Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"EAAT2"”.
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Mass Spectrometric Characterization and Fluorophore-Assisted Light Inactivation of Human Excitatory Amino Acid Transporter
… excitatory amino acid transporter 2 (EAAT2) mediates the bulk of glutamate re-uptake in the human central nervous system (CNS) and is associated with a variety of neurological disorders. Our understanding of the structure and mechanism of this integral membrane protein is limited. The …
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Mass Spectrometric Characterization and Fluorophore-Assisted Light Inactivation of Human Excitatory Amino Acid Transporter
… excitatory amino acid transporter 2 (EAAT2) mediates the bulk of glutamate re-uptake in the human central nervous system (CNS) and is associated with a variety of neurological disorders. Our understanding of the structure and mechanism of this integral membrane protein is limited. The …
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Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors
… (Ki values of 9 µM for EAAT1, 10.0 µM for EAAT2 and 0.8 µM for EAAT3), acts competitively, and exhibits a 10-fold preference for EAAT3 compared to EAAT1 and EAAT2. Electrophysiological recordings of EAAT-mediated currents in Xenopus oocytes further identified L-β-BA as a non-substrate …
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Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors
… (Ki values of 9 µM for EAAT1, 10.0 µM for EAAT2 and 0.8 µM for EAAT3), acts competitively, and exhibits a 10-fold preference for EAAT3 compared to EAAT1 and EAAT2. Electrophysiological recordings of EAAT-mediated currents in Xenopus oocytes further identified L-β-BA as a non-substrate …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… computationally based pharmacophore models. An EAAT2-specific model was created with four potent and selective ligands that act as non-substrate inhibitors: cis-5-methyl-L-trans-2,3-pyrrolidine dicarboxylate, L-anti-endo-3,4-methano-pyrrolidine-3,4-dicarboxylate (L-anti-endo-3,4-MPDC), …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… computationally based pharmacophore models. An EAAT2-specific model was created with four potent and selective ligands that act as non-substrate inhibitors: cis-5-methyl-L-trans-2,3-pyrrolidine dicarboxylate, L-anti-endo-3,4-methano-pyrrolidine-3,4-dicarboxylate (L-anti-endo-3,4-MPDC), …
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Identifying novel therapeutic targets for seizures and brain cancers
… reduced excitatory amino acid transporter 2 (EAAT2) expression and reduced XCT were associated with greater frequency of TAS. We found that EAAT2 single nucleotide mutations correlated with an increased susceptibility to cerebral palsy in pre-term infants, implicating glutamate excess as the …
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Genomic Discovery of recurrent CD44-SLC1A2 Gene Fusion in Gastric Cancer
… recurrent genomic breakpoints in the SLC1A2/EAAT2 glutamate transporter. 5' RACE analysis of a breakpoint-positive cell line (SNU16) revealed expression of a CD44-SLC1A2 fusion transcript, caused by a paracentric chromosomal inversion, which was predicted to produce a truncated but functional …
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Expression der Glutamattransporter GLT1 und GLAST im Gyrus dentatus der Ratte nach Läsion der Regio entorhinalis
… von Glutamattransportern kloniert: GLT1 oder EAAT2 (Pines et al., 1992), GLAST oder EAAT1 (Storck et al., 1992), EAAC1 oder EAAT3 (Kanai & Hedinger, 1992), EAAT4 (Fairman et al., 1995) und EAAT5 (Arriza et al., 1997). GLT1, GLAST und EAAC1 werden im gesamten ZNS exprimiert (Kanai & Hedinger, …
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Development of a method to assess EAAT1 transcription levels in Alzheimer's disease
… Glutamattransporter und stellt nach EAAT2 den quantitativ wichtigsten Glutamattransporter im ZNS dar. In diesem Projekt wurde eine bis dahin für den Menschen nicht bekannte EAAT1 Spleißvariante, in der Exon 3 ausgeschnitten wird, nachgewiesen. Diese Variante wurde EAAT1Δ3 genannt und …
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Neuroinflammation, Glutamate Regulation and Memory
Neuroinflammation and excessive glutamatergic signaling have deleterious effects in the brain, are mutually promoting, and play a role in the onset and progression of neurodegenerative diseases. It was my goal to better understand the relationship between neuroinflammation, glutamate dysregulation …