Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"EAATs"”.
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… met by the excitatory amino acid transporters (EAATs). The presence of at least five isoforms of EAATs raises interesting questions as to potential structural and functional differences among the subtypes. We have investigated possible differences in the ligand binding domains of the EAATs …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… met by the excitatory amino acid transporters (EAATs). The presence of at least five isoforms of EAATs raises interesting questions as to potential structural and functional differences among the subtypes. We have investigated possible differences in the ligand binding domains of the EAATs …
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Equine-assisted activities and therapies for children with autism spectrum disorders
… of equine-assisted activities and therapies (EAATs) for children with autism spectrum disorders (ASD). Method: This dissertation is composed of two studies. The first study was a systematic mapping review of peer-reviewed literature relevant to EAATs for children with ASD. In conjunction with …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… through excitatory amino acid transporters (EAATs) was faster in astrocytes from PrP knockout (PrP KO) mice than in astrocytes from C57BL/10 SnJ wildtype (WT) mice. Experiments using EAAT subtype-specific inhibitors demonstrated that in both WT and PrP KO astrocytes, the majority of transport …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… through excitatory amino acid transporters (EAATs) was faster in astrocytes from PrP knockout (PrP KO) mice than in astrocytes from C57BL/10 SnJ wildtype (WT) mice. Experiments using EAAT subtype-specific inhibitors demonstrated that in both WT and PrP KO astrocytes, the majority of transport …
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SYNTHESIS OF N<sub>B</sub>-ARYL-ASPARTAMIDES, N<sub>a</sub>-ARYLAMIDE-ASPARTATES, AND HYDROXY-L-PROLINE DERIVATIVES AS INHIBITORS OF AMINO ACID TRANSPORT FOR EVALUATING THE GLUTAMINE / GLUTAMATE CYCLE
… & 2) and the excitatory amino acid transporters EAATs (subtypes 1-3), both involved in the glutamate / glutamine cycle. Furthermore, we have identified a number of potent substrate and nonsubstrate inhibitors of the ASCT and EAAT transporters by electrophysiological and radiolabeled uptake …
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SYNTHESIS OF N<sub>B</sub>-ARYL-ASPARTAMIDES, N<sub>a</sub>-ARYLAMIDE-ASPARTATES, AND HYDROXY-L-PROLINE DERIVATIVES AS INHIBITORS OF AMINO ACID TRANSPORT FOR EVALUATING THE GLUTAMINE / GLUTAMATE CYCLE
… & 2) and the excitatory amino acid transporters EAATs (subtypes 1-3), both involved in the glutamate / glutamine cycle. Furthermore, we have identified a number of potent substrate and nonsubstrate inhibitors of the ASCT and EAAT transporters by electrophysiological and radiolabeled uptake …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… by the excitatory amino-acid transporters (EAATs). In these studies, we investigated the role of EAAT1-3 in synaptic transmission at the Schaffer-CA1 synapse in acute hippocampal brain slices. My results demonstrated that transport block by L-TBA resulted in glutamate spillover and …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… by the excitatory amino-acid transporters (EAATs). In these studies, we investigated the role of EAAT1-3 in synaptic transmission at the Schaffer-CA1 synapse in acute hippocampal brain slices. My results demonstrated that transport block by L-TBA resulted in glutamate spillover and …
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BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP
… a family of excitatory amino acid transporters (EAATs) that rapidly sequester and concentrate glutamate in glia and neurons, and thereby influence transmitter access to EAA receptors. In contrast to the EAAT-mediated uptake of L-Glu, the system Xc- (SXc-) transporter (an obligate exchanger of …
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BIOISOSTERES OF AMPA: CONFORMATIONAL ANALYSIS AND STRUCTURE ACTIVITY RELATIONSHIP
… a family of excitatory amino acid transporters (EAATs) that rapidly sequester and concentrate glutamate in glia and neurons, and thereby influence transmitter access to EAA receptors. In contrast to the EAAT-mediated uptake of L-Glu, the system Xc- (SXc-) transporter (an obligate exchanger of …
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Mass Spectrometric Characterization and Fluorophore-Assisted Light Inactivation of Human Excitatory Amino Acid Transporter
… were found to be able to irreversibly inactivate EAATs under UV-A illumination. The mechanism underlying the photo-inactivation was shown to be singlet oxygen mediated protein oxidation. The specificity of the photo-inactivation was illustrated by the protection effects of inhibitors, as well as …
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Mass Spectrometric Characterization and Fluorophore-Assisted Light Inactivation of Human Excitatory Amino Acid Transporter
… were found to be able to irreversibly inactivate EAATs under UV-A illumination. The mechanism underlying the photo-inactivation was shown to be singlet oxygen mediated protein oxidation. The specificity of the photo-inactivation was illustrated by the protection effects of inhibitors, as well as …
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The role of glutamate transporters and the scaffolding protein IQGAP1 in the regulation of AMPA receptor trafficking and turnover
… excitatory amino acid transporters (EAATs) re-uptake released glutamate, thereby curtailing the strength of AMPAR synaptic activation. Although the coordination of glutamate receptors and transporters likely occurs, whether and how transporter activity affects AMPAR synaptic …