Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"E3 ligase itch"”.
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Roles for the E3 Ligase Itch in Immune Response Modulation
… in the agouti mutant strain a has implicated the E3 ligase Itch in the spontaneous inflammation that occurs in these mice. 1 RH Anaylsis of a mice suggests that the inflammatory disease is due to a dysregulated T helper type-2 immune response. In order to verify the importance of Itch inactivation …
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The Role of NDFIP1 in T Cell Tolerance
… T cell tolerance. Ndfip1 is an adaptor for E3 ubiquitin ligases of the Nedd4 family. In Th2 cells, Ndfip1 is necessary for the degradation of JunB by the Nedd4 family E3 ligase Itch. Consequently, Ndfip1 limits IL-4 expression in Th2 cells. Here we present evidence that Ndfip1 also limits …
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A study of the causes and consequences of SFTPC mistrafficking in alveolar type 2 cells using novel organoid models
… forward genetic screens, I identified the E3 ligase ITCH as a novel effector of SFTPC processing, and confirmed its importance in SFTPC maturation by developing a genetically manipulable alveolar organoid model in which to test the consequence of ITCH depletion. Using this novel organoid …