Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"EAAT1"”.
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Development of a method to assess EAAT1 transcription levels in Alzheimer's disease
… Der exitatorische Aminosäuretransporter 1 (EAAT1) gehört zu der Familie der Na+-abhängigen Glutamattransporter und stellt nach EAAT2 den quantitativ wichtigsten Glutamattransporter im ZNS dar. In diesem Projekt wurde eine bis dahin für den Menschen nicht bekannte EAAT1 Spleißvariante, in der …
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Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors
… more potent diastereomer (Ki values of 9 µM for EAAT1, 10.0 µM for EAAT2 and 0.8 µM for EAAT3), acts competitively, and exhibits a 10-fold preference for EAAT3 compared to EAAT1 and EAAT2. Electrophysiological recordings of EAAT-mediated currents in Xenopus oocytes further identified L-β-BA …
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Design, Synthesis and Biological Evaluation of a Family of Excitatory Amino Acid Transporter 3 (EAAT3) Preferring Inhibitors
… more potent diastereomer (Ki values of 9 µM for EAAT1, 10.0 µM for EAAT2 and 0.8 µM for EAAT3), acts competitively, and exhibits a 10-fold preference for EAAT3 compared to EAAT1 and EAAT2. Electrophysiological recordings of EAAT-mediated currents in Xenopus oocytes further identified L-β-BA …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… modulatory mechanism that is specific for EAAT1. Thus, a series of sulfated neuroactive steroids, including pregnenolone sulfate (PREGS), were found to selectively increase the ability of EAAT1 to transport atypical substrates like D-aspartate and L-cysteine, but not L-glutamate. The effect …
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Pharmacological Modeling and Regulation of Excitatory Amino Acid Transporters (EAATs)
… modulatory mechanism that is specific for EAAT1. Thus, a series of sulfated neuroactive steroids, including pregnenolone sulfate (PREGS), were found to selectively increase the ability of EAAT1 to transport atypical substrates like D-aspartate and L-cysteine, but not L-glutamate. The effect …
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Investigating the TrkB Interactome during Development and in Neurodegeneration
… excitatory amino acid transporter 1 (EAAT1). BDNF stimulation interrupts the TrkB-EAAT1 interaction and leads to increased EAAT1-dependent glutamate uptake in primary hippocampal cultures, elucidating a novel crosstalk between neurotrophin receptor and glutamate transporter. The …
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Regulatory Balance Between the Peptide Trasporter, Pept1, and Amino Acid Transporter Gene Expression in the Enterocyte
… study. These cells express PepT1, HPT1, PTR3 EAAT1, EAAT3, rBAT, Bo,+AT CAT1, LAT1, y+LAT1, y+LAT2, ABCC3, ABCC4, which increased from D0 to D21 post confluency, indicating cell maturation. In Caco-2 cells, PepT1 gene silencing was induced in Caco-2 cells. Despite an reduction of PepT1 gene …
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Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea
… excitatory amino acid transporter 1 promoter (EAAT1) in conjunction with GFP. Whole mount and paraffin samples from these studies illustrate the effectiveness of AAV in transducing the sensory epithelium of guinea pig cochleae. In particular, the CAG promoter was shown to drive gene expression …
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Adeno-Associated Mediated Transduction of Sensory Epithelia Within the Guinea Pig Cochlea
… excitatory amino acid transporter 1 promoter (EAAT1) in conjunction with GFP. Whole mount and paraffin samples from these studies illustrate the effectiveness of AAV in transducing the sensory epithelium of guinea pig cochleae. In particular, the CAG promoter was shown to drive gene expression …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… the majority of transport was mediated by EAAT1. Furthermore, PrP KO astrocytes were more effective than WT astrocytes at alleviating L-glutamate-mediated excitotoxic damage in both WT and PrP KO neuronal cultures. Thus, in this model, PrP KO astrocytes exerted a functional influence on …
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Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… the majority of transport was mediated by EAAT1. Furthermore, PrP KO astrocytes were more effective than WT astrocytes at alleviating L-glutamate-mediated excitotoxic damage in both WT and PrP KO neuronal cultures. Thus, in this model, PrP KO astrocytes exerted a functional influence on …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… In these studies, we investigated the role of EAAT1-3 in synaptic transmission at the Schaffer-CA1 synapse in acute hippocampal brain slices. My results demonstrated that transport block by L-TBA resulted in glutamate spillover and activation of NMDARs. Further investigation showed that …
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Structure and function of glutamate transporters
… by the excitatory amino acid transporters (EAAT1-5). This research derives from a study of X-ray crystal structures of an homologous archaeal transporter. Broadly, using computational methods to probe EAAT homology models born from the archaeal structures, we introduce/describe novel Na+ and …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… In these studies, we investigated the role of EAAT1-3 in synaptic transmission at the Schaffer-CA1 synapse in acute hippocampal brain slices. My results demonstrated that transport block by L-TBA resulted in glutamate spillover and activation of NMDARs. Further investigation showed that …
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Structure and function of glutamate transporters
… by the excitatory amino acid transporters (EAAT1-5). This research derives from a study of X-ray crystal structures of an homologous archaeal transporter. Broadly, using computational methods to probe EAAT homology models born from the archaeal structures, we introduce/describe novel Na+ and …
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Expression der Glutamattransporter GLT1 und GLAST im Gyrus dentatus der Ratte nach Läsion der Regio entorhinalis
… GLT1 oder EAAT2 (Pines et al., 1992), GLAST oder EAAT1 (Storck et al., 1992), EAAC1 oder EAAT3 (Kanai & Hedinger, 1992), EAAT4 (Fairman et al., 1995) und EAAT5 (Arriza et al., 1997). GLT1, GLAST und EAAC1 werden im gesamten ZNS exprimiert (Kanai & Hedinger, 1992; Pines et al., 1992; Storck et al., …