Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 97 for “"EBV"”.
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Ο ρόλος του ιού Epstein Barr (EBV) στη λεμφοματογένεση
… σειρά λεμφωμάτων που σχετίζονται με τον EBV, το καθένα ακολουθώντας μια μοναδική παθογενετική οδό, αποδίδεται κυρίως στην ύπαρξη ενός ενεργού ιικού γονιδιώματος σε κάθε μεμονωμένο καρκινικό κύτταρο. Όταν ένας τύπος όγκου μπορεί να αναπτυχθεί τόσο σε EBV-αρνητικές όσο και σε EBV-θετικές …
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Temporal Regulation of LMP1 and Apoptosis Resistance After Primary EBV Infection
<p>Epstein-Barr virus (EBV) is a ubiquitous human pathogen that establishes a lifelong latent infection in over ninety percent of all adult humans worldwide. While typically benign, EBV has been causally associated with a number of human malignancies in the settings of immune suppression, genetic, …
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EBV-Associated Gastric Cancer: From Initial Infection to Unique Therapeutic Approaches
<p>Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that infects over 95% of the adult population. While infection is typically asymptomatic, in some individuals, particularly the immunocompromised, EBV is the causative agent of several cancers including lymphomas and epithelial cancers. …
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Tengist mannanbindilektín skortur alvarlegum Epstein-Barr sýkingum? MBL magnmæling á sermi EBV sjúklinga
… sem orsakast af Epstein-Barr veirunni (EBV). Sjúkdómurinn kemur helst fram hjá unglingum og ungu fólki. Hjá börnum er sýkingin oft einkennalaus en getur komið harkalega fram hjá ungu fólki. Hluti sjúklinga sem fær einkenni einkirningasóttar þarfnast sjúkrahúsinnlagnar. Tilfellunum getur …
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Entwicklung von GM-CSF-produzierenden EBV-Vektoren für die Immuntherapie der B-CLL
… Behandlungsmethode dar. Epstein Barr-Virus (EBV) etabliert eine latente Infektion in der Zielzelle, in der das EBV-Genom extrachromosomal aufrecht erhalten wird. EBV eignet sich mit diesen Eigenschaften hervorragend als Genvektor. Meine Aufgabenstellung war es, neue EBV-abgeleitete …
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Control of the EBV growth transformation programme: the importance of the Bamhi W repeats
Epstein-Barr virus (EBV), a human gammaherpesvirus, possesses a unique set of latent genes whose constitutive expression in B cells leads to cell growth transformation. The initiation of this B-cell growth transformation programme depends on the activation of a viral promoter, Wp, present in each …
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CHARACTERIZATION OF HUMORAL RESPONSE TO EPSTEIN-BARR VIRUS (EBV) INFECTION AND PROTEIN KINASES INVOLVED IN VIRAL REPLICATION
Epstein-Barr virus (EBV) is a human herpesvirus that infects more than 95% of the world’s population by adulthood. Like other herpesviruses, EBV has a biphasic infection cycle which includes latent and lytic programs. Upon primary infection, the virus establishes a lifelong latency in memory B …
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EBV BART MicroRNAs Target Pro-apoptotic and Anti-Wnt Signaling Genes to Promote Cell Survival and Proliferation
<p>Epstein-Barr virus (EBV) is a ubiquitous human gamma-herpesvirus which chronically infects >95% of the global population, and can give rise to a number of malignancies in B cells and epithelial cells. In EBV latently infected epithelial cells, such as nasopharyngeal carcinoma (NPC) and gastric …
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Treatment outcomes of Epstein-Barr virus associated nasopharyngeal carcinoma with three-dimensional conformal radiotherapy: A retrospective review
… on treatment outcomes of Epstein-Barr virus (EBV) associated nasopharyngeal carcinoma (NPC) largely comes from endemic regions. There is limited literature available regarding the epidemiology and treatment outcomes of EBV associated NPC in South Africa. Aim: The primary aim of the study was …
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Of Mice and Men: Studying Innate and Adaptive Immunity Against the Epstein-Barr Virus
<p>The Epstein-Barr virus (EBV) is a lymphotropic γ-herpes virus infecting over 90% of the human adult population. A striking feature that the virus shares with other γ-herpes viruses is its oncogenic potential. This transforming property can be observed as B cell transformation in vitro and …
