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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 251 for “"EGF"”.

  1. Drug-encapsulating EGF-sensitive liposomes for EGF-overexpressing cancer therapies

    Wong, Albert, S.M. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2009

    … in the treatment of epidermal growth factor (EGF)-overexpressing cancers due to the potential advantages, relative to current clinical therapies (generally limited to surgery, radiation therapy, traditional chemotherapy, and EGF receptor inhibitors (EGFRIs)), of using such 'smart' targeted …

    mit Repository record

  2. Untersuchungen zum Mechanismus der PKD-vermittelten EGF Rezeptor-Transmodulation

    Besir, ChristinaLudwig-Maximilians-Universität

    … ersten Mal die PKC-vermittelte Inhibition der EGF-induzierten JNK-Aktivität durch GPCRn gezeigt, die durch Transmodulation des EGF Rezeptors verursacht wird. Darüber hinaus wurde anhand einer dominant negativen Mutante der Effekt von PKD auf diesen Prozess nachgewiesen und ihre Rolle in der …

    lmu-germany Repository record

  3. Characterization of Ligand-Induced Conformational Changes in the EGF Receptor

    Yang, Katherine2013

    … of ligand-induced conformational changes in the EGF receptor by Katherine S. Yang Doctor of Philosophy in Biochemistry Washington University in St. Louis, 2009 Professor Linda Pike, Chairperson The epidermal growth factor: EGF) receptor is a classical receptor tyrosine kinase that mediates …

    wustl Repository record

  4. Quantitative cue-signal-response analysis of EGF-induced cell migration

    Harms, Brian David, 1976-Massachusetts Institute of Technology2004

    … the phenomenological structure of CHO-EGFR cell paths using turn angle distribution and time series analyses. Increased local cell speed correlated with increased likelihood of local directional persistence, a result independent of biochemical modulation of overall cell motility. …

    mit Repository record

  5. Localized HB-EGF signaling and Connexin43 decrease in the myocardium

    Prince, Robin NeelyMassachusetts Institute of Technology2005

    … transactivation of the epidermal growth factor (EGF) receptor by heparin-binding EGF (HB-EGF). Here it is shown that HB-EGF operates in a spatially restricted local circuit in the extracellular space within the myocardium, revealing the critical nature of the local microenvironment in …

    mit Repository record

  6. The Significance of FRS2 Phosphorylation in EGF- and FGF-Induced Signaling

    Wu, YingjieLudwig-Maximilians-Universität

    lmu-germany Repository record

  7. Role of the interaction of proHB-EGF with heparan sulfate proteoglycans

    Prince, Robin NeelyMassachusetts Institute of Technology2009

    … epidermal growth factor-like growth factor (HB-EGF) exhibits activity as a juxtacrine, paracrine, and autocrine ligand for the epidermal growth factor receptor (EGFR), and possesses the ability to bind heparan sulfate proteoglycans (HSPGs). The interaction of HB-EGF with HSPGs has been …

    mit Repository record

  8. Novel Anti-Cancer Agents Targeting Epidermal Growth Factor (EGF) Protein-Protein Interactions

    Yawson, EmmanuelState University of New York at Buffalo2019

    Ph.D.

    buffalo Repository record

  9. Structural Determinants in the folding of epidermal growth factor (EGF)-Like domains

    NG AH SOCK ANGIE2011

    The epidermal growth factor (EGF)-like domain is an evolutionarily conserved modular protein subunit. Despite hypervariability of amino acid sequences in their inter-cysteine region, they preferentially fold into a three-looped conformation with a disulfide pairing of C₁-C₃, C₂-C₄, C₅-C₆. To …

    nus Repository record

  10. The 5' inositol phosphatase SHIP2 regulates EGF-elicited protrusion in MTLn3 cells

    Kuhlmann, Georgiana L. (Georgiana Louise)Massachusetts Institute of Technology2010

    … in membrane protrusion upon stimulation with EGF, and that recruitment of Mena to the leading edge is enhanced, implying that this increase in protrusion may be due to a change in Mena localization.

    mit Repository record

  11. Amphiregulin (areg) And Epidermal Growth Factor (egf): Disparate In Egfr Signaling And Trafficking

    Baillo, Andrea Jacqueline2011

    … human breast cancer cells require an AREG/EGFR autocrine loop for cell proliferation. We also demonstrated that AREG can increase EGFR stability and promote EGFR localization to the plasma membrane. In the presented dissertation we successfully knocked-down AREG expression in SUM-149 cells …

    wayne-thes Repository record

  12. EGF receptor-mediated fibroblast signaling and motility : role of nanoscale spatial ligand organization

    Richardson, Llewellyn B. (Llewellyn Bentley)Massachusetts Institute of Technology2006

