Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"EGF receptor"”.
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Characterization of Ligand-Induced Conformational Changes in the EGF Receptor
… of ligand-induced conformational changes in the EGF receptor by Katherine S. Yang Doctor of Philosophy in Biochemistry Washington University in St. Louis, 2009 Professor Linda Pike, Chairperson The epidermal growth factor: EGF) receptor is a classical receptor tyrosine kinase that mediates …
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EGF receptor-mediated fibroblast signaling and motility : role of nanoscale spatial ligand organization
Cell motility is often governed by growth factor receptor and integrin adhesion receptor interactions with the extracellular environment followed by collaborative intracellular signaling. While integrin ligands are necessarily bound within the extracellular matrix to permit force transduction by …
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Quantitative analysis and modulation of the spatial operation of the EGF receptor autocrine cell signaling system
The spatial localization of EGFR autocrine systems is a critical factor for tissue development and homeostasis. It is difficult to analyze these systems, however, because they are both self-contained and recursive. To understand how cellular parameters influence autocrine activity, we investigated …
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Quantitative studies of EGFR autocrine induced cell signaling and migration
Epidermal growth factor (EGF) receptor autocrine and/or paracrine signaling plays an important role in normal epithelial cell proliferation, survival, adhesion and migration. Aberrant expression of the EGF receptor and its cognate ligands have been implicated in various types of cancers, hence EGF …
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Down-modulation of the apoptosis receptor Fas and the EGF receptor by the adenovirus E3/10.4-14.5K proteins requires the concerted action of two distinct transport signals
… to modulate cell surface expression of the EGFR and selective members of the TNF/NGF receptor superfamily, namely Fas/CD95 and TRAIL-R1, whereas TRAIL-R2 modulation additionally requires E3/6.7K. In a process referred to as receptor down-regulation, 10.4-14.5K relocates receptor targets from …
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The Ubiquitin Ligase Ube4B Is Required For Efficient Epidermal Growth Factor Receptor Degradation
… back to the plasma membrane. In the case of receptor tyrosine kinases (RTKs), such as epidermal growth factor (EGF) receptor, this important sorting step determines whether a protein returns to the surface to participate in signaling, or whether its signaling properties are inactivated …
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The Role of Tyrosine Kinase Growth Factor Receptors in Psoriatic Epidermal Hyperplasia: Analysis of Growth Factor Synergy in Cultured Human Keratinocytes and Receptor Expression in Psoriatic Skin
… in the disease. The epidermal growth factor (EGF) receptor pathway is an important mediator of keratinocyte growth and both ligand and receptorcomponents of this pathway are abnormally expressed in hyperproliferative epidermis. In contrast, little is known about the function of other growth …
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The Role of EGFR Signaling in Gonadotropin-Induced Steroidogenesis
… that cross talk between G protein-coupled receptors and Epidermal Growth Factor Receptor (EGFR) is critical for steroidogenesis in all three major steroid-producing tissues. We have recently characterized the intracellular signals regulating Luteinizing Hormone (LH) -induced steroid …
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EGFR Signaling Is Necessary for Gonadotropin-Induced Steroidogenesis and Oocyte Maturation
… as the subsequent role of steroids and their receptors on oocyte and follicle development. Initial work focused on transcriptionindependent, or nongenomic, steroid-induced maturation of oocytes. We demonstrated for the first time that steroids trigger oocyte maturation in several different …
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Multiscale Monte Carlo study of epidermal growth factor receptor diffusion and dimerization
The ErbB family of receptors is dysregulated in a number of cancers, and the signaling pathway of this receptor family is a critical target for several anti-cancer drugs. Therefore, a detailed understanding of the mechanisms of receptors activation is critical. However, despite a plethora of …
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Drug-encapsulating EGF-sensitive liposomes for EGF-overexpressing cancer therapies
… in the treatment of epidermal growth factor (EGF)-overexpressing cancers due to the potential advantages, relative to current clinical therapies (generally limited to surgery, radiation therapy, traditional chemotherapy, and EGF receptor inhibitors (EGFRIs)), of using such 'smart' targeted …
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Targeting The Dimerization Of ERBB Receptor Tyrosine Kinases
The epidermal growth factor receptor: EGFR) is a membrane receptor tyrosine kinase whose over-activation has been implicated to cause many human cancers. Novel strategies to inhibit the activation of EGF receptors other than the conventional antibody-based and tyrosine kinase inhibitors are …
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Growth-factor-induced mitogenesis: Trafficking determinants of the cellular response
… binding event between the growth factor and its receptor. However, the dynamics of the cellular trafficking of growth factors and their receptors can be an important determinant of the cellular response to growth factor stimulation. We have explored this hypothesis using the epidermal growth …
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A Phenotypic And Genetic Characterization Of The Cell Adhesion Molecules Echinoid And Friend-Of-Echinoid In The Directed Cell Movements Of Ommatidial Rotation During Drosophila Eye Development.
… and <italic>fred</italic> in photoreceptors R1, R6, R7 and the cone cells for proper ommatidial rotation. In addition, I used a genetic approach to identify potential interactors of ed and fred in rotation, and found that both genes interact with two downstream effectors of Egf …
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Localized HB-EGF signaling and Connexin43 decrease in the myocardium
… transactivation of the epidermal growth factor (EGF) receptor by heparin-binding EGF (HB-EGF). Here it is shown that HB-EGF operates in a spatially restricted local circuit in the extracellular space within the myocardium, revealing the critical nature of the local microenvironment in …
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Quantitative analysis of the EGFRvIII mutant receptor signaling networks in Glioblastoma
… despite multimodal intensive treatment regimens. EGFRvIII is a truncated extracellular mutant of the EGF receptor (EGFR) that is commonly found in GBMs and confers tumorigenic behavior. Although much work has been done over the past decade to elucidate pathways involved in EGFRvIII receptor …
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New protein engineering approaches for potentiating and studying antibody-based EGFR antagonism
… by the over-expression and over-activity of the EGF receptor (EGFR), rendering this protein an attractive therapeutic target. Anti-EGFR therapeutics are a mainstay of clinical practice for the treatment of colorectal, lung and head and neck cancers but efficacy is limited and response rates low. …
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EGFR signaling regulates synaptic connectivity via Gurken
… understood. I describe a role for the EGF receptor and its ligand Gurken in target selection of octopaminergic Type II neurons in the Drosophila neuromuscular system. Mutants in happyhour, a regulator of EGFR signaling, form ectopic Type II neuromuscular junctions. These ectopic …
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Notch Signaling in Human Neuroblastoma Cells
… cascade. Aberrant signaling through the EGF receptor is involved in the genesis of some human cancers. Several reports have shown cross talk between EGFR signaling and the Notch cascade. We show here that the Notch target Hes-1 can be directly regulated by Ras/MAPK signaling at both …
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The receptor tyrosine phosphatase Ptp69D and the receptor tyrosine kinase Pvr in Drosophila nervous system development
… cytoskeleton. I have examined the roles of two receptors that are involved in axon guidance and cell migration in Drosophila. Ptp69D is a receptor tyrosine phosphatase required for axon guidance in the developing embryo and for layer-specific axon targeting in the developing visual system. Using …
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