone in cancer drug discovery but has also intensified efforts to directly target other KRAS mutations that have also successfully entered the …
-
SYNTHETIC AND MECHANISTIC STUDIES OF PRECIOUS METAL-MODIFIED TYROSINE KINASE INHIBITORS
… targeted therapies such as tyrosine kinase inhibitors (TKIs) make up an important class of oncology drugs. Targeting of cancer cells harboring oncogenic molecular targets, especially signaling kinases, with precision medicines, while sparing the majority of normal healthy cells, has led to …
-
Role and Regulation of Epha2 In Pancreatic Cancer
… in mouse models of PDAC. In cells where an EGFR inhibitor reduced phospho-Erk, expression of EphA2 was also reduced, indicating that changes in EphA2 levels may allow monitoring the effectiveness of anti-Ras/MEK/ERK therapies. In conclusion, EphA2 levels may be a good prognostic factor for …
-
Role Of Thromboxane Receptor-Alpha In Prostate Cancer Progression
… factor Amphiregulin (AREG) and its receptor EGFR. Introduction of an expression plasmid encoding TPα into another PCa cell line, PC3 (PC3-TPα), led to a similar phenotype in response to IBOP, thereby confirming a link between TPα and over expression of AREG and EGFR. </p> <p> Increase in AREG …
-
The novel role of epidermal growth factor (EGF) in the regulation of ion channels in the calu-3 submucosal cell line
… increased initial current at one hour via a EGFR-PI3K-PKC-δ-KCNN4/KCNQ1 signalling pathway. Similarly, preincubation with EGF also decreased forskolin induced short circuit current compared to untreated monolayers at 1 to 3 hours, with a recovery at 24 hours. The decreases were found to be …
-
Cell replacement strategies in the central nervous system in two mouse models of neuronal damage: potential therapeutic targets and promising drugs
… injury and the SVZ release TGF¿, activating the EGFR expressed in the neuroblasts membrane inducing their proliferation, delaying maturation and negatively regulating migration. The inactivation of this signaling pathway with the EGFR inhibitor Afatinib stimulates neuroblast migration toward the …
-
Combating Resistance To Epidermal Growth Factor Recpetor Inhibitors In Triple Negative Breast Cancer
… expression of epidermal growth factor receptor (EGFR), EGFR targeted inhibitors, such as gefitinib (GEF), have yet to demonstrate efficacy. Using mass spectrometry to identify pathways that remain activated in the presence of GEF, we found that components of the mTOR signaling pathway remain …
-
Molecular Mechanisms by Which HSP90 Inhibition in the Spinal Cord Enhances Opioid Receptor Signaling
… (AMPK) and Epidermal Growth Factor Receptor (EGFR) were downregulated by 26%, while the Dual Specificity Phosphatase 15 (DUSP15) was upregulated by 35%. This result suggested that a reduction in AMPK and EGFR activity and an increase in DUSP15 activity could lead to enhanced opioid signaling …
-
NOVEL THERAPEUTIC STRATEGIES IN LUNG CANCERSTRONG BIOLOGICAL BIAS FOR ALK INTRON 19 BREAKPOINTS IN NON-SMALL LUNG CANCER
… the way to targeted therapy with tyrosine kinase inhibitors. EML4-ALK translocations are detected in 4-8 % of NSCLC and define a specific subtype of oncogene-driven lung cancer. While different EML4-ALK variants are defined by different breakpoints in the EML4 gene, most frequently located in …
-
Dissecting the molecular mechanisms of therapeutic resistance in cancer
… NSCLC cell-lines. SFK inhibition also prevented EGFR inhibitor-induced EMT and drug resistance in NSCLC cells both in vitro and in vivo. Mechanistically, SFK activation stabilized ZEBI by promoting ERK1/2-mediated phosphorylation on three serine residues, S583, S646, and S679. Consequently, MEK …
-
The effects of various combinations of different classes of anticancer drugs and tyrosine kinase inhibitors on the human MCF-7 and triple-negative MDA-MB 231 breast carcinoma cell lines
… therapy. The epidermal growth factor receptor (EGFR) is abnormally activated in many cancers and its signal transduction pathways play an important role in regulating cell proliferation and survival. It is often overexpressed in TNBC. P-glycoprotein (P-gp) is a transmembrane glycoprotein …
-
The Role of Bcl-xL and EGFR in the Malignant Progression of Neurofibromatosis type 1
… of epidermal growth factor receptor (EGFR) in Schwann cells (SCs) is frequently observed in NF1-associated MPNST tissues, I first examined whether the basal EGFR expression levels were different between SCs derived from normal tissues or MPNSTs. By performing a comparison analysis …