Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"E6AP"”.
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HPV E6 inhibits E6AP to regulate epithelial homeostasis by modulating keratinocyte differentiation commitment and YAP1 activation
… targets of low-risk and high-risk E6 proteins, E6AP and NHERF1, on the key components of epithelial homeostasis: cell density, proliferation, commitment to differentiation and basal layer delamination. Importantly, we demonstrate that deletion of E6AP in keratinocytes delayed the onset of …
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Affinity Maturation of Peptides to Bind Protein-Protein Interfaces
… 6 (E6), which recruits the E3 ubiquitin ligase E6AP and redirects its activity towards ubiquitinating p53. Targeting the protein interaction interfaces between HPV E6 and E6AP is a promising modality to mitigate HPV-mediated degradation of p53. Herein, we designed a covalent peptide inhibitor, …
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Small Molecule Inhibitors of HPV16 E6
… of E6 to bind in vitro to both caspase 8 and to E6AP, the protein that mediates p53 degradation. In addition, both compounds were able to increase caspase 3/7 activity and to sensitize HPV+ SiHa cells, but not HPV- C33A cells, to apoptosis induced by TRAIL, a cancer-specific ligand, as well as …