Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 179 for “"E3 ubiquitin ligase"”.
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바이러스 감염시 미토콘드리아 E3 ubiquitin ligase 인 MARCH5의 새로운 생체 기능
… central role in preserving cellular homeostasis. Ubiquitin proteasome system (UPS) on the mitochondria is one of quality control systems that works as a first line barrier against aggregated or misfolded proteins. In this study, I investigated functional role of mitochondrial E3 ligase, MARCH5, …
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Functional Interactions Between Par-1b Protein Kinase and RNF41 E3 Ubiquitin Ligase
… associated proteins. Nrdp1/RNF41, a RING finger E3 ligase was identified in their screen along with 14-3-3 and aPKC. I found that Par-1b binds to RNF41 and I identified RNF41 as a novel cell polarity determinant. My work demonstrated that phosphorylation of RNF41 on S254 by Par-1b is necessary …
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Biochemical Characterization of IpaH E3 Ubiquitin Ligase Effector Proteins and Their Host Substrates
… including Salmonella and Yersinia secreted E3 ubiquitin ligases into the host cell cytoplasm via the Type III secretion system (T3SS) apparatus. The invasion plasmid antigen Hs (IpaHs) are a novel family of bacterial E3 ubiquitin ligases that are secreted by Shigella, Salmonella, and …
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Defining a Novel Role for the E3 Ubiquitin Ligase Wwp1 in Cardiac Arrhythmogenesis
… lab is interested in examining the role of the ubiquitin ligase Wwp1 in regulating Cx expression during normal postnatal cardiac development as well as in gap junction remodeling associated with cardiac dysfunction. Thus, we created a mouse model which completely lacks Wwp1 activity (Wwp1-/-) as …
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Developing Constrained p27 Peptides to Target the Oncogenic E3 Ubiquitin Ligase SCF-Skp2
The ubiquitin-proteasome system (UPS) maintains homeostatic levels of proteins in normal cells and controls the levels of oncogenes and tumour suppressors by tagging proteins with ubiquitin for proteasomal degradation. The UPS is regulated by sequential action of three enzymes: E1 – ubiquitin …
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Investigation of the E3 ubiquitin ligase UBR5; a novel regulator of Hh gene expression
The Hedgehog (Hh) signalling pathway is essential for embryogenesis and regulating cellular homeostasis in the adult, however much remains unknown about the molecular mechanisms that control ligand expression. In 2002, Lee et al. demonstrated that conditional mutation of the Drosophila hyperplastic …
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The role of E3 ubiquitin ligase CBLB in mediating innate immunity to pulmonary infections
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Regulation of microRNA degradation in Caenorhabditis elegans via the E3 ubiquitin ligase EBAX-1
… shift in AGO, leading to the recruitment of an E3 ubiquitin ligase complex containing the substrate receptor ZSWIM8. The subsequent polyubiquitination and proteolysis of AGO liberates the miRNA, rendering it vulnerable to nucleases. TDMD underlies the instability of many miRNAs in diverse cell …
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Characterizing the Role of the E3 Ubiquitin Ligase Subunit MAEA in DNA Repair and Replication
… for the first time the role of the CTLH E3 ubiquitin ligase complex catalytic subunit MAEA in the DNA damage response. I identified MAEA through focused CRISPR- Cas9 screens using the chemotherapeutic agents camptothecin and etoposide. My subsequent investigations demonstrate that MAEA …
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Cop 9 Signalosome Subunit 6 Stabilizes Cop1, A Novel E3 Ubiquitin Ligase For 14-3-3Σ
… Photomorphogenic 1 (COP1) as a novel E3 ubiquitin ligase for targeting 14-3-3σ through proteasome degradation. We show for the first time that COP9 signalosome subunit 6 (CSN6) associates with COP1 and is involved in 14-3-3σ ubiquitin-mediated degradation. Mechanistic studies show that …
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A Genetic Screen for Tribbles Suppressors Identifies the E3 Ubiquitin Ligase Neuralized as a Novel Target
… targets and from our screen we identified three E3 Ubiquitin ligases as novel interactors; Neuralized, Mindbomb1 and Parkin. Of the targets identified from the screen, we focused on Neuralized. We found that Tribbles physically bound to Neuralized in a yeast two hybrid assay and in vivo, Tribbles …
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Regulation Of Acute Myeloid Leukemia Cell Proliferation By E3 Ubiquitin Ligase DCAF15 Control Of Cohesin Dynamics
The CRL4-DCAF15 E3 ubiquitin ligase complex is targeted by the aryl-sulfonamide molecular glues, leading to neo-substrate recruitment, ubiquitination, and proteasomal degradation. However, the physiological function of DCAF15 remains unknown. Using a domain-focused genetic screening approach, we …
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Protein-Protein Interactions and Small Molecule Targeting of the Multisubunit SOCS2-EloBC-Cul5-Rbx2 E3 Ubiquitin Ligase
The Cullin-RING E3 ligases (CRLs) are the largest subfamily of E3 ligases that participate in many biological processes determining the fate of proteins by catalysing ubiquitin transfer to specific substrates for proteasomal degradation. SOCS2 is a component of the multisubunit CRL E3 complex …
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E3 Ubiquitin Ligase Cbl-b deficient T cells resist Treg cell-mediated suppression and enhance anti-tumor immunity
… Here, we specifically investigated the role of E3 ubiquitin ligase Cbl-b in establishing T cell resistance to Treg cell-mediated suppression. First, we found that the absence of Cbl-b, a negative regulator of multiple TCR signaling pathways, rendered CD8+ T cells impartial to Treg cell-mediated …
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Targeting an E3 ubiquitin ligase Siah1 and a cysteine protease SENP1 using SPR and DSF-based fragment screening
… modification pathways. Siah1 is an E3 ubiquitin ligase that functions as a scaffold to transfer ubiquitin bound to an E2 ubiquitin-conjugating enzyme to a substrate as part of the ubiquitination pathway. SENP1 is a cysteine protease that catalyses two essential reactions in the SUMO …
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Role of the ubiquitin-proteasome pathway in the inner ear : identification of an E3 ubiquitin ligase for Atoh1
… the amount of protein be decreased. Since the ubiquitin-proteasome pathway regulates catabolism of key regulatory proteins, we assessed its role in the degradation of Atoh1. E3 ubiquitin ligases confer substrate specificity to degradation of proteins by transferring a ubiquitin tag to a …
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Discovery of a novel meiotic E3 ubiquitin ligase by characterisation of the barley desynaptic mutant <i>DES12.W</i>
… STicky Telomere Polycomplex 1 (STTP1). In-vitro ubiquitination assays and phylogenetic analyses revealed that STTP1 is a cereal-specific E3 ubiquitin ligase. Cytological analysis indicated that loss of STTP1 causes a loss of recombination, but a detailed recombination assay exposed that there is, …
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