Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 390 for “"EGFR"”.
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Methylation of Egfr By Arginine Methyltransferase Prmt1 Enhances Egfr Signaling and Cetuximab Resistance
… of epidermal growth factor receptor (EGFR) intracellular domain are well known regulators of EGFR functions whereas those of its extracellular domain remain relatively unexplored. Here, we report that methylation at R198 and R200 of EGFR extracellular domain by protein arginine …
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EGFR signaling regulates synaptic connectivity via Gurken
… system. Mutants in happyhour, a regulator of EGFR signaling, form ectopic Type II neuromuscular junctions. These ectopic innervations are due to inappropriate target selection. I demonstrate that EGFR signaling is necessary and sufficient to inhibit synaptic target selection by these …
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Igfbp2 Potentiates Egfr-Stat3 Signaling In Glioma
… overexpression lead to aberrant activation of EGFR, which subsequently activates STAT3 signaling. Furthermore, we demonstrate that IGFBP2 augments the nuclear accumulation of EGFR to potentiate STAT3 transactivation activities, via activation of the nuclear EGFR signaling pathway. Nuclear …
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A MULTIORGANELLE PLATFORM REGULATES EGFR ENDOCYTOSIS AND SIGNALLING
… of the epidermal growth factor receptor (EGFR). The internalization of the EGFR can occur through different mechanisms. Clathrin-mediated endocytosis (CME) operates at all concentrations of EGF and in all cell contexts, directing the majority of receptors towards recycling. In contrast, …
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The Role of EGFR Signaling in Gonadotropin-Induced Steroidogenesis
… receptors and Epidermal Growth Factor Receptor (EGFR) is critical for steroidogenesis in all three major steroid-producing tissues. We have recently characterized the intracellular signals regulating Luteinizing Hormone (LH) -induced steroid production in Leydig cells, demonstrating a linear …
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The significance of the EGFR pathway in malignant pleural mesothelioma
IntroductionEGFR, MTOR and COX2 are up regulated in malignant pleural mesothelioma (MPM). In this study we aimed to determine the expression of Lipoxygenase enzymes (LOX), absence of PTEN protein expression and the cytotoxic effect of EGFR, MTOR and COX2 inhibitors in MPM.Materials and …
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Quantitative studies of EGFR autocrine induced cell signaling and migration
Epidermal growth factor (EGF) receptor autocrine and/or paracrine signaling plays an important role in normal epithelial cell proliferation, survival, adhesion and migration. Aberrant expression of the EGF receptor and its cognate ligands have been implicated in various types of cancers, hence EGF …
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EGFR & HER2 trafficking and signaling dynamics : experimental and modeling studies
EGFR and HER2 expression levels have distinguished themselves as important factors in contributing to various types of cancers including breast and ovarian cancers, but quantitative linkages between receptor expression levels and aberrant cell behaviors are not well understood. The ability to …
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EGFR Signaling Is Necessary for Gonadotropin-Induced Steroidogenesis and Oocyte Maturation
… The soluble EGF molecules then stimulate EGFRs on granulosa cells (and possibly theca cells), leading to activation of StAR and increased steroidogenesis. The steroids in turn act upon the oocyte to promote maturation, allowing for ovulation to occur. Notably, MMPs appear to be important …
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Defining The Role of Egfr Acetylation In Cellular Processes: Clinical Implications
<p> Epidermal growth factor receptor (EGFR) is a cell membrane tyrosine kinase receptor and plays a pivotal role in regulating cell growth, differentiation, cell cycle, and tumorigenesis. Deregulation of EGFR causes many diseases including cancers. Intensive investigation of EGFR alteration in …
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The Effects of Aging on EGFR/pSTAT3-Dependent Gliovascular Structural Plasticity
Astrocytes comprise the most abundant cell population in human brain (1). First described by Virchow as being 'glue' of the brain (2), modern research has truly extended our knowledge and understanding regarding the vast array of roles these cells execute under normal physiological conditions. …
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Development and characterization of anti-EGFR protein-drug conjugates for tumor therapy
… The epidermal growth factor receptor (EGFR) is a validated tumor marker overexpressed in various cancers such as squamous cell carcinoma (SSC) of the head and neck and gliomas. This thesis examined the development of bivalent anti-EGFR protein-drug conjugates, analyzed _in vitro_ and …
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Characterisation of the molecular mechanisms of EGFR signal transactivation in human cancer
… metalloprotease-dependent transactivation of the EGFR, and EGFR characteristic downstream signalling events were observed in response to stimulation with physiological concentrations of GPCR agonists such as the mitogens LPA and S1P as well as therapeutically relevant concentrations of …
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A Role For Lipid Rafts In Egfr Tki Resistance In Breast Cancer
… in 60% of these cases. Also, over-expression of EGFR correlates with poor patient prognosis. Unfortunately, inhibitors of EGFR have shown little clinical efficacy in basal-type breast cancers. We have utilized basal-type breast cancer cell lines to determine a potential mechanism of resistance to …
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Egfr Modulates Microrna Maturation In Response to Hypoxia Through Phosphorylation of Argonaute2
… in response to stresses. Here, we show that EGFR, a well-characterized oncogene in human cancers, suppresses the maturation of specific tumor-suppressor-like miRNAs in response to hypoxic stress through phosphorylation of Argonaute2 (Ago2) at Tyr393. The association between EGFR and Ago2 is …
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EGFR-Targeted Polymeric Micelles For Targeted Pc 4-PDT Of Oropharyngeal Tumors
… micelles, (2) Modify micelle surface with EGFR-specific ligands and investigate cancer cell targeting of the surface-modified micelles in vitro, and, (3) Investigate targeted PDT effects on SCC cell lines in vitro and suitable animal models in vivo with Pc 4- loaded EGFR-targeted micelle …
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