Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"ECFCs"”.
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¿ROLE OF ENDOTHELIAL DYSFUNCTION IN THE PATHOGENESIS OF UNPROVOKED VENOUS THROMBOEMBOLISM¿
… endothelial colony-forming cells (ECFCs) that represent an optimal non-invasive model to assess the functionality of the endothelial compartment. In particular, in this project we aimed to: • set-up and optimize ECFC-based functional assays aimed at assessing thrombogenic …
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Potential of endothelial progenitors to reverse choroidal atrophy during age related macular degeneration
Pre-clinically ECFCs have already demonstrated a high potential for revascularisation in a number of models, this makes them an attractive candidate for a number of conditions where impaired blood flow is a factor affecting recovery. However, it is still important to consider the pathology that …
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Rapid formation of cell-mediated microvascular networks in collagen, fibrin, and puramatrix provisional matrices
… in which human endothelial colony-forming cells (ECFCs) and mesenchymal progenitor cells (MPCs), coinjected with a solubilized extracellular matrix (ECM), rapidly form perfused blood vessel networks in mice. This dissertation demonstrates that ECFCs and MPCs formed vessels in a variety of ECM …
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Understanding the Role of von Willebrand Factor (VWF) in Angiogenesis and Angiodysplasia
… can correct aberrant vessel formation. In vitro, ECFCs derived from Type 2A and Type 3 VWD patients, as well as an individual with AVWS from aortic stenosis, exhibited impaired adhesion, proliferation and migration, together with abnormal angiopoetin-2 (Ang-2) trafficking. siRNA-mediated VWF …
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Pathogenicity assessment of genetic variants in von Willebrand disease using quantitative, qualitative, and functional approaches
… endothelial colony forming cells (ECFCs) revealed that c.8155+6T>A resulted in VWF that was mostly retained in a perinuclear position as opposed to being packed into Weibel-Palade bodies (WPBs). In order to overcome the finite supply of ECFCs and assess the effect of c.8155+6T>A in …
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Vasogenic bloodborne progenitors and diabetes
… macrophages. Endothelial Colony Forming Cells (ECFCs) are the de facto endothelial progenitor, contributing directly to vascular repair.<br/><br/>In this PhD project, it was hypothesised that all three classes of EPCs are altered in the context of diabetes. EPCs from patients with diabetes have …
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Evaluación del potencial terapéutico de diferentes combinaciones celulares para promover la regeneración vascular en un modelo murino de isquemia crítica que amenaza la extremidad
… por células endoteliales formadoras de colonias (ECFCs) aisladas de tejido adiposo o cordón umbilical, combinadas con células madre mesenquimales (MSCs). En general, la implantación de los diferentes productos celulares mejoró la recuperación del flujo sanguíneo tras la lesión isquémica a través …
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Characterisation of endothelial cell metabolic plasticity and vascular remodelling in the retina
Diabetic retinopathy (DR) is the most frequently occurring microvascular complication of diabetes mellitus, where the later stages of the disease are often is chaemia driven which can result in severe vision loss. A key component cell of the retinal neurovascular unit is the vascular endothelium, …