Global ETD Search
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Showing 1 to 8 of 8 for “"EC50 value"”.
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QUB-1383, a novel bioactive peptide from the defensive skin secretion of the edible frog (Pelophylax kl. esculentus)
… relatively strong haemolytic activity with EC50 value at 39.64 μM. QUB-1383 also exerted weak inhibitory effect to trypsin, with a Ki value of 20.74 ± 6.87 μM. <br/>Due to the potent antimicrobial activity of QUB-1383, this peptide could be considered as a candidate of novel antibiotics …
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Structure-Activity Relationship Studies of Mitochondrial Uncouplers and PilB Inhibitors
… models. Our previous work identified BAM15 (EC50 1.5 M) as a potent and efficacious mitochondrial uncoupler with potential for obesity treatment. In this study, we investigate in vitro and in vivo properties of hydroxylamine and hydrazine BAM15 derivatives and reveal the high uncoupling …
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URSOLIC ACID INHIBITED PROLIFERATION AND INVASION OF MDA-MB-231 HUMAN BREAST CANCER CELLS VIA REGULATING CELLULAR SIGNAL TRANSDUCTION PATHWAYS
… at the concentrations without cytotoxicity. The EC50 value of anti-proliferative activity was 30.67 µM. UA at concentrations of 20, 30, and 40 µM significantly inhibited cell invasion. Additional tests associated anti-invasion activity of UA with antagonizing the stimulation of EGF. UA affected 8 …
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Design, Synthesis, and Structure-Activity Relationship Investigation of Selective Sphingosine Kinase Inhibitors
… evaluated in a yeast cell assay to determine EC50 values. The U937 cell line and mice model were utilized for hit compounds to quantify S1P reduction in vitro and in vivo. Our preliminary results indicated compound 2.14d was the best hit discovered, with 88% SphK1 inhibition at 1 μM. In …
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The use of lipid profiles from immobilised selenastrum capricornutum in the biological surveillance of freshwaters
… 20 pM Zn and 5.7 pM Cd respectively. The Cu 24 EC50 value for immobilised cells was also shown to be 124 j.tM, suggesting that Cu exhibits similar toxic effects on growth in both free and immobilised cells. Studies of the effects of temperature and heavy metal exposure (Cu21, Zn 2 and Cd2 +) on …
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Phytophthora nicotianae: Fungicide Sensitivity, Fitness, and Molecular Markers
… were highly resistant to mefenoxam with a mean EC50 value of 326.5 µg/ml while the remaining 70 were sensitive with an EC50 of <0.01 µg/ml (Label rate: 0.08µg/ml). All resistant isolates were recovered from herbaceous annuals and irrigation water in 3 Virginia nurseries. Resistant isolates were …
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Evaluation of race population distribution, fungicide sensitivity, and fungicide control of Exserohilum turcicum, the causal agent of northern leaf blight of corn
… at which 50% of the fungal growth was inhibited (EC50) for each isolate-fungicide combination. Baseline EC50 value lsmeans for metconazole, propiconazole, and prothioconazole were 0.032 µg/ml, 0.060 µg/ml, and 0.254 µg/ml, respectively. When lsmeans of EC50 values for 2009, 2010, 2011, 2012, 2013, …
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Putative phosphodiesterase inhibitors as potential new chemotherapies against African Trypanosomiasis
… reduction assay. 25 compounds from Series 1 had EC50 values below 0.5 µM, with 7 under 100 nM and the most active having an EC50 value of 5.8 ± 3.4 nM. For the much smaller Series 2 (GJS Compounds), the most active compound was GJS-128 with an EC50 value of 79.4 ± 10.3 nM. This demonstrates that …