Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"E6 protein"”.
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THE ROLE OF E6 PROTEIN IN HUMAN PAPILLOMAVIRUS ASSOCIATED UPPER AIRWAY DISEASES
… a subset of head and neck cancers, respectively. E6 protein is considered one of the oncoproteins encoded by high-risk HPVs, due to its ability to degrade tumor suppressor p53, activate telomerase, avoid apoptosis and other functions that contribute to carcinogenesis. Most of the functions of …
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THE ROLE OF E6 PROTEIN IN HUMAN PAPILLOMAVIRUS ASSOCIATED UPPER AIRWAY DISEASES
… a subset of head and neck cancers, respectively. E6 protein is considered one of the oncoproteins encoded by high-risk HPVs, due to its ability to degrade tumor suppressor p53, activate telomerase, avoid apoptosis and other functions that contribute to carcinogenesis. Most of the functions of …
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Beteiligung der Gene E6 und E7 des Mastomys natalensis Papillomvirus an der Entstehung von Hauttumoren in transgenen Mäusen
… Arbeit untersucht die Beteiligung der E6- und E7-Onkoproteine des kutanen Mastomys natalensis Papillomvirus (MnPV) an der Entstehung von Hauttumoren in transgenen Mäusen. Durch den Einsatz MnPV-E6-transgener Mäuse in eine Mehrstufenkarzinogenese konnte gezeigt werden, daß das kutane …
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Discovering the p53 isoforms’ code
… we hypothesise that the so-called p53 is a multi-protein system composed by the twelve isoforms and that a p53-mediated cell response is, in fact, the sum of the intrinsic activities of the co-expressed p53 isoforms.<br/>Here, we report that the TP53 gene always co-expresses several p53 protein …
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Understanding and Targeting Clearance of Persistent HPV Infections
… of keratinocytes with and without exogenous HPV E6 expression. Two in vitro model systems were developed to mimick the basal/suprabasal layers of the epithelium and evaluate HPV E6 functions in modulating cellular environment based on either the expression of a real-time cell cycle indicator …
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Characterization of the molecular mechanisms underlying retinoic acid induced growth inhibition in MCF-7 human breast cancer cells.
… decreased phosphorylation of the retinoblastoma protein (pRb). It also resulted in a down regulation of cyclin dependent kinase 2 (cdk2) and cyclin D1 gene expression and a profound down regulation of cdk2 activity. In contrast, no changes were seen in cdk4 expression or activity. We have further …