Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 683 for “"ECM"”.
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Modeling and measurement of intermolecular interaction forces between cartilage ECM macromolecules
… that make up its extracellular matrix (ECM). Aggrecan is the most abundant proteoglycan in articular cartilage. It is composed of a core protein with highly charged, densely packed glycosaminoglycan (GAG) side chains, which are responsible for [approximately] 50% of the equilibrium …
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Single Cell Force Platforms to Link Force-ECM Coupling in Pathophysiology
… biophysical link in the remodeling of the ECM and perpetuation of desmoplasia. Using NFM, seven discreet steps in formation of force-exerting PLPs anywhere along the cell body is documented, which allow cells to spread laterally and increase in contractility. Using a variety of fiber …
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Application of Cell-Derived Extracellular Matrix (ECM) Scaffold on Tissue Engineering Cartilage
… of novel cell-derived extracellular matrix (ECM) scaffold on cartilage tissue engineering in vitro and in vivo as nude mouse and rabbit model. Chapter I: A porous cell-derived ECM scaffold was prepared with a freeze-drying protocol using porcine chondrocytes. The ECM scaffold had highly …
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Cellular mechanosensitivity in vitro: cell-ECM, cell-cell, and cell-material interactions
Made available in DSpace on 2015-09-29T21:02:41Z (GMT). No. of bitstreams: 2 ALI-DISSERTATION-2015.pdf: 4946984 bytes, checksum: 649de0269d74763792c883cf2346193d (MD5) LICENSE.txt: 4215 bytes, checksum: b416febe9eaf70ac46d72a4e366da385 (MD5) Previous issue date: 2015-05-13
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High Temperature SiC Embedded Chip Module (ECM) with Double-sided Metallization Structure
… in the form of an Embedded Chip Module (ECM) is proposed to realize a lower stress distribution in a mechanically balanced structure with double-sided metallization layers and material CTE match in the structure. Thermal and thermo-mechanical analysis on an ECM is then used to demonstrate …
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A Bottom-Up Assembly Of Vascularized Bioartificial Constructs Using Ecm Based Microscale Modules
… cell-cell interaction, extra cellular matrix (ECM) deposition and tissue level organization. Accomplishing these prerequisites with the currently available conventional scaffolds and fabrication techniques still remains a challenge. To reproduce the full functionality there is a need to …
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Microrna-200 Regulates Ecm-Dependent Β1-Integrin/Fak Signaling and Cancer Cell Invasion
… changes enhanced the cells responsiveness to the ECM through the FAK/Src pathway. The importance of this pathway in our Kras and p53 mouse model and in human lung cancer cell lines was further studied using pharmacological inhibitors and an shRNA-based knockdown approach, which exhibited a …
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Impact of the Tumor ECM Niche On AML Drug Sensitivity: A Comparative Screening Study
… leukemic cells and the extracellular matrix (ECM) within the bone marrow niche. These ECM-driven signals promote cell survival and reduce therapeutic sensitivity, contributing to treatment failure and relapse. Traditional two-dimensional polystyrene cultures do not recapitulate these …
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Interactions of Fibroblast with Cytotoxic and Invasive Strains of Pseudomonas aeruginosa on ECM Mimicking Fibers
… breaking down the damaged extracellular matrix (ECM) and secreting a new ECM which aids in wound repair and supports the migration of immune cells. Pseudomonas aeruginosa is an opportunistic pathogen commonly associated with health-care infections (HCAIs) due to its ability to take advantage of …
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The influence of ECM on mesenchymal stromal/stem cell activity and their interactions with monocytes/macrophages
… interactions and changing extracellular matrix (ECM) environment. This thesis aimed to extend the current understanding of the biology underpinning this process, focusing on the interaction between mesenchymal stromal/stem cells (MSCs) and monocytes/macrophages within dynamically changing ECM …
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Analisa indikator makro ekonomi terhadap pertumbuhan sukuk di Indonesia: Sebuah analisa dengan metode Error Correction Model (ECM)
… panjang dan jangka pendek. Hasil pengujian ECM menunjukkan bahwa dalam jangka panjang variabel pertumbuhan ekonomi berpengaruh signifikan jangka panjang terhadap pertumbuhan sukuk korporasi sebesar 1.363675. Inflasi memiliki pengaruh signifikan negatif terhadap pertumbuhan sukuk sebesar …
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Understanding the achievement of benefits through use of Enterprise Content Management (ECM) systems in public sector organisations
… implementing the Enterprise Content Management (ECM) system because of their large volume of unstructured content which led to documents being stored in various repositories. This made it difficult for such organisations to access, control and locate documents. ECM systems are therefore …
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Untersuchungen zu Auswirkungen von GAG-Linkeropathien auf die ECM-Homöstase durch die Generierung von knockout-Modellen in Dermalfibroblasten
… Bestandteile der extrazellulären Matrix (ECM) von Zellen und werden durch die kovalente Bindung von Glykosaminoglykanen (GAG) an ihre core-Proteine gebildet. Der Tetrasaccharid-Linker bildet das Bindeglied zwischen dem core-Protein des PGs und der repetitiven Disaccharidkette des GAGs und …
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INTEGRATED MOLECULAR INVESTIGATIONS OF MYRF AND SFRP2: UNVEILING REGULATORY MECHANISMS OF ER STRESS AND ECM REMODELLING IN PANCREATIC CANCER
… to contribute to the extracellular matrix (ECM) remodeling: we observed that SFRP2 led to a noteworthy augmentation in this process, along with increased migratory and invasive capabilities of PDAC cells. We also demonstrated that the abundance of ECM components contributes to different …
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A Microfludic Assay Device for Study of Cell Migration on ECM-mimicking Suspended Nanofibers in Presence of Biochemical Cues
… embryogenesis. In vivo, cells migrate on fibrous ECM, but chemotaxis studies are typically conducted on flat substrates which fail to recapitulate ECM or 3D gel environments with heterogeneous and poorly defined biophysical properties. To address these challenges, this thesis focused on developing …
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Angiogenic growth factors and notch signaling regulate liver sinusoidal endothelial cell phenotype in combination with matrix stiffness and ECM composition
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
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Cue, signal, response analysis of murine embryonic stem cell differentiation : multivariable analysis of cytokine and ECM effects on commitment to differentiation
The highly complex nature of developmental cell fate decisions is exemplified by murine embryonic stem cell (ES cell) differentiation, for which almost two decades of study has identified a small set of putative individual molecular cues which are difficult to generalize broadly or discern …
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