Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 11 of 11 for “"ECM remodelling"”.
-
INTEGRATED MOLECULAR INVESTIGATIONS OF MYRF AND SFRP2: UNVEILING REGULATORY MECHANISMS OF ER STRESS AND ECM REMODELLING IN PANCREATIC CANCER
… to contribute to the extracellular matrix (ECM) remodeling: we observed that SFRP2 led to a noteworthy augmentation in this process, along with increased migratory and invasive capabilities of PDAC cells. We also demonstrated that the abundance of ECM components contributes to different …
-
Bridging the lesioned spinal cord using hydrogel
… activation 4 week after injection 14 3. Remodelling of extracellular matrix by I-5 injection 16 4. Matrixmetallo-proteinase-9 ( MMP-9) involved in ECM remodelling 20 5. Perivascular fibroblasts are a major source of the newly formed ECM at 1 and 4 week 23 6. I-5 injection promotes …
-
Targeting macrophages GLP-1 receptor pathways as emerging therapies to ameliorate cardiac remodelling associated with diabetes
… with inflammation, extracellular matrix (ECM) changes, and diastolic dysfunction, which accelerate heart failure development and progression. Despite active control of blood glucose and cardiovascular risk factors, macrovascular complications remain the main cause death in type 2 diabetes. …
-
The ageing hair follicle environment. Alterations in the female scalp and mesenchyme with age.
… suggests altered extracellular matrix (ECM) remodelling due to increased levels of MMP-2 and Protease inhibitor Plasminogen activator inhibitor-1 (Serpin E1/PAI-1). Cathepsin C/DPPI protein lysate expression decreased in DFs but increased in DS. In summary, ageing female scalp shows …
-
Aberrant expression of mir-133a alters the expression of key inflammatory genes in the endothelium
… expression under TNF-α stimulation, supporting ECM remodelling, while miR-133a-3p also induced ICAM-1 expression in response to TNF-α, enhancing leukocyte adhesion. Conclusion: miR-133a regulates endothelial responses during inflammation. The distinct effects of its 3p and 5p strands on …
-
Targeting LGALS3 to treat steatotic liver disease and hepatocarcinogenesis
… secrete large amount of extracellular matrix (ECM) proteins. ECM remodelling towards a fibrotic phenotype represents an important risk factor for hepatocellular carcinoma (HCC), which incidence and mortality have been continuously increasing, and, unfortunately, the approved pharmacological …
-
ADAMTS1 is a promoter of metastatic cell behaviour in mammary cancer cells.
… and invasiveness. The extracellular matrix (ECM) environment plays a vital role in the processes involved in metastatic progression and undergoes aberrant remodelling to permit and support the metastatic cascade. Metalloproteinases are a group of enzymes that play a major role in ECM …
-
Role of peritoneal mesothelial cells and the inflammatory response in peritoneal fibrosis
… cells, cell proliferation, extracellular matrix (ECM) deposition and remodelling, often with overlap between phases. The unique feature of peritoneal repair is that both small and large peritoneal wounds heal in a similar time. The peritoneum is a monolayer of elongated, flattened, squamous-like …
-
Untersuchungen zur Pathobiochemie der extrazellulären Matrix bei Pseudoxanthoma elasticum (PXE)
… disorder that is characterized by extensive remodelling of the extracellular matrix (ECM). PXE is caused by mutations in the ABCC6 gene. By now, no conclusive pathophysiological connection between ABCC6 and the clinical findings of the disease could be established. Particularly, the molecular …
-
Characterising embryonic stem cell-derived tenocytes and determining the changing role of scleraxis during tendon development
… an overrepresentation of extracellular matrix (ECM) remodelling processes within both comparisons. These included several matrix metalloproteinases, proteoglycans and collagens, some of which were also investigated in SCX knockdown tenocytes from young postnatal foals. Using chromatin …
-
The Contribution of Environmental Cues to Early Squamous Tumour Formation in the Upper Gastrointestinal Tract
… in processes such as cell proliferation, ECM remodelling, and wound healing. Notably, in vitro experiments revealed that FINC and AREG promoted epithelial cell proliferation and migration, respectively, highlighting the potential role of tumour-associated ligands in altering epithelial …