    Cell motility is often governed by growth factor receptor and integrin adhesion receptor interactions with the extracellular environment followed by collaborative intracellular signaling. While integrin ligands are necessarily bound within the extracellular matrix to permit force transduction by …

    mit Repository record

  13. Breast Cancer Cells Acquire a Stem-Like Phenotype by TGFß1/EGF Induced Epithelial-Mesenchymal Transition

    Xiong, ChengkaiOhio University2013

    … factor (TGF)-ß and Epidermal Growth Factor (EGF) induces EMT and allows cancer cells to become more stem-like. We have shown that TGF-ß1 alone can partly increase expression of EMT-related transcription factors in BT-20 and MCF-7 cells. Furthermore, EGF alone can induce a stem cell-like …

    ohiolink Repository record

  14. Charakterisierung von Schlüsselproteinen der Signaltransduktion (EGF-R, c-erbB2, Hsp90) in humanen Tumorxenografts mittels Gewebemikroarray

    Schandelmaier, Kathrin

    … <br>Schlüsselproteine der Signaltransduktion (EGF-R, c-erbB2, Hsp90) wurden in dieser Arbeit untersucht. Überexpression dieser Proteine in Tumoren geht mit schlechter Prognose für die Patienten einher. EGF-R und c-erbB2 sind deshalb interessante Targets für neue molekulare Tumortherapien. …

    freiburg-diss Repository record

  15. EGF module-containing mucin-like hormone receptor 2 and its role in human immune privilege

    Song, Helen2014

    … of Epidermal growth factor-seven transmembrane (EGF-TM7) molecules, which include the EGF module-containing mucin-like hormone receptor (EMR) molecules. In the human, EMR1 has sequential homology with F4/80 and EMR2 has shown immune suppressing function in tumor cells. Thus, we investigate the …

    bu Repository record

  16. Klonierung und Charakterisierung von Rezeptorkinasen der EGF- und TGF-Beta-Familie des kleinen Fuchsbandwurmes Echinococcus multilocularis

    Kroner, AntjeUniversität Würzburg

    … wurden erstmals eine Rezeptor- Tyrosinkinase der EGF Familie, eine Serin- Threoninkinase der TGF- Familie sowie ein intrazellulärer Signaltransduktionsfaktor der Smad- Familie aus dem Fuchsbandwurm Echinococcus multilocularis charakterisiert. Mittels degenerativer PCR und 3´/ 5´-RACE Methoden …

    wurz-thes Repository record

  17. Quantitative analysis and modulation of the spatial operation of the EGF receptor autocrine cell signaling system

    DeWitt, Anne Elizabeth, 1974-Massachusetts Institute of Technology2001

    The spatial localization of EGFR autocrine systems is a critical factor for tissue development and homeostasis. It is difficult to analyze these systems, however, because they are both self-contained and recursive. To understand how cellular parameters influence autocrine activity, we investigated …

    mit Repository record

  18. The Role Of The Sparc Acidic Domain And Egf-Like Module In Glioma Migration, Invasion, And Signaling

    Mcclung, Heather M.2011

    <p>THE ROLE OF THE SPARC ACIDIC DOMAIN AND EGF-LIKE MODULE IN GLIOMA MIGRATION, INVASION, AND SIGNALING</p> <p>HEATHER M. MCCLUNG</p> <p>Advisor: Sandra A. Rempel, Ph.D.</p> <p>Major: Pharmacology</p> <p>Degree: Doctor of Philosophy</p> <p>We have previously shown that Secreted Protein Acidic and …

    wayne-thes Repository record

  19. Erforschung des Beitrags des MAPK- und STAT-Signalwegs an der EGF-vermittelten Aktivierung der c-fos-Gen-Expression

    Kindle, Karin

    … Epidermis-Wachstumsfaktor. Dieser bindet an den EGF-Rezeptor und durch diese Interaktion wird der äußere Reiz über verschiedene Signalwege in die Zelle übermittelt und in eine entsprechende Gen-Aktivierung umgesetzt. Der EGF-Rezeptor und das verwandte EGF-Rezeptor-Familien-Mitglied, der …

    freiburg-diss Repository record

  20. Expression of Epidermal Growth Factor Receptor in hypopharyngeal cancer and Effect of EGF in Progression of hypopharyngeal cancer

    김, 윤태2011

    "Background and Objectives: The EGFR is a member of the erbB family of receptor tyrosine kinase proteins, which also includes HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4). High levels of EGFR expression are correlated with poor prognosis and resistance to radiation therapy in a variety of …

    ajou Repository record

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