Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"EFFECTOR T CELLS"”.
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The role of JAK1 and JAK3 in CD8<sup>+</sup> effector T cells
… on interleukin-2 signalling in CD8<sup>+</sup> effector T lymphocytes. Initial experiments compared the effects of the pan JAK1/JAK3 inhibitor tofacitinib, the selective JAK1 inhibitor GSK186, and the selective JAK3 inhibitor GSK192 on IL-2 control of effector CD8+ cytotoxic T cells (CTL). On …
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The regulation and function of Forkhead box O transcription factors FOXO1 and FOXO3 in T and iNKT lymphocytes
… roles. In response to foreign antigens, naïve T cells activate expand and differentiate into effector T cells which mediate pathogen elimination. During the aftermath of pathogen clearance, a subset of effector T cells revert back to quiescence and differentiate into memory T cells. The Forkhead …
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Development and Characterization of A Bi-Specific Antibody Targeting Hla-A2/Pr1
… PR1/HLA-A2 on leukemia and CD3 on neighboring T cells. Here we demonstrate successful production and purification of the h8F4 bi-specific antibody. Utilizing flow cytometry, we confirm PR1/HLA-A2 and CD3-specific binding characteristics, T cell activation in the presence of PR1/HLA-A2, and …
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Role of Allergic Conjunctivitis in Inducing Corneal Transplant Rejection
… to the donor’s alloantigens. Regulatory T cells (Tregs) have also been shown to be important in corneal allograft survival. Our results indicated that allergic conjunctivitis altered the Tregs that support corneal allograft survival. Th2 cytokines, namely IL-4, generated during allergic …
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Ctla-4 transcriptional activation: regulation of induced expression
… interaction transmits a negative signal in T cells, leading to suppression of proliferation. CTLA-4 is constitutively expressed on regulatory T cells (Tregs) but is also inducible in effector T cells. The mechanisms driving transcriptional regulation of CTLA-4 are poorly understood. Our …
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Cd4 T Cell Activation And Ox40 Agonist Immunotherapy In Tuberculosis
… tuberculosis (Mtb) infection millions of effector T cells traffic to the lungs, but relatively few find antigen and become activated. We used an antigen receptor reporter mouse (Nur77-GFP) infected with Mtb to distinguish recently activated CD4 T cells from others in the lungs. Recently …
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Regulation of Dendritic cell function by the ocular microenvironment
… to the production and recruitment of pathogenic effector T cells to the eye. Using an in vitro model of DC function, I observed that non-inflammatory aqueous humour (AqH) inhibited DC maturation, with reduced MHC and CD86 expression, and reduced capacity to induce proliferation of allogeneic T …
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Pathogenesis of the carcinogenic bacterium, Helicobacter pylori
… model, adoptive transfer of wildtype (wt) effector T cells (TE) into H. pylori-infected lymphopenic Rag2-/- recipient mice resulted in H. pylori-associated corpus gastritis superimposed with non-specific gastroduodenitis. Cotransfer with TE and regulatory T cells (TR) from wt or IL10-/- …
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Efficacy and Mechanism of Â-Defensin2 Fused Antigen Protein Vaccines
… IFN-ã release levels by antigen specific effector T cells when antigen is crosspresented by dendritic cells (DC) which absorbed mBD2 vaccine (mBD2 fused antigen protein) over antigen alone. We move unto an in vivo model and note significant increases in the expansion of antigen specific …
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Potentiation of The Immune Checkpoint Blockade Response By Metabolic Modulation Is Predictable Using Molecular Imaging
… of cancer. The high metabolic needs of the tumor cells result in nutrient depletion and produce a hostile tumor microenvironment (TME) for antitumor immune cells, protecting the tumor from immune cell-mediated control and immunotherapy. Two of these environmental factors, acidosis and hypoxia, are …
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Role of the CTLA-4 receptor in regulatory T cell development, homeostasis and function
… arthritis and multiple sclerosis. Regulatory T cells (Tregs) are a subset of CD4+ T cells that express the lineage-specific transcription factor Foxp3 and exert dominant peripheral tolerance to maintain immune homeostasis. It is therefore important to fully understand the underlying mechanisms …
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BOTH EFFECTOR AND INHIBITORY IMMUNE MECHANISMS ARE AMPLIFIED IN CASTRATION-RESISTANT PROSTATE CANCER
… In this dissertation, we show that both effector and inhibitory immune mechanisms are amplified by androgen ablation. In chapter II, we showed that CD8+ T cell responses to a model tumor antigen were transiently enhanced after castration in a prostate tumor model. We also observed a …
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Glucocorticosteroid modification of lymphocyte blastogenesis in fibrosarcoma-bearing mice
… lymphocyte proliferation were assessed. T cells from nontumor-bearing mice showed a 2-fold suppression of phytohemagglutinin (PHA) responsiveness with the addition of 0.1 µg HCS. However, T cells from mice with 3-4 week tumors did not demonstrate as great a suppression, if any. Kinetic …
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EPAC1 AS A THERAPEUTIC TARGET FOR PANCREATIC DUCTAL ADENOCARCINOMA
… modulation of the activity of regulatory T-cells (Treg), a subset of T-cells that suppress the immune system and maintain immune tolerance. In three common PDA cell lines, AsPC-1, PANC-1, and MIA PaCa-2, suppression/inhibition of EPAC1 reduced invasion/migration in transwell …
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Modulation of Pi3K-Akt Pathway In Colorectal Cancer
… we found increased densities of effector T cells and increased expression of several checkpoints (including PD-L1) at the center of PI3K-altered early-stage MSS CRC. Subgroup analysis showed increased CD8+ cells among <em>PIK3CA</em><sup>mut</sup> but not PTEN<sup>loss</sup> …
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The Role of TCR Engagement Strength in Antitumor CD8 T Cell Exhaustion
… by the persistence of progenitor exhausted CD8 T cells (Tpex). Tpex serve as a source for the pool of effector T cells that tend to have a short lifespan or eventually become dysfunctional in uncleared tumors. In contrast to the short-lived feature of their daughter cells, Tpex are able to …
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Variations in Antigen Presentation Define Regulatory T Cell formation and Activity in Vivo
… and activity of Foxp3+ regulatory T (Treg) cells can be affected by variations in the amount of a cognate antigen (Ag) that is present, the cell types by which it is expressed and/or presented, and whether Ag recognition occurs in an inflammatory environment. Recognition of a weakly …
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Cell Biology of Foxp3+ Regulatory T Cells
<p>T cells play a central role in the immune response to fight against pathogens and orchestrate other immune cells. An overreactive immune response can lead to autoimmune diseases, therefore the immune system must possess negative regulation mechanisms. In the periphery, naturally arising …
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Chemokinrezeptorexpression auf T-Zellen in bronchoalveolärer Lavage und peripherem Blut bei Kindern mit chronischer Bronchitis und interstitiellen Lungenerkrankungen
… receptors are differentially expressed on effector T cells. We hypothesized that selected T cells accumulate in inflammatory lung diseases involving different pulmonary compartments. To test this hypothesis the frequencies of chemokine receptor expressing T cells were compared in peripheral …
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Role and specificity of regulatory T cells during retroviral infection
… persistent infection of hematopoietic cells. The results obtained suggested that unregulated CD4+ T cell response to FV causes bone marrow pathology and anaemia. Regulatory T (Treg) cells are a subset of CD4+ T cells which have been shown to suppress immune responses and to have …
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