Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"ECM remodeling"”.
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The impact of diet-induced obesity and exercise on adipose-resident stem cells
… tissue that can influence extracellular matrix (ECM) remodeling during lipid filling and adipose expansion. Both mesenchymal stem cells (referred to as adipose-derived stromal cells, or ADSCs) and pericytes may secrete factors such as collagen and metalloproteinases that can allow for tissue …
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Biomechanical and Molecular Approaches to Aortic Valve Disease in a Mouse Model
… activation and abnormal extracellular matrix (ECM) remodeling are hallmark features of AVD. Elastin is one of the primary ECM proteins in the aortic valve and is responsible for valve extension and recoil. Mutations or deletions in the elastin gene cause elastin haploinsufficiency, a clinical …
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Determining if the Developmental Origin of Cardiac Fibroblasts Determines the Fate of Activation in Adult-Onset Hypertension
… characterized by excessive extracellular matrix (ECM) deposition and tissue stiffening, impairs cardiac function, reducing contractility and increasing the risk of arrhythmias [13, 17]. Resident cardiac fibroblasts, originating from epicardial and endothelial progenitors, are essential regulators …
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Adipose Tissue And Its Role In Modulating The Mammary Tumor Microenvironment
… possibly partake in extracellular matrix (ECM) remodeling and blood vessel recruitment. Both tumor-associated ECM remodeling and neovascularization are typically mediated by myofibroblasts, which are known to be recruited or differentiated from other stromal cells. However, whether …
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Investigating the Molecular Mechanisms of SNED1 Fiber Assembly in the Extracellular Matrix
The extracellular matrix (ECM) is a complex scaffold of 150+ proteins that modulates all cellular functions and is critical for pathophysiological processes including cancer, and fibrosis. Our laboratory is interested in studying a novel ECM protein called SNED1 that Dr. Naba initially identified …
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ALLOGRAFT DERIVED BIOSCAFFOLDS FOR TISSUE ENGINEERING OF THE MENISCUS: AN IN VIVO OVINE STUDY AND THE EFFECT OF HYPOXIC CULTURE ON SEEDED MENISCUS CONSTRUCTS
… proteoglycan staining and extra cellular matrix (ECM) remodeling was observed in the area of tissue healing. In addition, this work demonstrated the use of an in vitro three-dimensional culture system for the attachment and migration of cells for differentiation under normal culture conditions.
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An immune-competent microvascularized human lung-on-chip device for studying immunopathologies of the lung
… in significant lymphopenia, extracellular matrix remodeling, and transcriptional shutdown in fully immune-competent lung tissues. Lastly, we highlight the prominent role of stromal-immune interactions in the response to severe influenza infection, with stromal cells participating in both cytokine …
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Relevanz der humanen Xylosyltransferase-I in der Seneszenz-assoziierten Gewebe-Remodellierung und der adulten Knochenhomöostase
… significantly involved in extracellular matrix (ECM) remodeling by catalyzing the initial step of proteoglycan (PG) biosynthesis. Aberrant XT-I gene expression and activity is associated with age-associated diseases such as fibrosis or osteoarthritis, but also with the occurrence of skeletal …
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Artificial neural network models utilize chamber-specific predictors of cardiac fibrosis in ovariectomized and aortic-banded Yucatan mini-swine
… role in the manifestation of disease. Fibrotic remodeling quantified in this project occurs in a chamber-dependent manner on both sides of the heart. Extracellular matrix (ECM) remodeling is the core of this pathological process. The prevalence of HFpEF is greater in postmenopausal women with …
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Development of a pericyte-derived extracellular vesicle therapy for the recovery of skeletal muscle mass following immobilization
… myogenesis and extracellular matrix (ECM) remodeling. Pericyte intramuscular transplantation concurrent with 4 weeks of electrical stimulation significantly increased collagen remodeling and muscle capillarization. Lastly, intramuscular transplantation of plasma-derived CD146+ EVs …
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Stromal Fibroblasts Restrain The Rate of Colon Cancer Progression and Metastasis By Suppressing Regulatory T Cells and Colon Cancer Stem Cells
… cells, and extracellular matrix components (ECM). Fibroblasts are ubiquitous stromal cells that can influence other neighboring cell types through the secretion of chemokines, cytokines, ECM, ECM remodeling enzymes, and other metabolites. Myofibroblasts are a distinct subtype of fibroblasts …
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Mechanical Deformation of the Extracellular Matrix Mediates Cellular Activation and Mechanotransduction
… applied to the cardiac extracellular matrix (ECM) at the cellular level (i.e. myocyte contraction and/or fibroblast focal adhesions) or globally through hemodynamic pressures. While mechanical load can be an important factor in maintaining tissue homeostasis, little is known about how …
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Cd44-Mediated Collagen Remodeling Drives Wound Resolution And Pancreatic Tumorigenesis
… stromal cells, and extracellular matrix (ECM) remodeling. Deregulation of these processes, resulting in chronic inflammation or aberrant accumulation of ECM components, such as fibrillar collagen or hyaluronic acid (HA), contributes to exacerbated scar formation and promotes tumorigenesis. …
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Effects of Mechanical Forces on the Biological Properties of Porcine Aortic Valve Leaflets
… that cathepsins might be involved in valvular ECM remodeling.
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Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-Mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
An extracellular matrix (ECM) rich in fibrillar collagens is a principal component of pancreatic ductal adenocarcinoma (PDA). The ECM provides structural support for the tumor and facilitates tumor cell survival and chemoresistance by activating cell surface receptors on tumor cells. Fibrillar …
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Mechanism of local IL-6 production and its role in accelerating vascular inflammation leading to aortic diseases
… thereby accelerating vascular inflammation, ECM remodeling and aortic destabilization.
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Functional Heterogeneity of Fibroblasts In Dermal Wound Healing
… contractile properties and extracellular matrix (ECM) remodeling functions to promote effective tissue repair. Dermal fibroblasts are also postulated to orchestrate tissue repair by interacting with and controlling other cell types in the wound microenvironment. It has become increasingly clear …
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Targeted Inactivation of APE1 Endonuclease by E96A Mutation Sensitizes Pancreatic Ductal Adenocarcinoma to DNA-Damagin Therapy
… of genes involved in extracellular matrix (ECM) remodeling and cell adhesion consistent with a less aggressive phenotype. In vivo, orthotopic mouse models demonstrated that APE1 E96A cells formed significantly smaller tumors and exhibited reduced metastasis, even in the absence of treatment. …
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The role of extracellular matrix remodelling in brown adipose tissue functions: New candidates
… and functionality of the extracellular matrix (ECM). However, the main obstacle is that obese and diabetic patients have less active BAT mass. Understanding the mechanisms that regulate and impair BAT activity in obesity is essential for developing an efficient strategy to increase BAT mass and …
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Determining Mechanisms by which Pathological Extracellular Matrix induces Ocular Hypertensive Phenotypes in Human Trabecular Meshwork Cells
Purpose: Aberrant extracellular matrix (ECM) remodeling is prevalent in several sight-threatening diseases; in the trabecular meshwork (TM), it is implicated in elevated intraocular pressure (IOP), the only treatable risk factor for glaucoma. Herein, two different glaucoma-relevant cell-derived …
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