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Understanding the mechanism of antiretroviral nucleoside analogs as inhibitors of Epstein-Barr virus lytic DNA replication
Epstein-Barr virus (EBV) is a human B-cell tropic double-stranded DNA y-herpesvirus. To date, there are no antiviral agents proven to be clinically effective in the treatment of EBV infection or EBV-associated diseases. In the experiments contained in this thesis, we define the ability of …
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Humanized Mouse with a Diverse Polyclonal B Cell Repertoire as a Model for Neutralizing Antibody Responses against EBV and HIV
Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV) cause diseases of global health importance. However, it has been historically difficult to model human neutralizing B cell responses to these two viruses using small animals. I leveraged a transgenic mouse model that encodes a …
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The Effect of Modeled Microgravity and Radiation on Epstein-Barr Virus in a Modeled Spaceflight System
Epstein-Barr virus (EBV) is the causative agent of mononucleosis and is also associated with several malignancies, including Burkitt’s lymphoma, Hodgkin’s lymphoma, nasopharyngeal carcinoma, and post-transplant lymphoproliferative disorder, among others. EBV is known to reactivate during …
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Evaluation of the Role of Epstein-Barr virus and Cellular Gene Expression in Paediatric and Adult Transplant Recipients
… the early detection of PTLD. Epstein-Barr virus (EBV) infection is considered to be an important risk factor for PTLD. However, the correlations between EBV DNA loads and the onset of PTLD are inconclusive. The aim of this study was to identify potential biomarkers for the early onset of PTLD. To …
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The role of cellular micro-RNAs in Epstein-Barr virus induced cellular transformation and oncogenesis
… regulate gene expression. Epstein-Barr Virus (EBV) transforms resting B-cells in vitro to establish continuously proliferating lymphoblastoid cell lines (LCLs) and is aetiologically linked to lymphomas. Little is known about the contribution of miRNAs to the transformation of B cells. We …
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An investigation of the role of the Epstein-Barr virus-encoded protein, EBNA1, in the regulation of EBER expression
The Epstein-Barr virus (EBV)-encoded RNAs (EBERs) are abundantly expressed in all EBV-associated malignancies, although the precise mechanisms by which EBV is able to achieve such high levels of EBER expression have not been fully determined. Abundant EBER expression has previously been …
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An investigation of the epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal centre B cells
Although Epstein–Barr virus (EBV) usually establishes a harmless infection in human memory B cells, it is implicated in the development of germinal centre (GC) B-cell-derived malignancies, including Hodgkin’s lymphoma (HL). I have shown using gene expression profiling that lymphoblastoid cell lines …
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Funktion früher Gene des Epstein-Barr Virus bei der Immortalisierung humaner primärer B-Lymphozyten
… BALF1, BHRF1 und LMP2A von Epstein-Barr Virus (EBV) auf die B-Zell-Immortalisierung zu bestimmen. Diese EBV Mutanten bilden die Grundlage zur Funktionsanalyse der Genprodukte in infizierten humanen B-Zellen, die durch die Infektion mit EBV als stabile B-Zelllinien in vitro proliferieren und …
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An investigation of Epstein-Barr Virus (EBV) latency type and MYC gene aberrations in plasmablastic lymphoma diagnosed at Groote Schuur Hospital, Cape Town, South Africa
… however association with the Epstein-Barr virus (EBV) and the MYC gene, have been identified as important pathogenic mechanisms. Aims and objectives: To characterise the EBV latency in a cohort of patients diagnosed with PBL at Groote Schuur Hospital (GSH), by means of immunohistochemistry. To …
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