Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"EBNA1"”.
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Regulation of the Epstein-Barr virus C promoter by the OriP-EBNA1 complex
… cells express a repertoire of viral antigens (EBNA1-6 and LMP1), all of which have been directly implicated in the immortalization process. Immediately postinfection, EBNA2 and -5 are the expressed from the W promoter (Wp), within 36 hours there is a switch in promoter usage from Wp to the …
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An investigation of the role of the Epstein-Barr virus-encoded protein, EBNA1, in the regulation of EBER expression
… determining the role of EBV nuclear antigen 1 (EBNA1) in inducing changes to the cellular environment to allow high levels of EBER expression. EBNA1 was found to induce the transcription of cellular RNA polymerase (pol) II and pol III transcription factors associated with EBER expression and …
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Autophagy Delivers Viral Antigens for MHC Class II Presentation and is Regulated by Viral Infection
… using the Epstein- Barr virus nuclear antigen 1 (EBNA1) as a model antigen with relevance for human disease. We found that EBNA1 was degraded by lysosomal proteases and detected EBNA1 in double membrane structures by immuno-electron microscopy. Furthermore, inhibition of autophagy led to reduced …
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Ebna1-Specific T Cell Responses During Persistent Rhesus Lcv infection and The Development of a Novel Therapeutic Prototype Vaccine for Ebv-Associated Diseases
… available. The Epstein-Barr nuclear antigen 1 (EBNA1) is an important target for vaccination because it is the only protein expressed in all forms of latency and in all EBV-associated malignancies. The overarching goal throughout this dissertation was to determine if EBNA1 is a suitable target …
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CD4+ T cell recognition of Epstein-Barr virus nuclear antigen (EBNA) - 1 in the Chinese population
… antigen (EBNA) 1. CD4+ T cell response against EBNA1 has been studied in the Caucasian population, however, little is known about CD4+ T cell epitopes presented by HLA alleles in Chinese people. In this study, CD4+ T cell responses in 78 healthy Chinese EBV carriers were analyzed and found …
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Hepatitis B core (HBc) virus like particle (VLP) as a platform for innovation of chimeric adjuvant-free VLP vaccines targeting oncoviruses
… presenting Epstein–Barr virus nuclear antigen 1 (EBNA1) epitope (short and non-structural epitope) and Hepatitis C virus (HCV) core epitope (long and structural epitope) were successfully expressed and purified in the Escherichia coli (E. coli) expression system with high production yields, 62.1 …
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Ο ρόλος του ιού Epstein Barr (EBV) στη λεμφοματογένεση
… (EBV) συχνά περιορίζεται στην πρωτεΐνη EBNA1, η οποία είναι υπεύθυνη για τη διατήρηση του γονιδιώματος του ιού. Αυτό έχει ως αποτέλεσμα την υπερέκφραση δύο πρωτεϊνών, της c-MYC και της TCF3. Τα πειστικά στοιχεία δείχνουν ότι η λειτουργία του EBV είναι συμπληρωματική σε αυτές τις …
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An investigation of Epstein-Barr Virus (EBV) latency type and MYC gene aberrations in plasmablastic lymphoma diagnosed at Groote Schuur Hospital, Cape Town, South Africa
… monoclonal antibodies for EBV latent proteins, (EBNA1, EBNA2 and LMP1) was used to determine the latency type. Manual MYC FISH was performed on all PBL cases using a dual colour break apart rearrangement probe. Results: Forty-nine cases of PBL were included in this study. Forty-one cases were …
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Regulation des Zelloberflächenmoleküls CD83 durch das Epstein-Barr Virus und Analyse seiner Funktion
… 2 (LMP1 and LMP2) and the viral nuclear genes EBNA1, EBNA3A, -3B, -3C, EBNA-LP. Additionally EBNA2 is also able to transactivate cellular genes like CD21, CD23 or c-myc. To study the different EBNA2 target genes and the function of EBNA2 a LCL was established (ER/EB2-5 cells, Kempkes et al., …
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Stability Study of Engineered Ferritin Nano-vaccines by Combined Molecular simulation and Experiments
… human heavy-chain ferritin with a portion of EBNA1 inserted at the C-terminus. Four mutant ferritins with short C-terminal amino acid mutations and the letters C1 through C4 are used in this project. C1 was neutrally charged (Gln 167 and 171), C2 was positively charged (Arg 167 and 171), and …